up to the Barnadi river by defeating Harup Narayan who was a descendant of Gandharva-raya, a Bhuyan from the second group established by Durlabhnarayana at Bausi (Chota raja of Bausi), among others. The Baro-Bhuyans retaliated and were instrumental in ending the rule of Alauddin Husain Shah via his son Shahzada Danyal. But very soon, the rise of Biswa Singha of the Koch dynasty in Kamata destroyed their hold in Kamrup and squeezed those in the Nagaon region against the Kacharis to their east. They had to relocate to the north bank of the Brahmaputra in the first quarter of the 16th century, to a region west of the Bor Baro-Bhuyan group. The increasing Koch and Ahom conflicts further ate away at their independence and sovereignty. Baro-Bhuiyans of Bengal At the end of the Karrani Dynasty (1564–1575), the nobles of Bengal became fiercely independent. Sulaiman Khan Karrani carved out an independent principality in the Bhati region comprising a part of greater Dhaka district and parts of Mymensingh district. During that period Taj Khan Karrani and another Afghan chieftain helped Isa Khan to obtain an estate in Sonargaon and Mymensingh in 1564. By winning the grace of the Afghan chieftain, Isa Khan gradually increased his strength and status and by 1571, the Mughal Court designated him as the ruler of Bhati. Bhati region Mughal histories, mainly the Akbarnama, the Ain-i-Akbari and the Baharistan-i-Ghaibi refers to the low-lying regions of Bengal as Bhati. This region includes the Bhagirathi to the Meghna River is Bhati, while others include Hijli, Jessore, Chandradwip and Barisal Division in Bhati. Keeping in view the theatre of warfare between the Baro-Bhuiyans and the Mughals, the Baharistan-i-Ghaibi mentions the limits of the area bounded by the Ichamati River in the west, the Ganges in the south, the Tripura to the east; Alapsingh pargana (in present Mymensingh District) and Baniachang (in greater Sylhet) in the north. The Baro-Bhuiyans rose to power in this region and put up resistance to the Mughals, until Islam Khan Chisti made them submit in the reign of Jahangir. Isa Khan Isa Khan was the leader of the Baro Bhuiyans (twelve landlords) and a zamindar of the Bhati region in medieval Bengal. Throughout his reign he put resistance against Mughal invasion. It was only after his death, when the region went totally under Mughals. The Jesuit mission who sent to Bengal managed to identify that 3 of