Loans Arena20,562 | 61–17 |- align="center" bgcolor="#ffcccc" | 79 | April 8 | @ Chicago | | Mo Williams (35) | Antawn Jamison, Anthony Parker (6) | Mo Williams (10) | United Center21,707 | 61–18 |- align="center" bgcolor="#ffcccc" | 80 | April 9 | Indiana | | J. J. Hickson, Sebastian Telfair (21) | J. J. Hickson (10) | Delonte West (12) | Quicken Loans Arena20,562 | 61–19 |- align="center" bgcolor="#ffcccc" | 81 | April 11 | Orlando | | Delonte West (21) | Žydrūnas Ilgauskas (12) | Mo Williams (9) | Quicken Loans Arena20,562 | 61–20 |- align="center" bgcolor="#ffcccc" | 82 | April 14 | @ Atlanta | | Jamario Moon (15) | Jamario Moon (7) | Sebastian Telfair (5) | Philips Arena19,069 | 61–21 |- Playoffs |- align="center" bgcolor="#ccffcc" | 1 | April 17 | Chicago | W 96–83 | LeBron James (24) | Anderson Varejão (15) | Mo Williams (10) | Quicken Loans Arena20,562 | 1–0 |- align="center" bgcolor="#ccffcc" | 2 | April 19 | Chicago | W 112–102 | LeBron James (40) | LeBron James (8) | LeBron James (8) | Quicken Loans Arena20,562 | 2–0 |- align="center" bgcolor="#ffcccc" | 3 | April 22 | @ Chicago | L 106–108 | LeBron James (39) | Antawn Jamison (11) | LeBron James (8) | United Center22,991 | 2–1 |- align="center" bgcolor="#ccffcc" | 4 | April 25 | @ Chicago | W 121–98 | LeBron James (37) | LeBron James (12) | LeBron James (11) | United Center22,991 | 3–1 |- align="center" bgcolor="#ccffcc" | 5 | April 27 | Chicago | W 96–94 | Antawn Jamison (25) | LeBron James (10) | LeBron James (9) | Quicken Loans Arena20,562 | 4–1 |- |- align="center" bgcolor="#ccffcc" | 1 | May 1 | Boston | W 101–93 | LeBron James (35) | Antawn Jamison (9) | LeBron James (7) | Quicken Loans Arena20,562 | 1–0 |- align="center" bgcolor="#ffcccc" | 2 | May 3 | Boston | L 86–104 | LeBron James (24) | James, Varejão (7) | Mo Williams (7) | Quicken Loans Arena20,562 | 1–1 |- align="center" bgcolor="#ccffcc" | 3 | May 7 | @ Boston | W 124–95 | LeBron James (38) | Antawn Jamison (12) | James, Williams (7) | TD Garden18,624 | 2–1 |- align="center" bgcolor="#ffcccc" | 4 | May 9 | @ Boston | L 87–97 | LeBron James (22) | LeBron James (9) |