tissue in terms of differentiation of osteoclasts and osteoblasts. Overactivation of osteoclasts as well as accumulation of other immune cells has been linked to Osteoporosis. CX3CR1 with Fractalkine have a meaningful place also in many various types of cancer (e.g. Neuroblastoma, Prostate cancer, Gastric adenocarcinoma or B cell lymphomas) where CX3CL1-CX3CR1 axis is a double agent, providing antitumoral effects (stimulating and recruiting immune cells to target neoplasm) and protumoral effects (stimulating important activity in malignant cells like: invasion, proliferation and apoptosis resistance, for facilitating metastasis). Therefore, it has a lot of potential as therapeutical target in cancer. References Further reading External links Cytokines Cell biology Receptors Integral membrane proteins