Mo Williams (17) | Anderson Varejão (9) | Mo Williams (8) | Quicken Loans Arena20,562 | 50–15 |- align="center" bgcolor="#ccffcc" | 66 | March 12 | @ Philadelphia | | LeBron James (23) | Anderson Varejão (12) | LeBron James (10) | Wachovia Center20,433 | 51–15 |- align="center" bgcolor="#ccffcc" | 67 | March 14 | Boston | | LeBron James (30) | Antawn Jamison (12) | LeBron James (7) | Quicken Loans Arena20,562 | 52–15 |- align="center" bgcolor="#ccffcc" | 68 | March 16 | @ Detroit | | LeBron James (29) | LeBron James (12) | LeBron James (12) | The Palace of Auburn Hills22,076 | 53–15 |- align="center" bgcolor="#ccffcc" | 69 | March 17 | Indiana | | LeBron James (32) | LeBron James, Antawn Jamison (9) | LeBron James (9) | Quicken Loans Arena20,562 | 54–15 |- align="center" bgcolor="#ccffcc" | 70 | March 19 | @ Chicago | | LeBron James (29) | LeBron James (11) | LeBron James (7) | United Center23,129 | 55–15 |- align="center" bgcolor="#ccffcc" | 71 | March 21 | Detroit | | Leon Powe (16) | Anderson Varejão (9) | Mo Williams (8) | Quicken Loans Arena20,562 | 56–15 |- align="center" bgcolor="#ccffcc" | 72 | March 24 | @ New Orleans | | LeBron James (38) | Antawn Jamison (11) | LeBron James (9) | New Orleans Arena18,008 | 57–15 |- align="center" bgcolor="#ffcccc" | 73 | March 26 | @ San Antonio | | LeBron James (27) | Antawn Jamison (9) | LeBron James (10) | AT&T Center18,581 | 57–16 |- align="center" bgcolor="#ccffcc" | 74 | March 28 | Sacramento | | LeBron James (34) | Antawn Jamison (9) | LeBron James (8) | Quicken Loans Arena20,562 | 58–16 |- align="center" bgcolor="#ccffcc" | 75 | March 31 | Milwaukee | | LeBron James (23) | Antawn Jamison (12) | LeBron James (7) | Quicken Loans Arena20,562 | 59–16 |- align="center" bgcolor="#ccffcc" | 76 | April 2 | Atlanta | | LeBron James (27) | J. J. Hickson (16) | LeBron James (6) | Quicken Loans Arena20,562 | 60–16 |- align="center" bgcolor="#ffcccc" | 77 | April 4 | @ Boston | | LeBron James (42) | J. J. Hickson (11) | LeBron James (9) | TD Garden18,624 | 60–17 |- align="center" bgcolor="#ccffcc" | 78 | April 6 | Tornto | | Antawn Jamison (20) | Anthony Parker (8) | LeBron James (13) | Quicken