walks in to announce his unexpected marriage with Dr. Callie Torres (Sara Ramirez). A cancerous patient, Marina Wagner (Amanda Collins), is admitted into the hospital and is revealed to have toxic blood - which the characters speculate may be caused by a chemical reaction between an herbal supplement and chemotherapy - making several physicians fall ill. O'Malley is exposed to the neurotoxin, and quickly becomes anxious, fearing that his marriage is the cause of the sickness. This bizarre storyline is based in the real-life case of Gloria Ramirez in California in 1994, in which the "herbal supplement" was in fact the solvent dimethyl sulfoxide. Ellis is diagnosed with a heart condition, in which surgery or medication are options. Ellis does not want the surgery, but Meredith fears that she will not be compliant with her medication. Shepherd and Burke try to close up Wagner as the OR was evacuated before her surgery was completed, by entering the operating room with sealed, airtight suits. Ellis agrees to the surgery, but opts to speak with Webber, her former lover. A teenage patient is brought into the clinic by her father, hoping that a doctor can teach her how to use tampons. When her father leaves the room, she explains to Bailey that she had sex, but her pregnancy test is negative. Shepherd and Burke run out of air whilst operating on Wagner, so Yang, Stevens, and Meredith enter holding their breath to close the patient's incision. O'Malley's colleagues act in a rude manner to his new marriage, and displeased, he lectures them, standing up for Torres. Sloan is seen to be having sex with Montgomery, and Yang agrees to marry Burke. At the conclusion of the episode, Ellis' lucidity has vanished, leaving Meredith and Webber distraught. Production The episode was written by co-executive producer Tony Phelan and Joan Rater, while filmmaker Julie Anne Robinson directed it. Featured music includes Psapp's "King of You", The Whitest Boy Alive's "Fireworks", Iain Archer's "Canal Song", Miho Hatori's "Barracuda" and Sybarite's "Runaway". Rater described that she got the idea after being told that her husband had to undergo a craniotomy. She noted that the plan for the episode was to focus on Ellis' inner feelings, mainly her fright, frustration and stress. "The concept of someone with this disease having a lucid day is real. The disease varies for everyone, but experts we talked to said that