in the ratio of TxA2/PGI2 could lead to increased platelet aggregation and dysregulation of platelet homeostasis. The GI and renal systems of patients who are treated with NSAIDS for a long period of time may experience unwanted side effects compared to patients who are treated for shorter durations. Studies on NSAIDS have shown that it can cause acute kidney injury by inhibiting prostaglandin production. The decreased levels of prostaglandins increases the risks of interstitial nephritis since there is lower blood flow to the kidneys. However, the risks of NSAIDs induced kidney failure is higher in people with diabetes or cardiovascular disease. A study on grapiprant showed that it negatively impacted the GI system, but the response was mild enough for the owners to not seek medical attention or removal from the trial. In contrast, prolonged use of NSAIDs has shown to increase the risk of toxicity of multiple organs like the GI tract, kidneys, and liver. See also Mechanism of action of aspirin References External links Receptor antagonists Prostaglandins