techniques to map the effects of AD on brain connectivity Use of Systems biology approaches to understand AD genetics and its relationship to AD biology Use of high-powered MRI to detect very early structural brain changes associated with AD in patients with no symptoms. Development of models to select participants for AD clinical trials using Precision medicine approaches Other studies modeled on ADNI ADNI's organization, funding structures, standardized methodologies, and open datasharing approaches have been used in a number of different studies. Alzheimer's disease related Worldwide ADNI : documents disease progression in a diverse range of racial and ethnic groups in Europe, Japan, Argentina, South Korea, Australia, China, Italy, and Taiwan with the aim of improving AD clinical trials. Department of Defense ADNI: enrolls Vietnam War veterans to examine the link between traumatic brain injury, posttraumatic stress disorder and AD. Funded by the US Department of Defense ADNI Depression study: examines the link between late life depression and cognitive impairment. Other diseases Parkinson's Progressive Markers Initiative: aims to identify biomarkers for Parkinson's disease progression and to improve clinical trials for Parkinson's disease therapies. North American Registry for Care and Research in Multiple Sclerosis: aims to track disease progression in Multiple sclerosis, identify new biomarkers, openly share data, and to ultimately improve clinical trials for Multiple sclerosis therapies. Down Syndrome Biomarker Initiative: examines link between Down syndrome and AD. References Alzheimer's disease Biological techniques and tools Neuroimaging Biological databases