time the Patriots lost at home with Tom Brady as their quarterback in 31 regular season starts, and it was also the first Patriots loss at home where they had a 4th quarter lead in the Tom Brady era. Week 10: at San Francisco 49ers The Giants' winning streak came to an end in San Francisco but they once again had the game in doubt into the final minutes. Field goals comprised the first half scoring, with Lawrence Tynes hitting two and the 49ers' David Akers recording three. The Giants took their only lead in the third quarter as Eli Manning found Mario Manningham for 13 yards to complete an 84-yard drive. The 49ers recorded two touchdowns on a pass to Vernon Davis and a run by Kendall Hunter, while Manning hit Hakeem Nicks for a 32-yard touchdown late in the game. New York received the ball late in the game and drove inside the 49ers' red zone, but Manning's last pass was deflected at the line of scrimmage to preserve the San Francisco win. Manning threw for 311 yards and two touchdowns but also recorded two interceptions, while Alex Smith threw for 242 and the touchdown pass to Davis. Brandon Jacobs rushed for 55 yards to lead the runners while Victor Cruz's 84 yards was tops for the receivers. Week 11: vs. Philadelphia Eagles Playing on Sunday night for the first time all season, the Giants could not take advantage of three Vince Young interceptions and fumbled on their final drive, allowing the Eagles to salvage a split in the season series. New York fell behind 10–0 on an Alex Henery field goal and a touchdown pass from Young to former Giant Steve Smith. Trailing 10–3 entering the fourth, Eli Manning sought out Victor Cruz who caught a pass for 24 yards and the tying touchdown. However, they allowed Young to put together an 18-play drive finishing with a Riley Cooper touchdown pass. The Giants got the ball and Manning completed a pass to Cruz for 47 yards. The next play, Manning was stripped of the ball, sealing the Eagles victory. Despite his three interceptions Young threw for 258 yards in his relief effort for the injured Michael Vick. Manning threw for 264 yards, 128 of which went to Cruz. LeSean McCoy again rushed for 100 yards, recording 113 on 23 carries. Week 12: at New Orleans Saints The