February 19, 2022, Thompson signed with the Chicago Bulls. Career statistics NBA Regular season |- | style="text-align:left;"| | style="text-align:left;"|Cleveland | 60 || 25 || 23.7 || .439 || .000 || .552 || 6.5 || .5 || .5 || 1.0 || 8.2 |- | style="text-align:left;"| | style="text-align:left;"|Cleveland | style="background:#cfecec;"| 82* || 82 || 31.3 || .488 || .000 || .608 || 9.4 || 1.3 || .7 || .9 || 11.7 |- | style="text-align:left;"| | style="text-align:left;"|Cleveland | 82 || 82 || 31.6 || .477 || .000 || .693 || 9.2 || .9 || .5 || .4 || 11.7 |- | style="text-align:left;"| | style="text-align:left;"|Cleveland | 82 || 15 || 26.8 || .547 || || .641 || 8.0 || .5 || .4 || .7 || 8.5 |- | style="text-align:left; background:#afe6ba;"|† | style="text-align:left;"|Cleveland | style="background:#cfecec;"| 82* || 34 || 27.7 || .588 || || .616 || 9.0 || .8 || .5 || .6 || 7.9 |- | style="text-align:left;"| | style="text-align:left;"|Cleveland | 78 || 78 || 29.9 || .600 || .000 || .498 || 9.2 || 1.0 || .5 || 1.1 || 8.1 |- | style="text-align:left;"| | style="text-align:left;"|Cleveland | 53 || 22 || 20.2 || .562 || || .544 || 6.6 || .6 || .3 || .3 ||5.8 |- | style="text-align:left;"| | style="text-align:left;"|Cleveland | 43 || 40 || 27.9 || .529 || || .642 || 10.2 || 2.0 || .7 || .4 || 10.9 |- | style="text-align:left;"| | style="text-align:left;"|Cleveland | 57 || 51 || 30.2 || .512 || .391 || .615 || 10.1 || 2.1 || .6 || .9 || 12.0 |- | style="text-align:left;"| | style="text-align:left;"|Boston | 54 || 43 || 23.8 || .518 || .000 || .592 || 8.1 || 1.2 || .4 || .6 || 7.6 |- | style="text-align:left;" rowspan=3| | style="text-align:left;"|Sacramento | 30 || 3 || 15.2 || .503 || 1.000 || .533 || 5.4 || .6 || .4 || .4 || 6.2 |- | style="text-align:left;"|Indiana | 4 || 0 || 16.4 || .542 || || .375 || 4.5 || .5 || .0 || .5 || 7.3 |- | style="text-align:left;"|Chicago | 23 || 3 || 16.3 || .565 || .000 || .542 || 4.7 || .6 || .5 || .3 || 5.7 |- class="sortbottom" | style="text-align:center;" colspan="2"|Career | 730 || 478 || 26.8 || .519 || .263 || .605 || 8.4 || 1.0 || .5 || .7 || 9.0 Playoffs |- | style="text-align:left;"|2015 | style="text-align:left;"|Cleveland | 20 || 15 || 36.4 || .558