number of NKB neurons in the arcuate nucleus. Along with rats, primate studies have been done, investigating the effects of NKB and the other peptides of the KNDy subpopulation. Due to the similarity in brain structure monkeys have been good research candidates. In humans, as previously mentioned, NKB signaling plays a vital role in hormone secretion, especially that of luteinizing hormone before the onset of puberty. It was shown, in monkeys, that activation of NK3R, the NKB receptor, was associated with release of hormones that come before the onset of puberty. This included initial release of GnRH. NKB found mostly in the arcuate nucleus in humans, is found mostly in the monkey hypothalamus. By injecting NKB analogs pulsatile GnRH was secreted, activating the hypothalmic-pituitary axis and therefore releasing LH. Researchers found these results consistent across both monkey and human brains. References Neuropeptides