The Strange Affair of Uncle Harry is a 1945 American film noir drama film directed by Robert Siodmak and starring George Sanders as an aging bachelor who looks after his two sisters, one of whom tries to sabotage his romance with his co-worker. It is based on the play Uncle Harry by Thomas Job. Plot Harry Quincy (Sanders) is an amiable middle-aged man working as a designer in a fabric mill in the small New England town of Corinth. Younger people in the factory call him "Uncle Harry". He lives as a bachelor in a large house with his two sisters; Lettie (Fitzgerald) and Hester (MacGill). Lettie is pretty but spoiled, and idles days away in bed, feigning numerous ailments. Hester is a widow and is harder working. It is made clear that although the family was rich, the money was lost in the Depression. Everything is disrupted by the arrival of a new young female designer at the mill. Deborah (Raines) comes from New York City and is slim, elegant, and very well-dressed. She clearly likes Harry and he falls in love. When Deborah tells him she will be taking an extended trip to Europe with a male co-worker, he finally declares his love for her. They plan to get married and both live in the big family house, but this involves the sisters finding a new home. While this is not an issue for Hester, Lettie is very resistant. After several months of having their plans sabotaged, Deborah persuades Harry to run off to New York and just get married that evening. However, their plan is thwarted when Lettie collapses and is taken to hospital. Deborah makes Harry choose: Lettie or her. He chooses his sister and Deborah leaves, seemingly forever. Later he hears that she is marrying the other man from work. In Lettie's desk, Harry finds some poison. He learns she bought it just before their dog died, in case euthanasia was needed. One night, he slips the poison into Lettie's hot chocolate. Unfortunately, the cups get mixed up and it is Hester who drops dead. The housekeeper enters and, since the sisters were always arguing, assumes Lettie poisoned Hester. Harry allows the accusation to stand and, after a trial, Lettie is sentenced to hang. Harry has a change of heart and brings a written confession to the prison governor. However, he thinks Harry is just