| Zydrunas Ilgauskas (12) | LeBron James (8) | America West Arena18,422 | 20–14 |- style="background:#fcc;" | 35 || January 15, 2006 || @ Portland | | LeBron James (29) | LeBron James (13) | LeBron James (7) | Rose Garden Arena19,383 | 20–15 |- style="background:#fcc;" | 36 || January 18, 2006 || @ Denver | | LeBron James (24) | Alan Henderson (12) | LeBron James (9) | Pepsi Center19,009 | 20–16 |- style="background:#fcc;" | 37 || January 20, 2006 || @ Golden State | | Drew Gooden (16) | Zydrunas Ilgauskas (11) | LeBron James (6) | Oakland Arena20,205 | 20–17 |- style="background:#cfc;" | 38 || January 21, 2006 || @ Utah | | LeBron James (51) | Zydrunas Ilgauskas (8) | LeBron James (8) | Delta Center19,340 | 21–17 |- style="background:#cfc;" | 39 || January 24, 2006 || Indiana | | LeBron James (23) | Drew Gooden (10) | LeBron James (8) | Gund Arena19,069 | 22–17 |- style="background:#cfc;" | 40 || January 25, 2006 || @ Atlanta | | LeBron James (38) | Drew Gooden (14) | Eric Snow (8) | Philips Arena16,089 | 23–17 |- style="background:#cfc;" | 41 || January 27, 2006 || @ Indiana | | LeBron James (30) | LeBron James (7) | LeBron James (9) | Conseco Fieldhouse18,345 | 24–17 |- style="background:#cfc;" | 42 || January 29, 2006 || Phoenix | | LeBron James (44) | LeBron James (11) | LeBron James (7) | Gund Arena20,562 | 25–17 |- style="background:#cfc;" | 43 || January 30, 2006 || @ Charlotte | | LeBron James (30) | Drew Gooden (12) | Eric Snow (7) | Charlotte Bobcats Arena17,142 | 26–17 |- style="background:#cfc;" | 44 || February 1, 2006 || New Jersey | | LeBron James (26) | LeBron James (11) | LeBron James (10) | Gund Arena19,460 | 27–17 |- style="background:#fcc;" | 45 || February 2, 2006 || @ Miami | | LeBron James (29) | Zydrunas Ilgauskas, Drew Gooden (8) | LeBron James (7) | AmericanAirlines Arena20,168 | 27–18 |- style="background:#fcc;" | 46 || February 4, 2006 || Philadelphia | | LeBron James (31) | Zydrunas Ilgauskas (11) | LeBron James (6) | Gund Arena20,562 | 27–19 |- style="background:#cfc;" | 47 || February 6, 2006 || Milwaukee | | LeBron James (22) | LeBron James (9) | LeBron James (12) | Gund Arena19,126 | 28–19 |- style="background:#cfc;" | 48 || February 8, 2006