Helicobacter cinaedi is a bacterium in the family Helicobacteraceae, Campylobacterales order, Helicobacteraceae family, Helicobacter genus. It was formerly known as Campylobacter cinaedi until molecular analysis published in 1991 led to a major revision of the genus Campylobacter. H. cinaedi is a curved, spiral (i.e. S-shaped), or fusiform (i.e. spindle-shaped) rod with flagellum at both of its ends (i.e. bipolar flagella) which it uses to dart around. The bacterium is a pathogen. Like many other species in the Helicobacter genus (see Helicobacter heilmannii sensu lato), H. cinaedi infects not only animals, but also humans. While common in animals, it was once thought to be an extremely rare infection in humans and to occur almost always in those who are immunocompromised. However,H. cinaedi infections are now regarded as more common than previously thought and to occur not only in immunocompromised individuals, but also in individuals suffering various types of medical conditions that are not associated with defective immunity, in patients as part of a nosocomial (i.e. hospital-acquired) infection, and, to a lesser extent, in immunocompetent individuals who have no known predisposing medical conditions. In particular, studies conducted in Japan indicate that H. cinaedi infections can occur in groups of individuals who are associated with each other in nonhospital and nonmedical settings. These community-acquired infections occur principally in immunocompetent individuals. While many H. cinaedi infections in humans involve the gastrointestinal tract and may have a remitting and relapsing course, some of these infections spread to the blood to cause life-threatening bacteremia. This is particularly the case in hospital-borne/medical setting infections that occur in immunocompromised individuals, those with H. cinaedi bacteremia, particularly those who acquire it in a community setting, typically display no life-threatening or other symptoms except fever. In any event, even the severest cases of H. cinaedi infections, especially those occurring in immunocompetent individuals who acquire the bacterium in a community setting, have been successfully treated with antibiotics. Epidemiology and transmission to humans Helicobacter cinaedi has been isolated from cats, dogs, hamsters, rats, foxes, and rhesus monkeys; the bacterium is part of the normal intestinal bacterial flora of hamsters. Many species of Helicobacter such as the five species of H. heilmannii sensu lato are transmitted to humans by close contact with infected animals. Reports have suggested that humans are likewise infected with H. cinaedi by direct contact (i.e. zoonotic transmission) with animals (particularly hamsters and farm animals) harboring the bacterium. However, there