regulations FDA established labeling request for drugs and biological products with medication risks, allowing informed decision making for pregnant and breastfeeding women and their health care providers. Pregnancy category was required on the drug label for systemically absorbed medications with the risk of fetal injury, which is now replaced with pregnancy and lactation labeling rule (PLLR). In addition to pregnancy category requirements on information of pregnancy, labor and delivery, and nursing mothers, PLLR also includes information on females animals of reproductive potential. The labeling change were effective starting June 30, 2015. The labeling requirements of over-the-counter (OTC) medicines we not affected. Pharmacologic consideration The change in medication exposure during pregnancy should concern both mother and fetus independently. For example, within antibiotics, penicillin may be used during pregnancy, whereas tetracycline is not recommended due to potential risk of fetus for a wide range of adverse effects. Drugs Medications to reduce risk of miscarriage Progesterone is a medication often used to prevent threatened miscarriage. A threatened miscarriage is signs or symptoms of miscarriage, most often including bleeding that occurs in the first 20-weeks of a pregnancy. Research has shown that supplementation of progesterone can lower the rate of miscarriage, however, it did not have an effect on lowering the rate of pre-term births and live births. In reference to micronized vaginal progesterone, these results were more prominent for people who were at high risk of miscarriage, including people who have had three or more miscarriages and are currently experiencing bleeding. The use of low dose aspirin may be linked to increased rates of live births and fewer pregnancy losses for people who have had one or two miscarriages. The National Institute of Health has recently changed their stance on using low dose aspirin, stating "low-dose aspirin therapy before conception and during early pregnancy may increase pregnancy chances and live births among a person who has experienced one or two prior miscarriages." This is a change from the previous stance on aspirin preventing pregnancy loss from the National Institute of Health. The reasoning behind the change was the determination that adherence to the medication and not discontinuing low dose aspirin due to side effects "could improve the odds for pregnancy and live birth in this group of people." Sulfonamides and their risk of congenital malformations Some studies have shown that maternal exposure to sulfonamides during pregnancy may have an increased risk of congenital