The Campaign for Science and Engineering (CaSE) is a non-profit organisation that is the UK's leading independent advocate for science and engineering. It focuses on arguing for more research funding, promoting a high-tech and knowledge-based economy, highlighting the need for top-quality science and maths education at all levels, and scrutinising the mechanisms by which government uses science and evidence. History The Campaign for Science and Engineering was founded as Save British Science (SBS) in January 1986. The organisation started out when 1,500 scientists banded together to pay for an advert in The Times. It called on the Prime Minister, Margaret Thatcher to 'Save British Science'. The organisation changed its name to the Campaign for Science and Engineering (CaSE) in 2005. Structure CaSE is based in London. It receives its funding from over 100 member organisations, which currently include companies such as Astra Zeneca, GlaxoSmithKline, and Johnson Matthey; universities such as the University of Oxford and University of Cambridge; learned and professional societies such as the Royal Society of Biology, Institute of Physics and Royal Society of Chemistry; and charities including the Wellcome Trust and Cancer Research UK. CaSE also has a large number of individual members. CaSE employs a team of staff who are led by the Executive Director, currently Prof Sarah Main. It also has a Board of Directors who meet several times each year to discuss CaSE's strategy and set its campaigning priorities, as well as being responsible for governance and financial management of the organisation. Professor Sir Ian Boyd is the current Chair of the Board. Activity CaSE focuses its activity in three priority areas; Education and Skills, Investment and Evidence in Policymaking, delivering independent analysis and recommendations for action in reports in these areas. Following the 2016 Brexit referendum, it has been a strong voice in the areas of immigration, collaboration and regulation which are of particular concern to the science and engineering sector. In 2010, CaSE played a key role in the Science is Vital campaign, which lobbied against cuts to the UK science budget in the Comprehensive Spending Review of October that year. The science budget was frozen in the final review. In 2017 CaSE called for increase in R&D investment and the government subsequently committed to increasing spending to 2.4% of GDP by 2027. Other successes include lobbying for amendments to the HE and Research Bill in 2016. CaSE holds regular meetings with