69–55 | Ramone Moore – 15 | Eric – 15 | Fernandez – 6 | José Miguel Agrelot Coliseum, San Juan, PR | 2–0 |- align="center" bgcolor="#FFE6E6" | 3 | November 18 | Purdue | L 85–77 | Moore – 27 | Eric – 8 | Moore/Rahlir Hollis-Jefferson/T.J. DiLeo – 3 | José Miguel Agrelot Coliseum, San Juan, PR | 2–1 |- align="center" bgcolor="#D8FFEB" | 4 | November 20 | Wichita State | W 78–74 (OT) | Moore – 23 | Eric – 12 | Khalif Wyatt – 4 | José Miguel Agrelot Coliseum, San Juan, PR | 3–1 |- align="center" bgcolor="#FFE6E6" | 5 | November 27 | Bowling Green | L 67–64 | Wyatt – 19 | Anthony Lee – 9 | Wyatt/Moore – 4 | Stroh Center, Bowling Green, OH | 3–2 |- |- align="center" bgcolor="#D8FFEB" | 6 | December 3 | Central Michigan | W 86–74 | Wyatt – 23 | Moore – 8 | Wyatt – 9 | Liacouras Center, Philadelphia, PA | 4–2 |- align="center" bgcolor="#D8FFEB" | 7 | December 7 | Toledo | W 77–58 | Aaron Brown – 19 | Lee – 9 | Moore – 7 | Savage Arena, Toledo, OH | 5–2 |- align="center" bgcolor="#D8FFEB" | 8 | December 10 | Villanova | W 78–67 | Moore – 32 | Hollis-Jefferson – 14 | Fernandez – 4 | Liacouras Center, Philadelphia, PA | 6–2 |- align="center" bgcolor="#FFE6E6" | 9 | December 17 | Texas | L 65–77 | | | | Frank Erwin Center, Austin, TX | 6–3 |- align="center" bgcolor="#D8FFEB" | 10 | December 19 | Rice | W 77–70 | | | | Tudor Fieldhouse, Houston, TX | 7–3 |- align="center" bgcolor="#D8FFEB" | 11 | December 28 | Buffalo | W 87–85 | | | | Liacouras Center, Philadelphia, PA | 8–3 |- align="center" bgcolor="#D8FFEB" | 12 | December 30 | Delaware | W 66–63 | | | | Bob Carpenter Center, Newark, DE | 9–3 |- align="center" bgcolor="#D8FFEB" | 13 | January 4 | Duke | W 78–73 | | | | Wells Fargo Center, Philadelphia, PA | 10–3 |- align="center" bgcolor="#D8FFEB" | 14 | January 7 | Dayton | L 77-87 | | | | Liacouras Center, Philadelphia, PA | 10-4(0-1) |- align="center" bgcolor="#D8FFEB" | 15 | January 11 | Saint Louis | W 72-67 | | | | Chaifetz Arena, St. Louis, MO | 11-4(1-1) |-