to adulthood, married and had children. Land and Purchases of Enslaved People in the Louisiana Territory In 1799, Manuel Lisa requested a land grant; according to his letter to the Spanish governor, Manuel wanted it "upon one of the banks of the River Missouri, in a place where may be found some small creek emptying into the said river, in order to facilitate the raising of cattle, and, with time, to be able to make shipments of salted and dried meat to the capital. After being awarded the grant, Manuel Lisa and his wife relocated to St. Louis, where they purchased a home on Second Street near the Mississippi River. In the late 1790s and early 1800s, Lisa purchased numerous enslaved people Early trade expeditions Lisa likely moved to St. Louis to enter the fur trade, the major part of the regional economy. By 1802, he had obtained a trade monopoly from French officials (the territory had traded hands again) with the Osage Nation. (The monopoly had formerly been held by Auguste Chouteau, a French colonist and first settler of St. Louis). But, after the Louisiana Purchase and annexation of the territory by the United States, Lisa's relationship with the new government officials was not as strong. He competed with Pierre Chouteau, a prominent member of the founding family, who had gained a position as a U.S. government Indian agent; Chouteau and his brother had gained their wealth and social positions through the fur trade and as merchants. Lisa had difficult relations with James Wilkinson, then-governor of U.S. Louisiana Territory. Later found to have been a secret agent of the Spanish Crown, Wilkinson denied Lisa's requests to establish trade routes to Santa Fe, New Mexico, which was still under Spanish colonial rule. In 1806, Wilkinson warned Zebulon Pike, undertaking Pike's Expedition, to prevent Lisa's efforts to make business connections to Santa Fe. Having been stymied by the government and the Chouteau family, Lisa began organizing a trade expedition to the upper Missouri River region. On the first expedition, which departed in April 1807, Lisa and his company of 42 men (including John Colter, George Drouillard or Benito Vázquez) moved up the Missouri until they reached the mouth of the Yellowstone River. After ascending the Yellowstone some , Lisa established a trading post on November 21 at the mouth of the Bighorn River in present-day Montana. Named Fort Raymond for his