become evident, many times with the sudden eruption of multiple seborrheic keratoses, known as the sign of Leser-Trélat. Florid cutaneous papillomatosis mandates a search for an underlying malignancy, recognizing that it may be seen in patients with multiple visceral carcinomas. Histologic examination shows uniform and pronounced hyperkeratosis, acanthosis, and papillomatosis without epidermal vacuolization, parakeratosis, or eosinophilic inclusions suggestive of viral warts. The sudden quality of the eruption of florid cutaneous papillomatosis and its anatomic distribution should facilitate distinction from widespread common warts and from epidermodysplasia verruciformis. Treatment Identifying and treatment the underlying malignancy constitutes an uptime approach. Topical 5-fluorouracil may occasionally be help, as may oral retinoids, topical steroids, vitamin A acid, urea, salicylic acid, podophyllotoxin, and cryodestruction employing liquid. Prognosis Improvement usually parallels that of the cancer, whether surgical or chemotherapeutic. Generalization of the associated visceral malignancy may worsen the eruption. Epidemiology Florid cutaneous papillomatosis is almost twice as common in men than in women, and is usually diagnosed in individuals aged 53–72 years (mean patient age, 58.5 years). History Florid cutaneous papillomatosis was discovered by Robert A. Schwartz and Gordon H. Burgess. The original description was published in the Archives of Dermatology, which is published by American Medical Association. It has since been called Schwartz–Burgess syndrome. Society and culture Patients may have their unaesthetic appearance resulting in isolation from their community, feeling or being unwelcome in public places. References Bibliography External links Rare diseases Syndromes Papulosquamous hyperkeratotic cutaneous conditions