characters Main Alex O'Loughlin as Dr. Andrew "Andy" Yablonski, a cardiothoracic surgeon being groomed by Dr. Jordan to take over the transplant department Katherine Moennig as Dr. Miranda Foster, a surgical fellow from Philadelphia and daughter of Andy's former mentor Dr. William Foster Daniel Henney as Dr. David Lee, an ophthalmology resident and ladies' man Christopher Hanke as Ryan Abbott Justina Machado as Pam Acosta Amber Clayton as Dr. Lisa Reed Alfre Woodard as Dr. Sophia Jordan, the no-nonsense head of transplant Supporting Julia Ormond as Dr. Sophia Jordan, unaired pilot Britt Robertson as Brenda Stark Nicholas Braun as Michael Devika Parikh as Nurse Rekha/Nurse/ER Nurse/ER Nurse #2 Owiso Odera as Kuol/Kuol Adebe Ketebo Joe Holt as Bret/EMT/EMT Bret Puja Mohindra as EMT/EMT Lori Goel/Goel/Lori Goel/Marilyn/Medic #3 Claudia Choi as ICU Nurse/Nurse Chen Sabra Williams as Nurse Williams/ER Nurse #1/ER Nurse #2 Teri Reeves as Nurse Alicia/Alicia/Alicia Wilson/Nurse Bruce Katzman as Dr. Richard Strauss Mercedes Masöhn as Vanessa Shiloh Fernandez as Scott Barker/Scott Rizwan Manji as Dr. Dev/Dr. Drev/Male Doctor Louie Alegria as EMT/EMT #1/Medic #1 Paull Walia as Dr. Inder Patel Caryn West as Dr. Susan Heyworth William Sadler as Michael Zelasko Oded Fehr as Dr. Luc Bovell Kelly Overton as Det. Rena Yablonski John Bedford Lloyd as Dr. Yorn Omid Abtahi as Dr. Yousef Khouri B. J. Britt as Antoine/Anton Weathers Stacey Scowley as Bullpen Nurse/Bullpen nurse Brooklyn McLinn as ER Nurse/ER Nurse #1 Page Leong as Dr. Margolis/Female Doctor Kenny Champion as Eddie Baines/Pat Kathleen M. Darcy as Hepatologist Lynn Adrianna Freedman as ER Nurse #1/Nurse #1 Mustafa Haidari as Doctor Michelle Diaz as Nurse Liza Salazar/O.R. Nurse Aisha Kabia as Melissa Noah Fleiss as Sam Heaton Episodes References External links CBS original programming 2009 American television series debuts 2010 American television series endings Television shows set in Pittsburgh English-language television shows 2000s American medical television series 2010s American medical television series Television series by CBS Studios 2000s American drama television series 2010s American drama television series