Eric Snow (6) | Gund Arena17,114 | 11–9 |- style="background:#cfc;" | 21 || December 15, 2005 || Denver | | LeBron James (26) | Donyell Marshall (12) | LeBron James (9) | Gund Arena17,182 | 12–9 |- style="background:#cfc;" | 22 || December 17, 2005 || Miami | | LeBron James (41) | Donyell Marshall (13) | LeBron James (10) | Gund Arena20,562 | 13–9 |- style="background:#cfc;" | 23 || December 20, 2005 || Utah | | LeBron James (25) | Zydrunas Ilgauskas (7) | Eric Snow (6) | Gund Arena19,543 | 14–9 |- style="background:#cfc;" | 24 || December 22, 2005 || @ Chicago | | LeBron James (37) | Zydrunas Ilgauskas (11) | LeBron James (6) | United Center21,874 | 15–9 |- style="background:#cfc;" | 25 || December 23, 2005 || Indiana | | Drew Gooden (21) | Drew Gooden (12) | LeBron James (9) | Gund Arena18,757 | 16–9 |- style="background:#cfc;" | 26 || December 26, 2005 || Chicago | | LeBron James (32) | Zydrunas Ilgauskas (14) | LeBron James, Eric Snow (6) | Gund Arena20,562 | 17–9 |- style="background:#fcc;" | 27 || December 27, 2005 || @ New Jersey | | LeBron James (31) | Donyell Marshall (14) | LeBron James (8) | Continental Airlines Arena20,098 | 17–10 |- style="background:#cfc;" | 28 || December 31, 2005 || Detroit | | LeBron James (30) | Drew Gooden (13) | LeBron James (7) | Gund Arena20,562 | 18–10 |- style="background:#cfc;" | 29 || January 4, 2006 || @ Milwaukee | | LeBron James (32) | LeBron James (11) | LeBron James (11) | Bradley Center15,785 | 19–10 |- style="background:#fcc;" | 30 || January 5, 2006 || Houston | | LeBron James (32) | Zydrunas Ilgauskas (10) | LeBron James, Eric Snow (5) | Gund Arena18,019 | 19–11 |- style="background:#cfc;" | 31 || January 7, 2006 || Milwaukee | | LeBron James (35) | Drew Gooden (17) | LeBron James (6) | Gund Arena19,840 | 20–11 |- style="background:#fcc;" | 32 || January 10, 2006 || New York | | LeBron James (36) | Drew Gooden (12) | LeBron James (7) | Gund Arena18,064 | 20–12 |- style="background:#fcc;" | 33 || January 12, 2006 || @ L.A. Lakers | | Zydrunas Ilgauskas (29) | Drew Gooden (11) | LeBron James (9) | STAPLES Center18,997 | 20–13 |- style="background:#fcc;" | 34 || January 14, 2006 || @ Phoenix | | LeBron James (46)