substrates of AKT. Gene The TSC1 gene is located on chromosome 9q34 and encodes the 130 kDa protein hamartin containing 1163 amino acids. The TSC2 gene is located on chromosome 16p13.3 and codes for the 200 kDa protein tuberin containing 1807 amino acids. Protein structure The following functions of tuberin have been identified: GTPase-accelerating protein (GAP) function for the Rap1a GTPase. C-terminal transcriptional activation domains. Selective modulation of transcription mediated by members of the steroid receptor superfamily. References Further reading Tor signaling pathway Human proteins