they respond to questionnaires which results in HRQoL staying the same of even improving as their physical condition worsens. To address this issue, researchers have developed new instruments for measuring end-of-life HRQoL that incorporate factors such as sense of completion, relations with the healthcare system, preparation, symptom severity, and affective social support. Additionally, research is being conducted on the impact of existential QoL on palliative care patients as terminal illness awareness and symptom burden may be associated with lower existential QoL. Examples Similar to other psychometric assessment tools, health-related quality of life questionnaires should meet certain quality criteria, most importantly with regard to their reliability and validity. Hundreds of validated health-related quality of life questionnaires have been developed, some of which are specific to various illnesses. The questionnaires can be generalized into two categories: Generic instruments CDC HRQOL–14 "Healthy Days Measure": A questionnaire with four base questions and ten optional questions used by the Center for Disease Control and Prevention (CDC) (https://www.cdc.gov/hrqol/hrqol14_measure.htm). Short-Form Health Survey (SF-36, SF-12, SF-8): One example of a widely used questionnaire assessing physical and mental health-related quality of life. Used in clinical trials and population health assessments. Suitable for pharmacoeconomic analysis, benefiting healthcare rationing. EQ-5D a simple quality of life questionnaire (https://euroqol.org). AQoL-8D a comprehensive questionnaire that assesses HR-QoL over 8 domains - independent living, happiness, mental health, coping, relationships, self-worth, pain, senses (https://www.aqol.com.au). Disease, disorder or condition specific instruments King's Health Questionnaire (KHQ) International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) in urinary incontinence, the LC -13 Lung Cancer module from the EORTC Quality of Life questionnaire library, or the Hospital Anxiety and Depression Scale (HADS) ). Manchester Short Assessment of Quality of Life: 16-item questionnaire for use in psychiatric populations. ECOG, most commonly used to evaluate the impact of cancer on people. NYHA scale, most commonly used to evaluate the impact of heart disease on individuals. EORTC measurement system for use in clinical trials in oncology. These tools are robustly tested and validated and translated. A large amount of reference data is now available. The field of HRQOL has grown significantly in the last decade, with hundreds of new studies and better reporting of clinical trials. HRQOL appears to be prognostic for survival in some diseases and patients. WHO-Quality of life-BREF (WHOQOL-BREF): A general Quality of life survey validated for several countries. The Stroke Specific Quality Of Life scale SS-QOL: It is a patient-centered outcome