20% reduction in PN volume on MRI that was confirmed on a subsequent MRI within 3 to 6 months. The ORR was 66% and all subjects had a partial response, meaning that no subjects had complete disappearance of the tumor. Of these subjects, 82% had a response lasting 12 months or longer. The trial was conducted at four sites in the United States. Other clinical outcomes for subjects during selumetinib treatment included changes in PN-related disfigurement, symptoms and functional impairments. Although the sample sizes of subjects assessed for each PN-related morbidity (such as disfigurement, pain, strength and mobility problems, airway compression, visual impairment and bladder or bowel dysfunction) were small, there appeared to be a trend of improvement in PN-related symptoms or functional deficits during treatment. Research Selumetinib has also been shown to inhibit growth of GNAQ mutated uveal melanoma cell lines. Furthermore, preliminary results suggest that selumetinib treatment of uveal melanoma patients can result in tumor shrinkage as the consequence of sustained inhibition of ERK phosphorylation. A Phase II clinical trial about selumetinib in NSCLC was completed in September 2011; one about cancers with BRAF mutations is ongoing . In July 2015, selumetinib failed a Phase III trial testing whether the drug significantly prolonged the survival of patients in a study on melanoma originating in the eye. In the 152-patient trial, a combination of selumetinib and dacarbazine failed to improve progression-free survival compared with just the old drug alone. , there were other phase III trials registered for thyroid cancer, and KRAS positive NSCLC. The combination of selumetinib to chemotherapy improved median progression-free survival in a trial of 510 patients with advanced KRAS-mutant NSCLC just for one month, which was statistically not significant. In November 2018, investigators working with nasal polyp tissue in vitro demonstrated a synergistic effect of down regulating expression of p-MEK1 and p-ERK1 when it was administered with erythromycin. References Further reading External links Antineoplastic drugs AstraZeneca brands Breakthrough therapy Bromoarenes Carboxylate esters Chlorobenzenes Fluoroarenes MEK inhibitors Orphan drugs Primary alcohols