unresectable malignant melanoma. Principal investigator (W. Samlowski) 9/1/2011-12/31/2012. Patents Fowers KD, Zentner GM, Baudys M, Jurek M, Samlowski W: Formulations of lymphokines and method of use thereof for local or both local and systemic control of proliferative cell disorders (US Patent US2006/0159657, Europe 2739877.5-2108) Samlowski WE, Adams NB, McGregor JR: Gene therapy of cancer using an IL-2 transmembrane construct (US 7,407,777, World 2004/080404). Samlowski WE, Kondapaneni M, McGregor JR. Methods and compounds for the inhibition of eNOS activity. (US 5/23/06 US2007012410 Europe 5/23/07 077952298.4-1216) Published works Natl. Cooperative Oncology Group Clinical Trial Authorship Evaluation of biologic markers that may predict sensitivity or resistance of recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) to phase II chemotherapy agents: Pathology ancillary study (SWOG 9807). Primary study coordinator. Evaluation of the combination of docetaxel/carboplatin in patients with metastatic or recurrent squamous cell carcinoma of the head and neck (SCCHN)(SWOG 9902). Primary study coordinator. Evaluation of 3-hour infusion of paclitaxel plus cisplatin and 5-fluorouracil in patients with advanced/recurrent squamous cell carcinoma of the head and neck (SCCHN): Phase II (S0007). Co-investigator. A Phase II trial of imatinib mesylate (Gleevec) in neuroendocrine carcinoma of the skin (Merkel Cell Carcinoma) (S0331). Primary study coordinator. Peer-reviewed publications Samlowski WE, Kondapaneni M, McGregor JR, Tharkar, S, Laubach VE, Salvemini D. Endothelial nitric oxide synthase (eNOS) is a key mediator of interleukin-2 (IL-2) induced hypotension and vascular leak syndrome. J Immunother 34:419-27, 2011. Eroglu Z, Kong M, Jakowatz JG, Akerly W, Samlowski W, Fruehauf JP. Phase II clinical trial evaluating docetaxel, vinorelbine and GM-CSF in stage IV melanoma. (in press, Cancer Chemother Pharmacol). Donepudi S, DeConti R, Samlowski WE. Recent advances in understanding the genetics etiology and treatment of Merkel cell carcinoma. (in press, Seminars in Oncology). Samlowski EE, Dechet C, Weissman A, Samlowski WE. Large cell non-Hodgkin’s lymphoma masquerading as renal carcinoma with IVC thrombosis: A case report. (in press, Journal of Medical Case Reports). Book chapters, reviews, editorials and letters to editor Eroglu Z, Kong M, Jakowatz JG, Akerly W, Samlowski W, Fruehauf JP. “Phase II clinical trial evaluating docetaxel, vinorelbine and GM-CSF in stage IV melanoma.” Cancer Chemother Pharmacol 68:1081-1087, 2011 Wong B, Samlowski WE. Renal Cancer. In "Medical Therapy in Urology", Springer-Verlag, 2010. pp 17–31 Samlowski WE, Becker J. The Potential for Targeted Therapy of Merkel Cell Carcinoma. In Merkel Cell Carcinoma: A Multidisciplinary Approach by Sondak VK, Messina JL, Zager