Leucine-rich repeat-containing protein 50 is a protein that in humans is encoded by the LRRC50 gene. Function Leucine-rich repeat-containing protein 50 is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Clinical significance Mutations in the LRRC50 gene are associated with primary ciliary dyskinesia. References Further reading External links GeneReviews/NCBI/NIH/UW entry on Primary Ciliary Dyskinesia