Dos Santos was eliminated from the competition on 1 December 2019, placing fifth. Mixed martial arts record |- |Loss |align=center|21–10 |Yorgan De Castro |TKO (shoulder injury) |Eagle FC 47 | |align=center|3 |align=center|0:35 |Miami, Florida, United States | |- |Loss |align=center|21–9 |Ciryl Gane |TKO (elbow) |UFC 256 | |align=center|2 |align=center|2:34 |Las Vegas, Nevada, United States | |- |Loss |align=center|21–8 |Jairzinho Rozenstruik |TKO (punches) |UFC 252 | |align=center|2 |align=center|3:47 |Las Vegas, Nevada, United States | |- |Loss |align=center|21–7 |Curtis Blaydes |TKO (punches) |UFC Fight Night: Blaydes vs. dos Santos | |align=center|2 |align=center|1:06 |Raleigh, North Carolina, United States | |- |Loss |align=center|21–6 |Francis Ngannou |TKO (punches) |UFC on ESPN: Ngannou vs. dos Santos | |align=center|1 |align=center|1:11 |Minneapolis, Minnesota, United States | |- |Win |align=center|21–5 |Derrick Lewis |TKO (punches) |UFC Fight Night: Lewis vs. dos Santos | |align=center|2 |align=center|1:58 |Wichita, Kansas, United States | |- |Win |align=center|20–5 |Tai Tuivasa |TKO (punches) |UFC Fight Night: dos Santos vs. Tuivasa | |align=center|2 |align=center|2:30 |Adelaide, Australia | |- |Win |align=center|19–5 |Blagoy Ivanov |Decision (unanimous) |UFC Fight Night: dos Santos vs. Ivanov | |align=center|5 |align=center|5:00 |Boise, Idaho, United States | |- |Loss |align=center|18–5 |Stipe Miocic |TKO (punches) |UFC 211 | |align=center|1 |align=center|2:22 |Dallas, Texas, United States | |- |Win |align=center|18–4 |Ben Rothwell |Decision (unanimous) |UFC Fight Night: Rothwell vs. dos Santos | |align=center|5 |align=center|5:00 |Zagreb, Croatia | |- |Loss |align=center|17–4 |Alistair Overeem |TKO (punches) |UFC on Fox: dos Anjos vs. Cowboy 2 | |align=center|2 |align=center|4:43 |Orlando, Florida, United States | |- |Win |align=center|17–3 |Stipe Miocic |Decision (unanimous) |UFC on Fox: dos Santos vs. Miocic | |align=center|5 |align=center|5:00 |Phoenix, Arizona, United States | |- |Loss |align=center|16–3 |Cain Velasquez |TKO (slam and punch) |UFC 166 | |align=center|5 |align=center|3:09 |Houston, Texas, United States | |- | Win |align=center|16–2 |Mark Hunt |KO (spinning hook kick) |UFC 160 | |align=center|3 |align=center|4:18 |Las Vegas, Nevada, United States | |- |Loss |align=center|15–2 |Cain Velasquez |Decision (unanimous) |UFC 155 | |align=center|5 |align=center|5:00 |Las Vegas, Nevada, United States | |- |Win |align=center|15–1 |Frank Mir |TKO (punches) |UFC 146 | |align=center|2 |align=center|3:04 |Las Vegas, Nevada, United States | |- |Win |align=center|14–1 |Cain Velasquez |KO (punches) |UFC on Fox: Velasquez vs. dos Santos | |align=center|1 |align=center|1:04 |Anaheim, California, United States | |- |Win |align=center|13–1 |Shane Carwin |Decision (unanimous) |UFC 131 | |align=center|3 |align=center|5:00 |Vancouver, British Columbia, Canada | |- |Win |align=center|12–1 |Roy Nelson |Decision (unanimous) |UFC 117 | |align=center|3 |align=center|5:00 |Oakland, California, United States | |- |Win |align=center|11–1 |Gabriel