via KO in the second round. A rematch against Cain Velasquez was expected on 22 September 2012 at UFC 152. However, it was later announced by Dana White that the fight would take place in Las Vegas on 29 December 2012 at UFC 155. Dos Santos lost via unanimous decision. This marked the first time Dos Santos had suffered a loss in the UFC. Dos Santos later claimed that he was training so hard prior to the bout with Velasquez that he developed rhabdomyolysis, a (sometimes fatal) breakdown of muscle fibers that releases their contents into the bloodstream, and that the condition affected his performance during the fight. Back into contention (2013–2021) Dos Santos was expected to face Alistair Overeem on 25 May 2013 at UFC 160. However, in early March, Overeem pulled out of the bout citing an injury. The bout was expected to be rescheduled for a future event, However, on 9 March, UFC President Dana White confirmed that Dos Santos's next opponent would be Mark Hunt at the same event. Dos Santos won the fight via third-round knockout. This fight earned both participants Fight of the Night award. A third fight with Cain Velasquez took place on 19 October 2013 at UFC 166. Although Dos Santos experienced more moments of success than in their second fight, he was still dominated by Velasquez for most of the fight. He lost via TKO at 3:09 of the fifth round. Dos Santos was expected to face Stipe Miocic on 24 May 2014 at UFC 173. However, the bout was delayed and was scheduled to take place a week later on 31 May 2014 at The Ultimate Fighter Brazil 3 Finale. However, on 5 May, it was announced that Dos Santos pulled out of the fight citing a hand injury and he was replaced by Fábio Maldonado. A rescheduled bout with Miocic took place as the main event at UFC on Fox 13 on 13 December 2014. Dos Santos won the back-and-forth fight via unanimous decision. The performance earned both participants Fight of the Night honors. After a year away from the sport, Dos Santos had the three-years-delayed fight with Alistair Overeem which took place on 19 December 2015 at UFC on Fox 17. He lost the bout by technical knockout in the second round. Dos Santos faced Ben Rothwell on 10 April 2016 at UFC Fight Night 86. He won