Dynein axonemal light chain 1, (LC1) is a protein that in humans is encoded by the DNAL1 gene. Function LC1 is a component of outer dynein arms, which contain the molecular motors for ATP-dependent cilia movement. Clinical significance Mutations in the DNAL1 gene are associated with primary ciliary dyskinesia. References External links GeneReviews/NCBI/NIH/UW entry on Primary Ciliary Dyskinesia