Sharpless is a surname. Notable people with the surname include: Bevan Sharpless, solar system astronomer Karl Barry Sharpless, American chemist and Nobel prize winner Josh Sharpless, baseball player Christopher Sharpless, 1988 Winter Olympics bobsledder Mattie R. Sharpless (born 1942), American diplomat Stewart Sharpless, galactic astronomer Sharpless catalog, a 20th-century astronomical catalog with 313 items Isaac Sharpless, educator Norman Sharpless, American oncologist and director of the National Cancer Institute Disappearance of Toni Sharpless, an American nurse who disappeared in 2009 Fictional characters A character in Madama Butterfly See also Sharpless asymmetric dihydroxylation, a chemical reaction Sharpless epoxidation, a chemical reaction Sharpless oxyamination, a chemical reaction