addendum also discussed the photolysis of musk xylene in water and in air, which are rapid: however, photolysis was not considered to be relevant in the persistence of musk xylene in the environment, and was not taken into account in classifying it as a "very persistent" substance. Several different primary bioaccumulation studies were reviewed in the European Union Risk Assessment Report, with bioaccumulation factors varying between 640 L/kg and 6740 L/kg. Given that musk xylene has a very high octanol–water partition coefficient (log Kow = 4.9), the higher bioaccumulation factors were considered to be the more significant. The 2008 addendum considered a further laboratory study from the Japanese Ministry of International Trade and Industry which was not available to the authors of the original Risk Assessment Report and which also showed bioaccumulation factors in fish (Cyprinus carpio) that were higher than the REACH threshold of 5000 L/kg for "very bioaccumulative" substances. Bioaccumulation factors of more than 5000 L/kg (wet weight basis) have also been found in carp (Carassius carassius) and eels (Anguilla anguilla) from a sewage treatment pond. References Further reading "ATP (2004) to the Cosmetics Directive": Commission Directive 2004/88/EC of 7 September 2004 amending Council Directive 76/768/EEC concerning cosmetic products for the purpose of adapting Annex III thereto to technical progress. OJEC L287, 8.9.2004, pp. 5–6. "ATP (2004) to the Dangerous Substances Directive": Commission Directive 2004/73/EC of 29 August 2004 adapting to technical progress for the 29th time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. OJEC L152, 30.04.2004, pp. 1–311. "CLP Regulation": Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. OJEC L353, 31.12.2008, pp. 1–1355. . .European Union Risk Assessment Report (2005). "5-tert-butyl-2,4,6-trinitro-m-xylene (musk xylene)". 3rd Priority List, Volume 55. . GHS: . . . . . . OSPAR background document. Position document prepared for the European Chemicals Bureau (9 December 2002). Classification and labelling of musk-xylene. "REACH Regulation": Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency. OJEU'' L396, 30.12.2006, pp. 1–849. . Technical report for the European Chemicals Agency.