relative with a birth defect, inherited disease, or early onset of cancer Pregnant women aged 35 and over on due date, or with an abnormal screening result. Adult and Pediatric General Genetics services are available at the Main Campus. Cancer Genetics services are available at Main Campus (Genomic Medicine Institute and Breast Center), Cleveland Clinic Beachwood Family Health and Surgery Center, Cleveland Clinic Independence Cancer Center, Digestive Disease Institute and Colorectal Surgery (DDI/CORS) and Fairview Hospital’s Moll Pavilion. Preconception/Prenatal Genetic Counseling services are available at Main Campus, Beachwood Family Health Center, Cleveland Clinic Independence Family Health Center and Hillcrest Hospital. Cardiovascular Genetic services are available at Main Campus. CPGH specialists are internationally known for their expertise in : various inherited cancer syndromes, particularly breast, thyroid, endocrine, gastrointestinal, urologic cancers, and Cowden syndrome adult-onset genetic disorders inherited cardiovascular pulmonary diseases Albright hereditary osteodystrophy and pseudohypoparathyroidism heart defects neuromuscular disorders autism metabolic disorders Research Research at the Genomic Medicine Institute is focused on translational genomic medicine. Patient-oriented research protocols include studies on patients with: Patients with a definite or possible diagnosis of Cowden syndrome, Bannayan–Riley–Ruvalcaba syndrome, or other conditions involving a PTEN gene mutation Endocrine tumors such as pheochromocytoma and paragangliomas Unexplained hamartomatous and/or hyperplastic gastrointestinal polyps Chromosomal deletions, specifically the chr 2q37 deletion (brachydactyly-mental retardation syndrome) Familial Barrett esophagus, in association with esophageal cancer. Primary pulmonary hypertension Common disorders related to variation in non-coding genomic sequences Metabolic disease such as diabetes and obesity Clotting and bleeding disorders Genetically controlled absorption of plant sterols for cholesterol Biorepository The Genomic Medicine Biorepository is a sample processing and banking facility that stores patient samples as well as derived products, such as DNA, RNA, protein and cell lines. These samples provide a foundation for all research in genomic medicine at the Cleveland Clinic. The biorepository has received, cataloged, processed, and banked, in excess of 40,000 specimens. These samples are received from both regional and international sources. The biorepository has managed samples that have resulted in more than 150 original peer reviewed articles and greater than $25 million total direct costs in extramural funding from 2005 to 2009. Bioinformatics Core The Bioinformatics Core of the Lerner Research Institute is hosted at the Genomic Medicine Institute, and provides essential analysis for the integration of complex biological and clinical data to researchers across Lerner Research Institute, Cleveland Clinic (and beyond) either as fee-for-service or as collaborative efforts through