Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene. SPTBN5 belongs to the spectrin family of cytoskeletal proteins. Structure and function SPTBN5 contains the following domains: actin-binding domain membrane-association domain-1 self-association domain C-terminal pleckstrin homology domain. Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes. SPTBN5 is highly expressed in embryoid bodies. References Further reading