Tony Parker (8) | AT&T Center16,888 | 5–6 |- bgcolor="#bbffbb" | 12 | November 23 | Milwaukee | | Tim Duncan (24) | Tim Duncan (12) | Tony Parker (6) | AT&T Center17,677 | 6–6 |- bgcolor="#bbffbb" | 13 | November 25 | Golden State | | Tony Parker (32) | Tim Duncan (10) | Tony Parker (7) | AT&T Center17,606 | 7–6 |- bgcolor="#bbffbb" | 14 | November 27 | @ Houston | | Tim Duncan (21) | Antonio McDyess (14) | Tony Parker (7) | Toyota Center18,164 | 8–6 |- bgcolor="#bbffbb" | 15 | November 29 | Philadelphia | | Tim Duncan (22) | DeJuan Blair (10) | Tony Parker (8) | AT&T Center17,161 | 9–6 |- bgcolor="#ffcccc" | 16 | December 3 | Boston | | DeJuan Blair (18) | Tim Duncan (15) | Tony Parker (7) | AT&T Center18,581 | 9–7 |- bgcolor="#ffcccc" | 17 | December 5 | Denver | | Tony Parker (27) | Matt Bonner (7) | Tony Parker (5) | AT&T Center17,592 | 9–8 |- bgcolor="#ffcccc" | 18 | December 7 | @ Utah | | Matt Bonner (28) | Tim Duncan (11) | Tony Parker (5) | EnergySolutions Arena17,565 | 9–9 |- bgcolor="#bbffbb" | 19 | December 9 | Sacramento | | Richard Jefferson (23) | Antonio McDyess (9) | Tony Parker (11) | AT&T Center17,353 | 10–9 |- bgcolor="#bbffbb" | 20 | December 11 | Charlotte | | Manu Ginóbili (22) | Tim Duncan (9) | Tony Parker (10) | AT&T Center17,508 | 11–9 |- bgcolor="#bbffbb" | 21 | December 13 | @ L.A Clippers | | Tim Duncan (21) | DeJuan Blair (9) | Tony Parker (7) | Staples Center16,464 | 12–9 |- bgcolor="#ffcccc" | 22 | December 15 | @ Phoenix | | Tim Duncan (34) | Tim Duncan (14) | Manu Ginóbili (6) | US Airways Center17,964 | 12–10 |- bgcolor="#bbffbb" | 23 | December 16 | @ Golden State | | Tim Duncan (27) | Tim Duncan (15) | Manu Ginóbili (5) | Oracle Arena17,857 | 13–10 |- bgcolor="#bbffbb" | 24 | December 19 | Indiana | | Tim Duncan (19) | Tim Duncan (16) | Tony Parker (4) | AT&T Center17,075 | 14–10 |- bgcolor="#bbffbb" | 25 | December 21 | L.A Clippers | | Tony Parker (19) | Theo Ratliff (7) | Roger Mason, Jr. (5) | AT&T Center17,451 | 15-10 |- bgcolor="#ffcccc" |