División. He took the team from 17th to promotion as runners-up to Atlético, but left at the end of the season due to pressure and handed the reins to his former teammate Manuel Preciado. For the 2003–04 campaign, Setién returned to the second division with Polideportivo Ejido. He was dismissed on 17 November, with the team in the relegation zone. In 2005, Setién was appointed assistant coach to the Russia national beach soccer team. For three months during the following year, he was in charge of Equatorial Guinea. After that he moved to another team he played for, Logroñes in division three, being relieved of his duties midway through the 2007–08 campaign. Lugo In June 2009, Setién became CD Lugo's coach. He led the side to promotion to the second tier in his third year, a second-ever for the Galicians. In the following three years they managed to stay afloat, ranking between positions 11th and 15th. Las Palmas On 19 October 2015, following the dismissal of Paco Herrera, Setién became the new manager of UD Las Palmas in the top flight. He arrived with them in the relegation zone, and led them to 11th place in his first season. On 18 March 2017, Setién announced that he would leave the Canary Islands club at the end of the campaign due to disputes with the board. Betis On 26 May 2017, Setién was appointed manager of Real Betis on a three-year deal. He led the team to the sixth place in his first year, with the subsequent qualification to the group stage of the UEFA Europa League. Setién was linked with a move to FC Barcelona in January 2019, but it did not materialise. On 19 May, he announced that he would leave the Estadio Benito Villamarín. Barcelona Setién signed as head coach of Barcelona on 13 January 2020, replacing the dismissed Ernesto Valverde on a contract lasting to June 2022. In his first match in charge, six days later, he managed a 1–0 home victory over Granada CF. The team eventually finished the domestic league in second position, behind Real Madrid. On 14 August 2020, they lost 8–2 to FC Bayern Munich in the quarter-finals of the UEFA Champions League, which was the first time in 74 years that the club had conceded eight goals in a game; it was also the first loss by a six-goal margin since 1951.