align="center" bgcolor="#ffbbbb" | 8 || October 21 || Boston Celtics || 96 – 82 || || || ||Value City Arena18,021 || 4-4 recap |- Regular season Standings Record vs. opponents Game log |- align="center" bgcolor="#ffcccc" | 1 | October 27 | Boston | | LeBron James (38) | Shaquille O'Neal (10) | LeBron James (8) | Quicken Loans Arena20,562 | 0–1 |- align="center" bgcolor="#ffcccc" | 2 | October 28 | @ Toronto | | LeBron James (23) | LeBron James (11) | LeBron James (12) | Air Canada Centre20,152 | 0–2 |- align="center" bgcolor="#ccffcc" | 3 | October 30 | @ Minnesota | | LeBron James (24) | Anderson Varejão (11) | LeBron James, Mo Williams (6) | Target Center19,356 | 1–2 |- align="center" bgcolor="#ccffcc" | 4 | October 31 | Charlotte | | Mo Williams (24) | Anderson Varejão (8) | LeBron James (9) | Quicken Loans Arena20,562 | 2–2 |- align="center" bgcolor="#ccffcc" | 5 | November 3 | Washington | | LeBron James (27) | Anderson Varejão (10) | LeBron James, Mo Williams (6) | Quicken Loans Arena20,562 | 3-2 |- align="center" bgcolor="#ffcccc" | 6 | November 5 | Chicago | | LeBron James (25) | Anderson Varejão (13) | LeBron James, Mo Williams (6) | Quicken Loans Arena20,562 | 3–3 |- align="center" bgcolor="#ccffcc" | 7 | November 6 | @ New York | | LeBron James (33) | Anderson Varejão (14) | LeBron James (9) | Madison Square Garden19,763 | 4–3 |- align="center" bgcolor="#ccffcc" | 8 | November 11 | @ Orlando | | LeBron James (36) | LeBron James (8) | Mo Williams (6) | Amway Arena17,461 | 5–3 |- align="center" bgcolor="#ccffcc" | 9 | November 12 | @ Miami | | LeBron James (34) | Jamario Moon (6) | LeBron James (7) | American Airlines Arena19,600 | 6–3 |- align="center" bgcolor="#ccffcc" | 10 | November 14 | Utah | | LeBron James, Mo Williams (21) | LeBron James, Zydrunas Ilgauskas (6) | LeBron James (9) | Quicken Loans Arena20,562 | 7–3 |- align="center" bgcolor="#ccffcc" | 11 | November 17 | Golden State | | LeBron James (31) | J.J. Hickson (9) | LeBron James (12) | Quicken Loans Arena20,562 | 8–3 |- align="center" bgcolor="#ffcccc" | 12 | November 18 | @ Washington | | LeBron James (34) | Zydrunas Ilgauskas (9) | LeBron James (8) | Verizon Center20,173 | 8–4 |- align="center" bgcolor="#ccffcc" | 13