Series for Arden International and was the team's first woman driver in history. She had tested a World Series Formula V8 3.5 car with Pons Racing at Ciudad del Motor de Aragón in November 2015 before choosing GP3 two months later because it was faster. Calderón scored two points from tenth-place finishes at the Hockenheimring and the Autodromo Nazionale Monza for 21st in the drivers' championship. She was slow in qualifying, giving her an average starting position of 17th. Calderón was third at the Red Bull Ring and took 66 points for Teo Martín Motorsport and then RP Motorsport in six rounds of the Euroformula Open Championship. She was also a panellist on the Canal F1 Latin America show Directo Fórmula. At the end of 2016, Calderón was introduced to the Sauber Formula One team principal Monisha Kaltenborn and began working for Sauber as a development driver. In addition to continuing her GP3 schedule, she conducted tests in Sauber's simulator and joined the team at race weekends. Calderón switched teams from Arden to DAMS for the 2017 season. She had a best result of seventh at the Monza feature race and was eighth at the Circuto de Jerez to finish 18th in the drivers' championship with seven points. Calderón drove in the series-ending round of the World Series Formula V8 3.5 at Bahrain International Circuit in place of Damiano Fioravanti at RP Motorsport. She finished third in the second race, taking the first podium finish for a woman in the series. She moved to Jenzer Motorsport for the 2018 GP3 Series after DAMS left the championship. A month later, Sauber made Calderón its test driver, spending time in the team's simulator and engineers coached her at its headquarters and race circuits. In GP3, her performance improved from 2017, scoring 11 points over seven races for a championship placing of 16th. After Calderón expressed her hope of testing for Sauber before the year was over, she drove the team's C37 in a promotional day at the Autódromo Hermanos Rodríguez on 30 October, becoming the first Latin American woman to drive a Formula One car. Calderón drove a 2013 C32 car in a two-day test session at the Fiorano Circuit a month later. On 16 December, she tested the Techeetah DS E-TENSE FE19 electric car at the inaugural Formula E in-season test in Ad Diriyah, and drove it again in the series'