Pagnini is an Italian surname. Notable people with the surname include: Eugenio Pagnini (1905–1993), Italian modern pentathlete Giovanni Pagnini (d. 18th century), Italian mathematician Luca Antonio Pagnini (1737 - 1814), Italian translator of Greco-Roman classics Marta Pagnini (born 1991), Italian rhythmic gymnast Santi Pagnini or Santes Pagnino (1470–1541), Italian philologist and Biblical scholar Italian-language surnames