Naled (Dibrom) is an organophosphate insecticide. Its chemical name is dimethyl 1,2-dibromo-2,2-dichloroethylphosphate. Naled is stable in anhydrous condition and must be stored away from light. It must also be stored under normal pressure and temperatures. It degrades in the presence of water and alkali, and produces toxic chloride fumes if exposed to acids or acidic fumes. Contact with metals, reducing agents, or sulfhydryls cause naled to release bromide and revert to dichlorvos. Uses Naled is used primarily to control adult mosquitos. It is also registered to control black flies, and leaf eating insects on a variety of fruits, vegetables, and nuts. Approximately 70% of naled in USA is used in mosquito control, and approximately 30% in agriculture. Naled has also been used in veterinary medicine to kill parasitic worms in dogs. It has been used extensively within the United States since the 1950s. Naled was used in New Orleans after Hurricane Katrina, in North Carolina after Hurricane Florence (2018), and has been used historically in Puerto Rico to control dengue. Toxicity The Environmental Protection Agency has determined that exposure levels from eating crops treated with Naled are below the level of concern. With higher exposures, however, naled can cause cholinesterase inhibition in humans, which in turn can overstimulate the nervous system causing nausea, dizziness, confusion, and at very high exposures, respiratory paralysis and death. It has the UN hazard classification of 6.1 (inhalation hazard) and is prohibited for use as an insecticide within the EU. Naled may cross the placenta if it is in the bloodstream of a mammal. Repeated exposures may also cause future behavioral problems, as well as issues with neurodevelopment, growth, and respiratory health in offspring. Chronic exposure to dichlorvos, a metabolite of naled, has also been linked to neurological issues, such as Parkinson's disease and nigrostriatal dopaminergic degeneration. Persons who work closely with naled or other organophosphate pesticides should undergo regular testing of their cholinesterase levels. EPA classifies naled as Group E or non-carcinogenic for humans. Neither naled nor its metabolite, dichlorvos, build up in breast milk or breast tissue. In a 2017 general-population study of the chemical, University of Michigan researchers found that children in China who had the highest prenatal exposure to naled had, at age 9 months, 3% to 4% lower scores on tests of their fine motor skills, compared with those with the lowest exposure. Ecological effects Naled is considered highly toxic