reported in 50 to 80% of patients with primary or secondary disease treated with corticosteroid and/or immunosuppressive regimens. However, relapses occur within the first 6 months after stopping or decreasing therapy in 40 to 76% of cases. Sepsis resulting from infection of necrotic tissue is the most common threat to life in primary disease whereas the associated disorder is a critical determinant of prognosis in secondary disease. See also Cryofibrinogenemic purpura Cryoglobulinemia Dysfibrinogenemia Hypodysfibrinogenemia References Further reading External links Immune system disorders