19, Florimón was placed on the Orioles 40-man roster after his contract was purchased from Bowie. He was re-signed by the Orioles on March 9. Florimón spent spring training with the Orioles until March 26, when he was assigned to Double-A Bowie. Florimón started the 2010 season with Bowie. On May 26, he was placed on the seven-day disabled list. He made his major league debut with the Orioles on September 10. Minnesota Twins On December 5, 2011, he was claimed off waivers by the Minnesota Twins. In 2012, Florimón played in 43 games for the Twins, amassing 137 at bats. He hit .219 with one home run and 10 RBIs. The next season, Florimón competed for the starting shortstop position, which he won by default. In 2012, in 137 at bats he batted .219/.272/.307. Florimón opened the 2013 season as the starting shortstop for the Twins. Despite his strong defensive play at shortstop, Florimón struggled mightily at the plate. In 443 at bats, he hit .221 with 9 home runs, stole 15 bases in 21 attempts, and walked 33 times while striking out 115 times. For the 2014 season, Florimón was anointed the starting shortstop once again, but lasted just 33 games before being demoted the Rochester Red Wings of the Class AAA International League. During his brief stint at the beginning of the season, Florimón hit under the Mendoza line (.092) as he collected just 7 hits in his 76 at bats for Minnesota. He finished the season with Rochester without receiving a September call-up. Pittsburgh Pirates On September 18, 2014, the Washington Nationals claimed Florimón from the Twins off of waivers. On November 20, the Pittsburgh Pirates claimed Florimón from the Nationals off of waivers. He was designated for assignment on April 5, 2015. On April 11, he was outrighted to the Indianapolis Indians. On July 22, he was called up and made his season debut as the starting shortstop. Three days later on July 25, he switched his uniform number from 17 to 23 to accommodate the newly acquired Aramis Ramírez so Ramirez could wear number 17 since his longtime uniform number 16 was already being worn by first base coach Nick Leyva. On August 18, Florimon hit a walk-off triple against the Diamondbacks to give Bucs a 9–8 win in the 15th. The 2015 Season saw Florimon wear 3 different uniform numbers: 17 (July 22