LI 30 (Lysis Index after 30 minutes) and ML (Maximum Lysis) The LI30 value is the percentage of remaining clot stability in relation to the MCF value at 30 min after CT. A similar value can also be calculated at other time points (45 or 60 min). The ML parameter describes the percentage of lost clot stability (relative to MCF, in %) viewed at any selected time point or when the test has been stopped. A low LI (X) value or a high ML value indicates hyperfibrinolysis. While in normal blood fibrinolysis activity is quite low, in clinical samples a more rapid loss of clot stability by hyperfibrinolysis may lead to bleeding complications which can be treated by the administration of antifibrinolytic drugs. TEM assays Initially, thrombelastography was simply performed with whole blood without adding reagents (except calcium when citrate anticoagulated blood was used). This provides a global overview about all phases of clot formation, stabilization and degradation. In the case of monocausal haemostasis disorders, the resulting reaction curves may be quite typical; however, under most clinical conditions this approach has severe limitations. In reality various effects overlap, including haemodilution or application of high doses of parenteral anticoagulants. High doses of heparin often prevent clot formation at all. Absence of a controlled activation step leads to inferior reproducibility and very long test times which are not acceptable for POC applications. The assays for ROTEM analysis help to get a rapid differentiation between various potential haemostasis defects or anticoagulant drug effects and allow for a rapid differential diagnosis. They form the base for selecting a therapeutic strategy. Several diagnostic algorithms have been proposed and were clinically validated. Application of this strategy helps to minimize the exposure of patients to allogeneic blood products which have certain risks; and it saves costs. Numerous research applications have used the technique as well. Tests INTEM This test mildly activates the contact phase of haemostasis. The result is influenced by coagulation factors, platelets, fibrinogen and heparin. Low molecular weight heparin is detected at higher concentrations. In the absence of heparin, INTEM is a screening test for the haemostasis system. It is used for therapeutic decisions regarding the administration of fresh frozen plasma, coagulation factors, fibrinogen or platelets. HEPTEM This assay represents an INTEM assay performed in the presence of heparinase, a heparin (or LMWH) degrading enzyme. It allows the identification of haemostasis deficiencies even in the