19 | Golden State | | Manu Ginóbili (23) | DeJuan Blair (9) | Manu Ginóbili (11) | AT&T Center18,581 | 41–26 |- bgcolor="#ffcccc" | 68 | March 21 | @ Atlanta | (OT) | Manu Ginóbili (38) | Tim Duncan (13) | Manu Ginóbili (6) | Philips Arena18,729 | 41–27 |- bgcolor="#bbffbb" | 69 | March 22 | @ Oklahoma City | | George Hill (27) | Tim Duncan, Antonio McDyess (7) | Tim Duncan, Manu Ginóbili (5) | Ford Center18,203 | 42–27 |- bgcolor="#ffcccc" | 70 | March 24 | L.A Lakers | | Manu Ginóbili (24) | Tim Duncan (12) | Tim Duncan (6) | AT&T Center18,581 | 42–28 |- bgcolor="#bbffbb" | 71 | March 26 | Cleveland | | Manu Ginóbili (30) | George Hill (9) | George Hill, Manu Ginóbili (6) | AT&T Center18,581 | 43–28 |- bgcolor="#bbffbb" | 72 | March 28 | @ Boston | | Manu Ginóbili (28) | Richard Jefferson, DeJuan Blair (11) | Manu Ginóbili (7) | TD Garden18,624 | 44–28 |- bgcolor="#ffcccc" | 73 | March 29 | @ New Jersey | | George Hill (19) | Tim Duncan (12) | Richard Jefferson (5) | IZOD Center13,053 | 44–29 |- bgcolor="#bbffbb" | 74 | March 31 | Houston | | George Hill (30) | Tim Duncan (10) | Manu Ginóbili (10) | AT&T Center18,581 | 45–29 |- bgcolor="#bbffbb" | 75 | April 2 | Orlando | | Manu Ginóbili (43) | Tim Duncan (8) | George Hill (9) | AT&T Center18,581 | 46–29 |- bgcolor="#bbffbb" | 76 | April 4 | @ L.A Lakers | | Manu Ginóbili (32) | Tim Duncan (11) | Manu Ginóbili (5) | Staples Center18,997 | 47–29 |- bgcolor="#bbffbb" | 77 | April 6 | @ Sacramento | | Richard Jefferson (18) | Antonio McDyess (11) | Manu Ginóbili (6) | ARCO Arena17,312 | 48–29 |- bgcolor="#ffcccc" | 78 | April 7 | @ Phoenix | | Roger Mason, Jr. (18) | DeJuan Blair (8) | Tony Parker (5) | US Airways Center18,422 | 48–30 |- bgcolor="#ffcccc" | 79 | April 9 | Memphis | | Manu Ginóbili (26) | Tim Duncan (10) | Tony Parker (8) | AT&T Center18,581 | 48–31 |- bgcolor="#bbffbb" | 80 | April 10 | @ Denver | | Tim Duncan (18) | Tim Duncan (10) | Manu Ginóbili (7) | Pepsi Center19,155 | 49–31 |- bgcolor="#bbffbb" | 81