| Eric Snow (11) | Gund Arena18,077 | 35–26 |- style="background:#cfc;" | 62 || March 8, 2006 || @ Toronto | | LeBron James (35) | Drew Gooden, Donyell Marshall (8) | LeBron James, Eric Snow (6) | Air Canada Centre19,800 | 36–26 |- style="background:#fcc;" | 63 || March 10, 2006 || @ Orlando | | LeBron James (25) | Drew Gooden (12) | Eric Snow (5) | TD Waterhouse Centre17,283 | 36–27 |- style="background:#fcc;" | 64 || March 12, 2006 || @ Miami | | LeBron James (47) | Drew Gooden (12) | LeBron James, Eric Snow (4) | AmericanAirlines Arena20,268 | 36–28 |- style="background:#fcc;" | 65 || March 14, 2006 || @ Dallas | | LeBron James (36) | Zydrunas Ilgauskas (13) | LeBron James, Eric Snow (5) | American Airlines Center20,425 | 36–29 |- style="background:#cfc;" | 66 || March 17, 2006 || Portland | | LeBron James (27) | Drew Gooden (14) | LeBron James, Eric Snow (5) | Gund Arena20,562 | 37–29 |- style="background:#cfc;" | 67 || March 19, 2006 || L.A. Lakers | | LeBron James (29) | Drew Gooden (9) | LeBron James (7) | Gund Arena20,562 | 38–29 |- style="background:#cfc;" | 68 || March 22, 2006 || Charlotte | | LeBron James (37) | LeBron James (11) | LeBron James (12) | Gund Arena18,550 | 39–29 |- style="background:#cfc;" | 69 || March 24, 2006 || Boston | | LeBron James (36) | Zydrunas Ilgauskas (11) | LeBron James (8) | Gund Arena20,562 | 40–29 |- style="background:#cfc;" | 70 || March 26, 2006 || @ Houston | | LeBron James (36) | Zydrunas Ilgauskas, Drew Gooden (8) | Damon Jones (6) | Toyota Center16,839 | 41–29 |- style="background:#cfc;" | 71 || March 29, 2006 || Dallas | | LeBron James (46) | Zydrunas Ilgauskas (9) | Eric Snow (5) | Gund Arena19,401 | 42–29 |- style="background:#cfc;" | 72 || April 1, 2006 || Miami | | LeBron James (47) | LeBron James (12) | LeBron James (9) | Gund Arena20,562 | 43–29 |- style="background:#cfc;" | 73 || April 2, 2006 || @ Charlotte | | LeBron James (35) | LeBron James (12) | LeBron James (8) | Charlotte Bobcats Arena18,491 | 44–29 |- style="background:#cfc;" | 74 || April 4, 2006 || Philadelphia | | LeBron James (37) | Anderson Varejão (14) | LeBron James (7) | Gund Arena18,581 | 45–29 |- style="background:#fcc;" | 75