Martin and D-Wave collaboration On May 25, 2011, Lockheed Martin signed a multi-year contract with D-Wave Systems to realize the benefits based upon a quantum annealing processor applied to some of Lockheed's most challenging computation problems. The contract included purchase of the D-Wave One quantum computer, maintenance, and associated professional services. Optimization problem-solving in protein structure determination In August 2012, a team of Harvard University researchers presented results of the largest protein-folding problem solved to date using a quantum computer. The researchers solved instances of a lattice protein folding model, known as the Miyazawa–Jernigan model, on a D-Wave One quantum computer. D-Wave Two In early 2012, D-Wave Systems revealed a 512-qubit quantum computer, code-named Vesuvius, which was launched as a production processor in 2013. In May 2013, Catherine McGeoch, a consultant for D-Wave, published the first comparison of the technology against regular top-end desktop computers running an optimization algorithm. Using a configuration with 439 qubits, the system performed 3,600 times as fast as CPLEX, the best algorithm on the conventional machine, solving problems with 100 or more variables in half a second compared with half an hour. The results are presented at the Computing Frontiers 2013 conference. In March 2013 several groups of researchers at the Adiabatic Quantum Computing workshop at the Institute of Physics in London produced evidence, though only indirect, of quantum entanglement in the D-Wave chips. In May 2013 it was announced that a collaboration between NASA, Google and the USRA launched a Quantum Artificial Intelligence Lab at the NASA Advanced Supercomputing Division at Ames Research Center in California, using a 512-qubit D-Wave Two that would be used for research into machine learning, among other fields of study. D-Wave 2X and D-Wave 2000Q On August 20, 2015, D-Wave released general availability of their D-Wave 2X computer, with 1000 qubits in a Chimera graph architecture (although, due to magnetic offsets and manufacturing variability inherent in the superconductor circuit fabrication, fewer than 1152 qubits are functional and available for use; the exact number of qubits yielded will vary with each specific processor manufactured). This was accompanied by a report comparing speeds with high-end single threaded CPUs. Unlike previous reports, this one explicitly stated that question of quantum speedup was not something they were trying to address, and focused on constant-factor performance gains over classical hardware. For general-purpose problems, a speedup of 15x was reported, but it is worth noting