|| @ Minnesota | | LeBron James (35) | Donyell Marshall (13) | LeBron James (8) | Target Center17,093 | 29–19 |- style="background:#fcc;" | 49 || February 10, 2006 || @ Washington | | LeBron James (18) | LeBron James, Drew Gooden (9) | LeBron James (8) | MCI Center20,173 | 29–20 |- style="background:#fcc;" | 50 || February 11, 2006 || Golden State | | LeBron James (33) | Zydrunas Ilgauskas (8) | Damon Jones (7) | Gund Arena20,562 | 29–21 |- style="background:#cfc;" | 51 || February 13, 2006 || San Antonio | | LeBron James (44) | Zydrunas Ilgauskas (11) | Eric Snow (6) | Gund Arena19,486 | 30–21 |- style="background:#cfc;" | 52 || February 15, 2006 || @ Boston | | LeBron James (43) | LeBron James (12) | LeBron James (11) | TD Garden17,915 | 31–21 |- style="background:#cfc;" | 53 || February 21, 2006 || Orlando | | LeBron James (26) | Zydrunas Ilgauskas (13) | LeBron James (9) | Gund Arena20,562 | 32–21 |- style="background:#fcc;" | 54 || February 22, 2006 || @ Philadelphia | | LeBron James (33) | Zydrunas Ilgauskas, Drew Gooden (9) | Eric Snow (8) | Wachovia Center20,196 | 32–22 |- style="background:#fcc;" | 55 || February 24, 2006 || Washington | | LeBron James (25) | Zydrunas Ilgauskas (9) | LeBron James (9) | Gund Arena20,562 | 32–23 |- style="background:#fcc;" | 56 || February 26, 2006 || @ Detroit | | LeBron James (22) | LeBron James, Zydrunas Ilgauskas (9) | LeBron James (7) | The Palace of Auburn Hills22,076 | 32–24 |- style="background:#fcc;" | 57 || February 27, 2006 || Detroit | | LeBron James (26) | Zydrunas Ilgauskas (15) | LeBron James (6) | Gund Arena19,286 | 32–25 |- style="background:#fcc;" | 58 || March 1, 2006 || Sacramento | | LeBron James, Ronald Murray, Zydrunas Ilgauskas (19) | LeBron James (7) | LeBron James (12) | Gund Arena17,363 | 32–26 |- style="background:#cfc;" | 59 || March 2, 2006 || @ Chicago | | LeBron James (33) | LeBron James (11) | LeBron James, Eric Snow (8) | United Center20,726 | 33–26 |- style="background:#cfc;" | 60 || March 5, 2006 || Chicago | | LeBron James (37) | Anderson Varejão (13) | LeBron James, Eric Snow (7) | Gund Arena20,562 | 34–26 |- style="background:#cfc;" | 61 || March 7, 2006 || Toronto | | Ronald Murray (24) | LeBron James (12)