Alexandria wrote in his commentary on it that "some men, from their birth, have a natural sense of repulsion from a woman; and those who are naturally so constituted do well not to marry". The select 144,000 referenced in the heavenly vision of John in Revelation 14:4 are "the ones who have not been defiled with women...they are the ones who follow the Lamb wherever He goes...these have been purchased from among men as first fruits to God and the Lamb. And no lie was found in their mouth; they are blameless." The First Council of Nicaea in 325 AD established 20 new laws called canons. The first of these was the prohibition of self castration. The Ethiopian eunuch, an early gentile convert encountered in Acts 8, has been described as an early gay Christian, based on the fact that the word "eunuch" in the Bible was not always used literally, as in Matthew 19:12. Female homosexuality In the Epistle to the Romans 1:26-27 (ESV), Paul writes, "For this reason God gave them up to dishonorable passions. For their women exchanged natural relations for those that are contrary to nature". This is the only known specific reference in the Bible to female homosexuality. Most interpreters assume that, due to the analogy with same-sex lust between males, Paul is referring to female same-sex behavior. This assumption is not conclusive, and it remains difficult to discern exactly what Paul meant by women exchanging natural intercourse for unnatural. Brooten cites both Anastasios and Augustine as explicitly rejecting the 'lesbian hypothesis' (p. 337). Hanks asserts that "not until John Chrysostom (ca 400 CE) does anyone (mis)interpret Romans 1:26 as referring to relations between two women" (p. 90). Townsley notes that other early writers, possibly including Chrysostom, reject the 'lesbian' hypothesis, specifically, Ambrosiaster, Didymus the Blind and Clement of Alexandria. Developmental sexuality Thomas E. Schmidt's dictionary entry on the topic concludes that a process of spirituality and sexuality are developmental in the life of Christian believers and proper instruction is towards "a growth in discipleship" rather than self-identity. Historical and cultural perspectives The history of Christianity and homosexuality has been much debated. The Hebrew Bible/Old Testament and its traditional interpretations in Judaism and Christianity have historically affirmed and endorsed a patriarchal and heteronormative approach towards human sexuality, favouring exclusively penetrative vaginal intercourse between men and women within the boundaries of marriage over all other forms