The Fourteen Holy Helpers (, ) are a group of saints venerated together by Roman Catholic Christians because their intercession is believed to be particularly effective, especially against various diseases. This group of Nothelfer ("helpers in need") originated in the 14th century at first in the Rhineland, largely as a result of the epidemic (probably of bubonic plague) that became known as the Black Death. History of veneration Devotion to the fourteen Holy Helpers began in Rhineland, now part of Germany, in the time of the Black Death. Among the fourteen were three virgin martyrs. A German mnemonic for them says: Margaretha mit dem Wurm, Barbara mit dem Turm, Katharina mit dem Radl das sind die drei heiligen Madl. ("Margaret with the lindworm, Barbara with the tower, Catherine with the wheel, those are the three holy maids.") As the other saints began to be invoked along with these three virgin martyrs, they were represented together in works of art. Popular veneration of these saints often began in a monastery that held their relics. All of the saints except Giles were accounted martyrs. Saint Christopher and Saint Giles were invoked against the plague itself. Saint Denis was prayed to for relief from headache, Saint Blaise against ills of the throat, Saint Elmo, against abdominal maladies, Saint Barbara against fever, and Saint Vitus against epilepsy. Saint Pantaleon was the patron of physicians, Saint Cyriacus invoked against temptation on the deathbed, and Saints Christopher, Barbara, and Catherine for protection against a sudden and unprovided-for death. Saint Giles was prayed to for a good confession, and Saint Eustace as healer of family troubles. Domestic animals were also attacked by the plague, and so Saints George, Elmo, Pantaleon, and Vitus were invoked for their protection. Saint Margaret of Antioch is the patron of safe childbirth. As the saints' joint cultus spread in the fifteenth century, Pope Nicholas V attached indulgences to devotion of the Fourteen Holy Helpers, though these no longer apply. While each had a separate feast day, the Fourteen Holy Helpers were in some places celebrated as a group on 8 August, but this celebration never became part of the General Roman Calendar for universal veneration. When that calendar was revised in 1969, the individual celebrations of St Barbara, St Catherine of Alexandria, St Christopher, and St Margaret of Antioch were dropped, but in 2004 Pope John Paul II reinstated the 25 November