that he was working on a sequel to The Human Centipede (First Sequence), as well as a possible third film depending upon its success. He said that the plot would follow on from the first film, but with a centipede made from 12 people as opposed to the three victims of the first. The tag-line would be "100% medically inaccurate", in contrast to his "100% medically accurate" claim for the first film. Six stated the sequel would be much more graphic and disturbing, making the first film seem like "My Little Pony compared with part two." Speculation regarding the plot of Full Sequence grew after the Weekend of Horrors convention in May 2010, when Ashlynn Yennie and Akihiro Kitamura, who had starred in First Sequence, hinted that their characters might return for the sequel despite their deaths in First Sequence. Additionally, Ashley C. Williams, whose character was left alive at the end of First Sequence, stated in September 2010 that she was shooting a horror film in Britain, which led to speculation from FEARnet that she is reprising her role of Lindsay. In a further interview, Yennie confirmed Six's statement that the sequel would contain "the blood and shit" which viewers did not see in the first film. Six was inspired to make the movie a metafilm after reporters kept asking him if he worried about people committing copycat crimes inspired by the first film. Although he had previously considered the concept for a possible sequel, the questions cemented his idea. According to Six, he intentionally made Full Sequence very different from First Sequence for two reasons. First, when he was writing the script of First Sequence, he knew people would want more "blood and shit" than is shown. Second, the two parts reflect the different characters: the coloured First Sequence, with a slow-moving camera, fit the story of Dr. Heiter, while Martin Lomax's character required a "dark and dirty" film. Six shot Full Sequence in colour, but "was always thinking about black and white" and realized while editing that it was "much scarier" that way. It was also Six's idea to have little dialogue in the film's second half, except for moans, screams, and whimpers. Principal photography for Full Sequence began in London in June 2010 with a largely British cast. A teaser trailer was released on 24 September, in which Six introduced Martin, a man wearing a cardboard