| November 20 | @ Indiana | | LeBron James (40) | Zydrunas Ilgauskas (11) | LeBron James (7) | Conseco Fieldhouse18,165 | 9–4 |- align="center" bgcolor="#ccffcc" | 14 | November 21 | Philadelphia | | LeBron James (32) | Zydrunas Ilgauskas (8) | LeBron James (9) | Quicken Loans Arena20,562 | 10–4 |- align="center" bgcolor="#ccffcc" | 15 | November 25 | @ Detroit | | LeBron James (34) | LeBron James, Anderson Varejão (8) | Mo Williams (8) | The Palace of Auburn Hills22,076 | 11–4 |- align="center" bgcolor="#ffcccc" | 16 | November 27 | @ Charlotte | | LeBron James (25) | Anderson Varejão (11) | Mo Williams (6) | Time Warner Cable Arena 19,168 | 11–5 |- align="center" bgcolor="#ccffcc" | 17 | November 28 | Dallas | | LeBron James, Mo Williams (25) | Jamario Moon, Anderson Varejão (9) | LeBron James (12) | Quicken Loans Arena 20,562 | 12–5 |- align="center" bgcolor="#ccffcc" | 18 | December 2 | Phoenix | | Zydrunas Ilgauskas (14) | Shaquille O'Neal (9) | LeBron James (10) | Quicken Loans Arena20,562 | 13–5 |- align="center" bgcolor="#ccffcc" | 19 | December 4 | Chicago | | LeBron James (23) | Zydrunas Ilgauskas, Shaquille O'Neal (7) | LeBron James (11) | Quicken Loans Arena20,562 | 14–5 |- align="center" bgcolor="#ccffcc" | 20 | December 6 | @ Milwaukee | | Delonte West (21) | Anderson Varejão (12) | LeBron James (10) | Bradley Center16,625 | 15–5 |- align="center" bgcolor="#ffcccc" | 21 | December 8 | @ Memphis | | LeBron James (43) | LeBron James (13) | Mo Williams (8) | FedEx Forum16,325 | 15–6 |- align="center" bgcolor="#ffcccc" | 22 | December 9 | @ Houston | | LeBron James (27) | Shaquille O'Neal, J. J. Hickson (10) | LeBron James (7) | Toyota Center18,200 | 15–7 |- align="center" bgcolor="#ccffcc" | 23 | December 11 | Portland | | LeBron James (33) | Shaquille O'Neal (11) | Mo Williams (10) | Quicken Loans Arena20,562 | 16–7 |- align="center" bgcolor="#ccffcc" | 24 | December 13 | @ Oklahoma City | | LeBron James (44) | Anderson Varejão (10) | LeBron James (6) | Ford Center18,203 | 17–7 |- align="center" bgcolor="#ccffcc" | 25 | December 15 | New Jersey | | LeBron James (23) | Mo Williams, Jamario Moon (8) | LeBron James (7) | Quicken Loans Arena20,562 | 18–7 |- align="center" bgcolor="#ccffcc" | 26 |