to treat seizure disorders gained increased attention with a number of media reports in 2012 and 2013, and by the end of 2015 sixteen states had "low-THC, high-CBD" laws in effect. Currently 11 states are considered to have low-THC, high-CBD laws. These laws vary in THC content allowed all the way up to 5% in Georgia and Kansas. Research As a Schedule I drug in the U.S., clinical research on cannabis must be approved by the Food and Drug Administration, and a license (also referred to as a "registration") must be obtained from the Drug Enforcement Administration specific to conducting research on Schedule I drugs. The petition to the FDA is submitted in the form of an Investigational New Drug application, which the FDA has 30 days to respond to. DEA research registrations are issued for Schedule I and Schedule II–V drugs, with the Schedule I registration mandating stricter compliance requirements such as the manner in which substances are stored and secured. The DEA has 60 days to respond to registration applications as required by the 2022 Medical Marijuana and Cannabidiol Research Expansion Act. Prior to the act, researchers reported that the application process sometimes took over a year. In addition to FDA approval and DEA registration, other requirements have been imposed for cannabis research that do not exist for any other drug, which has had a significant effect in limiting the amount of research conducted. One such requirement was established in 1999 when it was mandated that all proposed research be submitted to the U.S. Public Health Service for approval. This was of particular burden to researchers as there was no timeline in which PHS was required to respond, with some reviews taking years to complete. In June 2015 the PHS review was eliminated, however, to better streamline the process for approving medical cannabis research. Prior to 2021, clinical research on cannabis also required the approval of the National Institute on Drug Abuse. The stated mission of NIDA is to support research on the causes, consequences, prevention, and treatment of drug abuse and drug addiction, and not the medicinal uses of drugs. Consequently, many studies on the therapeutic benefits of cannabis were either denied or altered to comply with the limited scope and mission of NIDA. There is also no timeline in which NIDA is required to respond to proposals (as with the PHS review), which has resulted in