Pettitte || Hancock || Lidge || 44,732 || 33–19 |- style="background-color:#bbffbb" | 53 || May 31 || Astros || 4–3(11) || Looper || Gallo || || 43,534 || 34–19 |- style="background-color:#ffbbbb" | 54 || June 2 || Cubs || 4–5(14) || Dempster || Hancock || || 45,799 || 34–20 |- style="background-color:#ffbbbb" | 55 || June 3 || Cubs|| 5–8 || Rusch || Mulder || Howry || 45,820 || 34–21 |- style="background-color:#bbffbb" | 56 || June 4 || Cubs|| 9–6 || Marquis || Maddux || Isringhausen || 45,753 || 35–21 |- style="background-color:#ffbbbb" | 57 || June 5 || Reds || 7–8 || Yan || Isringhausen || Coffey || 43,707 || 35–22 |- style="background-color:#ffbbbb" | 58 || June 6 || Reds || 0–7 || Milton || Carpenter || || 43,857 || 35–23 |- style="background-color:#ffbbbb" | 59 || June 7 || Reds || 4–7 || Harang || Ponson || Coffey || 44,306 || 35–24 |- style="background-color:#bbffbb" | 60 || June 9 || @ Brewers || 10–6 || Hancock || Winkelsas || Isringhausen || 24,490 || 36–24 |- style="background-color:#ffbbbb" | 61 || June 10 ||@ Brewers || 3–4 || Wise || Flores || Turnbow || 36,981 || 36–25 |- style="background-color:#bbffbb" | 62 || June 11 || @ Brewers || 7–5 || Hancock || Bush || Isringhausen || 29,122 || 37–25 |- style="background-color:#bbffbb" | 63 || June 13 || @ Pirates || 2–1 || Carpenter || Ol. Perez|| Isringhausen || 24,443 || 38–25 |- style="background-color:#ffbbbb" | 64 || June 14 || @ Pirates || 7–9 || Duke || Ponson || Gonzalez || 20,289 || 38–26 |- style="background-color:#bbffbb" | 65 || June 15 || @ Pirates || 6–5 || Mulder || Santos || Isringhausen || 18,248 || 39–26 |- style="background-color:#bbffbb" | 66 || June 16 || Rockies || 8–1 || Marquis || Cook || || 45,736 || 40–26 |- style="background-color:#bbffbb" | 67 || June 17 || Rockies || 6–5 || Suppan || Francis || Isringhausen || 45,968 || 41–26 |- style="background-color:#bbffbb" | 68 || June 18 || Rockies || 4–1 || Carpenter || Fogg || Isringhausen || 45,647 || 42–26 |- style="background-color:#ffbbbb" | 69 || June 20 || @ White Sox || 6–20 || Vazquez || Mulder || || 39,463 || 42–27 |- style="background-color:#ffbbbb" | 70 || June 21 || @ White Sox || 5–13 || Buehrle || Marqus || || 37,897 || 42–28 |- style="background-color:#ffbbbb" | 71 || June 22 || @ White Sox ||