one mutation. Weale et al. state that the discovery of DE* among Nigerians pushes back the date for the most recent common ancestor (MRCA) of African YAP chromosomes. This, in his view, has the effect of reducing the time window through which a possible back migration from Asia to Africa could occur. Chandrasekhar et al. 2007, have argued for an Asian origin of the YAP+. They state: "The presence of the YAP insertion in Northeast Indian tribes and Andaman Islanders with haplogroup D suggests that some of the M168 chromosomes gave rise to the YAP insertion and M174 mutation in South Asia." They also argue that YAP+ migrated back to Africa with other Eurasian haplogroups, such as Haplogroup R1b1* (18-23kya), which has been observed with especially high frequency among the members of some peoples in northern Cameroon, and Haplogroup T (39-45 kya), which has been observed in low frequencies in Africa. Haplogroup E at 50kya is considerably older than these haplogroups and has been observed at frequencies of 80-92% in Africa. In a 2007 study, Peter Underhill and Toomas Kivisild stated that there will always be uncertainty regarding the precise origins of DNA sequence variants such as YAP because of a lack of knowledge concerning prehistoric demographics and population movements. However Underhill and Kivisild contend that with all the available information, the African origin of the YAP+ polymorphism is more parsimonious and more plausible than the Asian origin hypothesis. In a press release concerning a study by Karafet et al. 2008, Michael Hammer revised the dates for the origin Haplogroup DE from 55,000 years ago to 65,000 years ago. For haplogroup E, Hammer revised the dates from 31,000 years ago to 50,000 years ago. Hammer is also quoted as saying “The age of haplogroup DE is about 65,000 years, just a bit younger than the other major lineage to leave Africa, which is assumed to be about 70,000 years old”, in which he implies that haplogroup DE left Africa soon after haplogroup CT. A 2018 study, based on analyzing maternal and paternal markers, their current distribution, and inferences from the DNA of the Altai Neanderthals, argues for an Asian origin of paternal haplogroup DE and maternal haplogroup L3. The study suggests a back migration into Africa and a following admixture of the native Africans with immigrating peoples from Asia. It is suggested that DE originated about 70,000 years ago somewhere