two molecules of glucuronic acid. The extracts from the root of the plant can be referred to as liquorice, sweet root, and glycyrrhiza extract. G. glabra grows in Europe and Western Asia. When administered orally, the product of glycyrrhetinic acid is found in human urine whereas GZA is not. This shows that glycyrrhetic acid is absorbed and metabolized in the intestines in humans. GZA is hydrolyzed to glycyrrhetic acid in the intestines by bacteria. For thousands of years, G. glabra has been used for medicinal purposes including indigestion and stomach inflammation. Some other medicinal uses are cough suppression, ulcer treatment, and as a laxative. Salts of GZA can also be used in many products as sweeteners and aromatizers. The major (roughly 90%) use of liquorice is in the tobacco industry. The rest is split evenly between food and pharmaceutics, at 5% of usage each. Liquorice extract is often found in many sweets and candies, some drugs, and beverages like root beer. It can also be used in chewing gum, tobacco products like snuff, and toothpaste. A high intake of liquorice can have many toxic effects. Hyper-mineralocorticosteroid syndrome can occur when the body retains sodium, loses potassium altering biochemical and hormonal activities. Some of these activities include lower aldosterone level, decline of the renin-angiotensin system and increased levels of the atrial natriuretic hormone in order to compensate the variations in homoeostasis. Some other symptoms of toxicity include electrolyte imbalance, edema, increased blood pressure, weight gain, heart problems, and weakness. Symptoms depend on the severity of toxicity. Some other complaints include fatigue, shortness of breath, kidney failure, and paralysis. In 2020, physicians reported a case of a man who died of cardiac arrest as a result of drastically low potassium levels. He had been eating a bag of black licorice a day for three weeks previously. Most adverse effects of liquorice poisoning are attributed to the mineralocorticoid effects of GZA. Depending on the dose and intake of liquorice, serious problems and even hospitalization can occur. People with previously existing heart or kidney problems may be more susceptible to GZA and liquorice poisoning. It is important to monitor the amount of liquorice consumed in order to prevent toxicity. It is difficult to determine a safe level, because the effects are affected by a variety of factors and vary from person to person. In the most sensitive individuals, daily intake of about GZA can