June 2011, McHale appeared in Katy Perry's music video for her song "Last Friday Night (T.G.I.F.)" as the character Everett McDonald. On July 22, 2012, McHale co-hosted the 2012 Teen Choice Awards with Demi Lovato. In January 2014, it was reported that McHale would host a comedy panel show, Virtually Famous, for the British digital television channel E4. The show features comedian Seann Walsh and radio presenter Chris Stark as series regulars and team captains. On February 24, 2014, it was announced that McHale had signed on to play a supporting role in the Kathy Bates and Dustin Hoffman led independent film Boychoir. McHale's character, Wooly, is a young music teacher who helps a troubled young boy at his school. In July 2014, it was announced that he and Aaron Tveit had signed on to star in the comedy film They Might Be Kennedys, but the film was postponed indefinitely in 2015 after the production was failed to be cast in time. McHale was cast to play one of the leads, Teddy Mulligan. In 2015, McHale competed with his mother, father, sister, and uncle on Celebrity Family Feud against Fred Willard. In April 2016, McHale joined the cast of Dustin Lance Black's drama miniseries When We Rise as AIDS activist Bobbi Campbell. In December 2020, McHale was a part of a mini musical music video called "Stay Inside". He co-starred alongside dancer Haley Fitzgerald. The song and video were written by the composers of the Broadway and West End musical Six, Toby Marlow and Lucy Moss. The video was choreographed by Kyle Hanagami. Viewers were encouraged to make donations to Broadway Cares/Equity Fights AIDS, the philanthropic heart of Broadway. On June 3, 2021 Ryan Murphy revealed McHale to be one of four actors starring in the upcoming spin-off series American Horror Stories. McHale starred alongside Dyllón Burnside of Pose, Charles Melton of Riverdale, and Nico Greetham of The Prom. Murphy announced the new cast via Instagram post where he dubbed the four men the Fantastic Four. The new series premiered on Hulu July 15, 2021 and concluded on Halloween. McHale played the role of Barry, a member of the fictional social media influencer group "The Bro House", in the fourth episode of the anthology series which was titled "The Naughty List". In December 2021, McHale was a part of an off-Broadway workshop for Radiant Baby, a musical about artist Keith