10 | @ Portland | | LeBron James (41) | Shaquille O'Neal (11) | LeBron James (8) | Rose Garden Arena20,614 | 29–10 |- align="center" bgcolor="#ccffcc" | 40 | January 11 | @ Golden State | | LeBron James (37) | Anderson Varejão, Zydrunas Ilgauskas (9) | LeBron James (11) | Oracle Arena19,596 | 30–10 |- align="center" bgcolor="#ffcccc" | 41 | January 14 | @ Utah | | LeBron James (36) | LeBron James, Anderson Varejão (9) | LeBron James (6) | EnergySolutions Arena19,911 | 30–11 |- align="center" bgcolor="#ccffcc" | 42 | January 16 | @ L.A. Clippers | | LeBron James (32) | Anderson Varejão (9) | Mo Williams (6) | Staples Center19,277 | 31–11 |- align="center" bgcolor="#ccffcc" | 43 | January 19 | Toronto | | LeBron James (28) | LeBron James (9) | LeBron James (11) | Quicken Loans Arena20,562 | 32–11 |- align="center" bgcolor="#ccffcc" | 44 | January 21 | L.A. Lakers | | LeBron James (37) | J.J. Hickson (14) | LeBron James (9) | Quicken Loans Arena20,562 | 33–11 |- align="center" bgcolor="#ccffcc" | 45 | January 23 | Oklahoma City | | LeBron James (37) | LeBron James, J.J. Hickson (9) | LeBron James (12) | Quicken Loans Arena20,562 | 34–11 |- align="center" bgcolor="#ccffcc" | 46 | January 25 | @ Miami | | LeBron James (32) | Anderson Varejão (10) | LeBron James (4) | AmericanAirlines Arena19,600 | 35–11 |- align="center" bgcolor="#ccffcc" | 47 | January 27 | Minnesota | | J.J. Hickson (23) | Anderson Varejão (10) | LeBron James (11) | Quicken Loans Arena20,562 | 36–11 |- align="center" bgcolor="#ccffcc" | 48 | January 29 | @ Indiana | | LeBron James, Shaquille O'Neal (22) | LeBron James, Anderson Varejão (9) | LeBron James (13) | Conseco Fieldhouse18,165 | 37–11 |- align="center" bgcolor="#ccffcc" | 49 | January 31 | L.A. Clippers | | LeBron James (32) | Shaquille O'Neal (12) | LeBron James (11) | Quicken Loans Arena20,562 | 38–11 |- align="center" bgcolor="#ccffcc" | 50 | February 2 | Memphis | | LeBron James (22) | Shaquille O'Neal (13) | LeBron James (15) | Quicken Loans Arena20,562 | 39–11 |- align="center" bgcolor="#ccffcc" | 51 | February 4 | Miami | | LeBron James (36) | Shaquille O'Neal (8) | LeBron James (8) | Quicken Loans Arena20,562 | 40–11 |- align="center" bgcolor="#ccffcc" | 52 | February 6 | New York | | LeBron