approval in 1985 for treatment of nausea and vomiting associated with chemotherapy, and additionally in 1992 as an appetite stimulant for treatment of AIDS-related weight loss. It was initially classified as a Schedule II drug until it was moved to Schedule III in 1999. Marinol was developed by Unimed Pharmaceuticals, although initial research on the drug was mostly funded by the U.S. government. Unimed Pharmaceuticals was acquired by Solvay Pharmaceuticals in 1999. Syndros Syndros is a liquid oral formulation of dronabinol approved for treatment of nausea and vomiting related to chemotherapy and weight loss associated with AIDS. Syndros received FDA approval in July 2016 and was assigned a Schedule II classification by the DEA in March 2017. Syndros is manufactured by Insys Therapeutics, which received attention in 2016 for contributing heavily to the defeat of a cannabis legalization measure in Arizona, in an apparent attempt to protect market share for the newly developed drug. Syndros became available for prescription use in July 2017. Nabilone Nabilone is a synthetic cannabinoid similar to THC in molecular structure. It is sold in pill form only as the drug Cesamet. Cesamet Cesamet received FDA approval in 1985 for treatment of chemotherapy-induced nausea and vomiting. It was discontinued by its manufacturer Eli Lilly in 1989 for commercial reasons, and in 2004 U.S. rights to the drug were sold to Valeant Pharmaceuticals. In 2006 Valeant received FDA approval to resume sales. Cesamet has remained a Schedule II drug since its first introduction. Cannabidiol Cannabidiol (CBD) is a non-psychoactive cannabinoid extracted from the cannabis plant. It has received FDA approval as the drug Epidiolex. Epidiolex Epidiolex is a liquid oral formulation of cannabidiol. It received FDA approval for treatment of seizures associated with Dravet syndrome and Lennox–Gastaut syndrome in June 2018, and was assigned a Schedule V classification by the DEA in September 2018. Epidiolex is manufactured by Greenwich Biosciences, a U.S. subsidiary of the British firm GW Pharmaceuticals. Epidiolex became available for prescription use in November 2018. In April 2020, the DEA removed Epidiolex from the list of federally controlled substances. In August 2020, Epidiolex was approved for treatment of seizures associated with tuberous sclerosis complex. Non-prescription use In addition to its use for treatment of seizure disorders, cannabidiol is used by some individuals under the belief that it possesses a number of other medical properties – but these claims have yet to be thoroughly studied