anorectal and 3D HRM Manometry. Sierra Scientific also provides the AccuTrac pH and pH-Impedance Monitoring System, pH and pH-Z disposable catheters and ManoShield disposable catheter sheaths for both esophageal and anorectal catheters. Additionally, Sierra Scientific offers the Polygraf ID stationary gastrointestinal function testing platform and the Digitrapper(R) ambulatory pH monitoring system. Headquarters and plants The company's corporate headquarters, research and development laboratories, and manufacturing facilities are located in Yokneam, Israel. It maintains offices in Duluth, Georgia and Heerlen, Netherlands. Additional sales and marketing offices are located in France, Japan, Australia, and Singapore. The company also has a plant in Ireland. Given Imaging's wholly owned subsidiary, Sierra Scientific Instruments, is located in Los Angeles, California, with manufacturing operations in Vietnam. See also Science and technology in Israel Health care in Israel List of Israeli inventions and discoveries Silicon Wadi Startup Village, Yokneam References Gastroenterology Optics manufacturing companies Medical technology companies of Israel Companies formerly listed on the Nasdaq Companies established in 1998 Israeli inventions