Lyme Center is an unincorporated community in the town of Lyme in Grafton County, New Hampshire, in the United States. It is located close to the geographic center of the town of Lyme, approximately east of New Hampshire Route 10 where it passes through the main village of Lyme. The center of the village is listed on the National Register of Historic Places as the Lyme Center Historic District. Lyme Center has a separate ZIP code (03769) from the rest of the town of Lyme. References Unincorporated communities in New Hampshire Unincorporated communities in Grafton County, New Hampshire Lyme, New Hampshire