Phosphatidylinositol 3-kinase-related kinases (PIKKs) are a family of Ser/Thr-protein kinases with sequence similarity to phosphatidylinositol-3 kinases (PI3Ks). Members The human PIKK family includes six members: Structure PIKKs proteins contain the following four domains: N-terminus FRAP-ATM- TRRAP (FAT) domain, kinase domain (KD; PI3_PI4_kinase), PIKK- regulatory domain (PRD), and C-terminus FAT-C-terminal (FATC) domain References External links Kinase Family PIKK at WikiKinome. EC 2.7.11 Protein families