the Leading Role category in 2006. She acted in the much acclaimed Bengali film Ek Mutho Chabi (2005), produced by herself, where she played the character of an established actress who has a car accident, consequently losing her career. In December 2005, Ganguly was named by The Telegraph in the list of Five Crowning Queens of 2005 alongside Rani Mukerji, Preity Zinta, Konkona Sen Sharma and Vidya Balan. In 2006, she accepted a role of a writer in Karam Apnaa Apnaa produced by Balaji Telefilms and shifted her base to Mumbai. She then appeared in Hindi TV series such as Love Story and Agle Janam Mohe Bitiya Hi Kijo (2009). In 2009, she appeared in Sekhar Das's Bengali film Kaaler Rakhal. She appeared in Anjan Dutt's film Chowrasta the Crossroads of love (2009). In 2011, she won the National Film Award for Best Female Playback Singer for rendering her voice in Aditi Roy's Bengali film Abosheshey (2012) where she also acted. In the film, she portrayed the character of Suchismita. She appeared in Birsa Dasgupta's Jaani Dyakha Hawbe (2011), which after much commercial expectation proved to be a failure at the box office. She acted in Anurag Basu's blockbuster film Barfi! (2012). She acted in Anjan Dutt's Dutta Vs Dutta, (2012) where she played the character of "Runu mashi", who lives her life on her own terms and inspires the protagonist to live the life he desires. She featured in Joydeep Ghosh's Mayabazar (2012). The film has three individual stories. She played the protagonist in the story Smriti which is based on Dehantar by Sharadindu Bandopadhyay. She played Kuhu, a widow who sees her deceased husband in every single man she dates. She appeared in Riingo's Bengali film Na Hannyate (2012), where she played the character of Jui, who is caught in a situation where she could save only one of her kids and leave the other to die. In 2013, she appeared in Utsav Mukherjee's hilarious social-satirical film Half Serious. She played the role of goddess Durga in the film. She appeared in Rana Basu's Bengali film Namte Namte (2013). She also appeared in Shekhar Das's Bengali film Nayanchampar Dinratri (2013). In 2014, she appeared alongside Soumitra Chatterjee in Souvik Mitra's Bengali film Punascha, where she played the muse of an award-winning author, played by Chatterjee. The film earned her rave reviews including the statement made by The Times