Madhusudhana Rao to direct the film. Doondi signed writer Mullapudi Venkata Ramana to work on the script. His decision was met with severe criticism, as Ramana was known for his humorous works. Ramana took it as a challenge and completed working on the film's script and shot division in a span of two weeks. To tone down the melodrama in the original, Ramana introduced two characters from his fiction works: Apparao, the chronic debtor and his love interest Sita. Both were the subject of Ramana's friend, collaborator and filmmaker Bapu paintings. Cast and crew Savitri was cast as the female lead, reprising her role from Pasamalar. Nahata approached Akkineni Nageswara Rao to play the male lead, but Nageswara Rao politely rejected the proposal, saying that the audience would not accept him playing Savitri's brother, given their reputation as an on-screen romantic pair. Doondi approached N. T. Rama Rao for the same, who accepted the proposal. Kanta Rao was signed as the other male lead, played by Gemini Ganesan in the original. Devika, M. Prabhakar Reddy and Suryakantham were cast in key supporting roles. Relangi and Girija were chosen to play Apparao and Sita respectively, and Ramana Reddy was cast as the latter's father. K. V. S. Sarma and Y. V. Raju played minor roles as the factory owner and servant Subbanna respectively. Nahata and Doondi were impressed with Viswanathan–Ramamoorthy soundtrack and score for the original, and approached them to work on the remake. They expressed their inability due to scheduling conflicts, and instead suggested Ghantasala name. Doondi signed Ghantasala as the film's music composer. C. Nageswara Rao served as the director of photography, and N. S. Prakasham edited the film. Krishna Rao was the film's art director. Filming Rakta Sambandham was majorly filmed in sets erected at Golden Film Studios and Vijaya Vauhini Studios, where the post-production activities were carried out. Doondi and Nahata wanted to wrap the film within a restricted budget. According to Madhusudhan Rao, Rakta Sambandham was physically and mentally demanding for Savitri, though she played the same role in the original. Savitri avoided using glycerol during emotional scenes and preferred method acting. As a result, she had swollen eyes and fainted on sets often. Shooting was cancelled at times due to Savitri's illness. Suryakantham, who played the role of an abusive mother-in-law, could not bear watching Savitri struggle and used to forget her lines. She expressed