Tim Duncan (8) | Manu Ginóbili (7) | FedExForum14,116 | 24–15 |- bgcolor="#bbffbb" | 40 | January 18 | @ New Orleans | | Tony Parker (25) | Tim Duncan (14) | Manu Ginóbili (6) | New Orleans Arena16,549 | 25–15 |- bgcolor="#ffcccc" | 41 | January 20 | Utah | | Manu Ginóbili (22) | DeJuan Blair (11) | Manu Ginóbili (8) | AT&T Center17,584 | 25–16 |- bgcolor="#ffcccc" | 42 | January 22 | Houston | | Tim Duncan (25) | Tim Duncan (14) | Tony Parker (10) | AT&T Center18,581 | 25–17 |- bgcolor="#ffcccc" | 43 | January 25 | Chicago | | Tony Parker (20) | DeJuan Blair (11) | Tony Parker (8) | AT&T Center18,581 | 25–18 |- bgcolor="#bbffbb" | 44 | January 27 | Atlanta | | Tim Duncan (21) | Tim Duncan (27) | Tony Parker (8) | AT&T Center18,258 | 26–18 |- bgcolor="#bbffbb" | 45 | January 29 | Memphis | | Tim Duncan (19) | DeJuan Blair (10) | Tim Duncan, Manu Ginóbili (7) | AT&T Center18,088 | 27–18 |- bgcolor="#ffcccc" | 46 | January 31 | Denver | | George Hill (17) | Tim Duncan (10) | Manu Ginóbili (9) | AT&T Center17,607 | 27–19 |- bgcolor="#bbffbb" | 47 | February 3 | @ Sacramento | | George Hill (23) | Tim Duncan (13) | George Hill (9) | ARCO Arena12,934 | 28–19 |- bgcolor="#ffcccc" | 48 | February 4 | @ Portland | | Manu Ginóbili (21) | Tim Duncan (12) | Tony Parker (6) | Rose Garden20,572 | 28–20 |- bgcolor="#bbffbb" | 49 | February 6 | @ L.A Clippers | | George Hill (22) | Antonio McDyess (10) | Tony Parker (14) | Staples Center18,258 | 29–20 |- bgcolor="#ffcccc" | 50 | February 8 | @ L.A Lakers | | Manu Ginóbili (21) | Tim Duncan (15) | Tony Parker (8) | Staples Center18,997 | 29–21 |- bgcolor="#bbffbb" | 51 | February 11 | @ Denver | | George Hill, DeJuan Blair (17) | DeJuan Blair (9) | Manu Ginóbili (6) | Pepsi Center18,611 | 30–21 |- align="center" |colspan="9" bgcolor="#bbcaff"|All-Star Break |- bgcolor="#bbffbb" | 52 | February 17 | @ Indiana | | Tony Parker (28) | Tim Duncan (26) | Manu Ginóbili (7) | Conseco Fieldhouse14,947 | 31–21 |- bgcolor="#ffcccc" | 53 | February 19 | @ Philadelphia | | Manu Ginóbili (24) | Tim Duncan