December 16 | @ Philadelphia | | LeBron James (36) | Shaquille O'Neal (9) | LeBron James (7) | Wachovia Center19,517 | 19–7 |- align="center" bgcolor="#ccffcc" | 27 | December 18 | Milwaukee | | LeBron James (26) | LeBron James (10) | LeBron James (8) | Quicken Loans Arena20,562 | 20–7 |- align="center" bgcolor="#ffcccc" | 28 | December 20 | @ Dallas | | LeBron James (25) | Anderson Varejão, Shaquille O'Neal (8) | LeBron James (6) | American Airlines Center20,346 | 20–8 |- align="center" bgcolor="#ccffcc" | 29 | December 21 | @ Phoenix | | LeBron James (29) | Mo Williams, LeBron James, J.J. Hickson (6) | Delonte West (6) | US Airways Center18,221 | 21–8 |- align="center" bgcolor="#ccffcc" | 30 | December 23 | @ Sacramento | | LeBron James (34) | LeBron James (16) | LeBron James (10) | ARCO Arena16,407 | 22–8 |- align="center" bgcolor="#ccffcc" | 31 | December 25 | @ L.A. Lakers | | Mo Williams (28) | Anderson Varejão, Zydrunas Ilgauskas (9) | LeBron James (9) | Staples Center18,997 | 23–8 |- align="center" bgcolor="#ccffcc" | 32 | December 27 | Houston | | LeBron James (29) | Shaquille O'Neal (11) | LeBron James (6) | Quicken Loans Arena20,562 | 24–8 |- align="center" bgcolor="#ccffcc" | 33 | December 29 | @ Atlanta | | Mo Williams (20) | LeBron James, Anderson Varejão, Shaquille O'Neal (8) | LeBron James (10) | Philips Arena20,150 | 25–8 |- align="center" bgcolor="#ccffcc" | 34 | December 30 | Atlanta | | LeBron James (48) | LeBron James (10) | Mo Williams (10) | Quicken Loans Arena20,562 | 26–8 |- align="center" bgcolor="#ccffcc" | 35 | January 2 | @ New Jersey | | LeBron James (28) | Anderson Varejão (12) | LeBron James (7) | Izod Center17,569 | 27–8 |- align="center" bgcolor="#ffcccc" | 36 | January 3 | Charlotte | | LeBron James (29) | LeBron James, Shaquille O'Neal (7) | LeBron James, Mo Williams (6) | Quicken Loans Arena20,562 | 27–9 |- align="center" bgcolor="#ccffcc" | 37 | January 6 | Washington | | LeBron James (23) | Anderson Varejão, Zydrunas Ilgauskas (8) | LeBron James (8) | Quicken Loans Arena20,562 | 28–9 |- align="center" bgcolor="#ffcccc" | 38 | January 8 | @ Denver | | LeBron James (35) | Anderson Varejão (15) | LeBron James (7) | Pepsi Center19,996 | 28–10 |- align="center" bgcolor="#ccffcc" | 39 | January