| 7 || November 13, 2005 || @ Orlando | | LeBron James (26) | Larry Hughes (9) | Larry Hughes (7) | TD Waterhouse Centre15,414 | 5–2 |- style="background:#cfc;" | 8 || November 15, 2005 || Washington | | LeBron James (37) | LeBron James (10) | Larry Hughes (8) | Gund Arena17,685 | 6–2 |- style="background:#cfc;" | 9 || November 18, 2005 || Orlando | | Zydrunas Ilgauskas (22) | Zydrunas Ilgauskas (11) | Larry Hughes (6) | Gund Arena18,591 | 7–2 |- style="background:#cfc;" | 10 || November 19, 2005 || @ Philadelphia | | Larry Hughes (37) | Drew Gooden (13) | LeBron James (10) | Wachovia Center18,908 | 8–2 |- style="background:#cfc;" | 11 || November 22, 2005 || Boston | | LeBron James (36) | Drew Gooden (15) | Eric Snow (9) | Gund Arena17,139 | 9–2 |- style="background:#fcc;" | 12 || November 24, 2005 || @ Indiana | | LeBron James (19) | LeBron James (10) | LeBron James (4) | Conseco Fieldhouse17,243 | 9–3 |- style="background:#fcc;" | 13 || November 26, 2005 || Minnesota | | LeBron James (38) | Drew Gooden (12) | Eric Snow (3) | Gund Arena20,562 | 9–4 |- style="background:#cfc;" | 14 || November 30, 2005 || L.A. Clippers | | Zydrunas Ilgauskas (29) | Zydrunas Ilgauskas (10) | LeBron James (9) | Gund Arena18,209 | 10–4 |- style="background:#fcc;" | 15 || December 2, 2005 || @ Seattle | | LeBron James (34) | Drew Gooden (7) | LeBron James (8) | KeyArena17,072 | 10–5 |- style="background:#fcc;" | 16 || December 3, 2005 || @ L.A. Clippers | | LeBron James (30) | Drew Gooden (12) | LeBron James (6) | STAPLES Center18,369 | 10–6 |- style="background:#cfc;" | 17 || December 6, 2005 || @ Sacramento | | LeBron James (30) | Drew Gooden, Zydrunas Ilgauskas (7) | LeBron James, Larry Hughes (6) | ARCO Arena17,317 | 11–6 |- style="background:#fcc;" | 18 || December 9, 2005 || New Jersey | | LeBron James (32) | Donyell Marshall (10) | Eric Snow (5) | Gund Arena18,177 | 11–7 |- style="background:#fcc;" | 19 || December 10, 2005 || @ Milwaukee | | LeBron James (52) | LeBron James, Donyell Marshall (7) | LeBron James (7) | Bradley Center18,717 | 11–8 |- style="background:#fcc;" | 20 || December 13, 2005 || Atlanta | | LeBron James (39) | Drew Gooden (11) | LeBron James,