29 | Indiana | | Derrick Rose (28) | Tyrus Thomas (15) | Derrick Rose (6) | United Center21,887 | 12–17 |- bgcolor="#bbffbb" | 30 | December 31 | @ Detroit | | Derrick Rose (22) | Joakim Noah (21) | Kirk Hinrich (6) | The Palace of Auburn Hills22,076 | 13–17 |- bgcolor="#bbffbb" | 31 | January 2 | Orlando | | Derrick Rose (30) | Taj Gibson (12) | Derrick Rose (7) | United Center21,162 | 14–17 |- bgcolor="#ffcccc" | 32 | January 4 | Oklahoma | | Derrick Rose (19) | Joakim Noah (14) | Derrick Rose, Kirk Hinrich (7) | United Center18,838 | 14–18 |- bgcolor="#ffcccc" | 33 | January 5 | @ Charlotte | | Derrick Rose (24) | Luol Deng (9) | Derrick Rose (9) | Time Warner Cable Arena13,749 | 14–19 |- bgcolor="#ffcccc" | 34 | January 8 | @ Milawaukee | | Derrick Rose (25) | Joakim Noah (18) | Derrick Rose (9) | Bradley Center18,717 | 14–20 |- bgcolor="#bbffbb" | 35 | January 9 | Minnesota | | Joakim Noah, Kirk Hinrich (20) | Joakim Noah, Taj Gibson (9) | Derrick Rose, Kirk Hinrich (7) | United Center20,255 | 15–20 |- bgcolor="#bbffbb" | 36 | January 11 | Detroit | | Luol Deng (27) | Joakim Noah (11) | Derrick Rose (9) | United Center21,014 | 16–20 |- bgcolor="#bbffbb" | 37 | January 14 | @ Boston | | Luol Deng (25) | Joakim Noah (11) | Kirk Hinrich (6) | TD Garden18,624 | 17–20 |- bgcolor="#bbffbb" | 38 | January 15 | Washington | | Derrick Rose (37) | Joakim Noah (15) | Derrick Rose (6) | United Center20,304 | 18–20 |- bgcolor="#ffcccc" | 39 | January 18 | @ Golden State | | John Salmons (37) | Joakim Noah (16) | Derrick Rose, John Salmons, Jannero Pargo (4) | Oracle Arena19,208 | 18–21 |- bgcolor="#ffcccc" | 40 | January 20 | @ L.A. Clippers | | Derrick Rose (23) | Joakim Noah (15) | Derrick Rose (7) | Staples Center16,794 | 18–22 |- bgcolor="#bbffbb" | 41 | January 22 | @ Phoenix | | Derrick Rose (32) | Joakim Noah, Taj Gibson (8) | Derrick Rose, Kirk Hinrich (5) | US Airways Center18422 | 19–22 |- bgcolor="#bbffbb" | 42 | January 23 | @ Houston | | Brad Miller (25) | Taj Gibson (14) | Kirk Hinrich (7) |