Angelo Maria Maffucci (October 27, 1847 – November 24, 1903) was an Italian pathologist of the nineteenth century. His most important scientific contribution is related to the description of the disease known as Maffucci’s Syndrome. Maffucci was a pioneer in the field of embryonal infective pathology. His settlement in Pisa, as the chairman of Pathology, represents a very significant moment for the Pisan academic environment and for the University of Pisa. Biography Early life and education Angelo Maria Maffucci was an Italian pathologist born in the town of Calitri in the province of Avellino on October 27, 1847, from a family of farmers, son of Michele and Benedetta Nicolais. His parents, who at first wanted him to continue the traditional family business, to then embrace the ecclesiastical career, were disappointed when after completing his secondary studies, Maffucci enrolled in the degree course in Medicine and Surgery at the University of Naples from which he graduated in 1872. After graduating, Maffucci was active in the campaign against cholera as medical officer and as surgeon at the Hospital of Santa Maria del Popolo (Ospedale degli Incurabili). His commitment in the cause earned him a medal in 1873. His first approaches with pathological anatomy were realized in the renowned Neapolitan School of Otto von Schrön(1837-1917), he worked as a surgeon at the Ospedale degli Incurabili in Naples and as a vaccinating physician at the Town Hall of the same city. Professional career In 1880, he won a competition for the chair of General Pathology at the University of Messina, however the university didn't allow funding for his research due to the skepticality on his project, which led him to renounce his position. In 1884 he occupied the Chair of Pathological Anatomy at the University of Catania, he abandoned his position briefly after when he was offered a position at the University of Pisa where he remained until his death. Of his prolific activity remain numerous manuscripts, prints, drawings and watercolours illustrations, with meticulous precision, the observations made in many years of medical practice, today conserved in the library of History of Medicine of the University La Sapienza of Rome. Maffucci was a member of numerous academies and scientific societies, including the Accademia Nazionale dei Lincei, and he received from the Venetian Institute of Sciences, Letters and Arts a prize for the progress in Medical Sciences. Later life He retired to Vallombrosa, near Florence,