experience in interaction research. LTP curators are given further training through the Canadian Bioinformatics Workshops. Information on small molecule chemistry is curated separately by chemists to ensure the curator is knowledgeable about the subject. The priority for BIND curation is to focus on LTP to collect information as it is published. Although, HTP studies provide more information at once, there are more LTP studies being reported and similar numbers of interactions are being reported by both tracks. In 2004, BIND collected data from 110 journals. Database growth BIND has grown significantly since its conception; in fact, the database saw a 10 fold increase in entries between 2003 and 2004. By September 2004, there were over 100,000 interaction records by 2004 (including 58,266 protein-protein, 4,225 genetic, 874 protein-small molecule, 25,857 protein-DNA, and 19,348 biopolymer interactions). The database also contains sequence information for 31,972 proteins, 4560 DNA samples and 759 RNA samples. These entries have been collected from 11,649 publications; therefore, the database represents an important amalgamation of data. The organisms with entries in the database include: Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Mus musculus, Caenorhabditis elegans, Helicobacter pylori, Bos taurus, HIV-1, Gallus gallus, Arabidopsis thaliana, as well as others. In total, 901 taxa were included by September 2004 and BIND has been split up into BIND-Metazoa, BIND-Fungi, and BIND-Taxroot. Not only is the information contained within the database continually updated, the software itself has gone through several revisions. Version 1.0 of BIND was released in 1999 and based on user feedback it was modified to include additional detail on experimental conditions required for binding and a hierarchical description of cellular location of the interaction. Version 2.0 was released in 2001 and included the capability to link to information available in other databases. Version 3.0 (2002) expanded the database from physical/biochemical interactions to also include genetic interactions. Version 3.5 (2004) included a refined user-interface that aimed to simplify information retrieval. In 2006, BIND was incorporated into the Biomolecular Object Network Database (BOND) where it continues to be updated and improved. Special features BIND was the first database of its kind to contain info on biomolecular interactions, reactions and pathways in one schema. It is also the first to base its ontology on chemistry which allows 3D representation of molecular interactions. The underlying chemistry allows molecular interactions to be described down to the atomic level of resolution. PreBIND an associated system for data