Bloomberg and Carlyle Group co-founder David Rubenstein to put together a $25 million donation to support research for finding a cure to Amyotrophic lateral sclerosis (ALS). Doctoroff's father died of ALS in 2002, and his uncle Michael died of ALS in 2010. In 2013, Doctoroff became President and Chairman of a non-profit organization created to build a new arts facility at Hudson Yards, originally known as Culture Shed. During his term as Deputy Mayor, Doctoroff led the process of site preservation for The Shed as part of the redevelopment of Manhattan's Far West Side. Doctoroff also led efforts to raise $636 million for the Shed's construction and launch, oversaw the construction of the building and led the search to recruit Alex Poots as the Shed's first CEO and artistic director. The Shed opened in 2019. In 2013, Doctoroff founded Target ALS, a medical research foundation, with Bloomberg Philanthropies and David Rubenstein, following the death of Doctoroff's father and uncle from Amyotrophic Lateral Sclerosis. He donated $10 million of his personal wealth to the foundation. Target ALS has funded Cambridge biotech Biogen's clinical trials of an experimental drug purchased from Karyopharm Therapeutics in 2018. In late 2021, Doctoroff announced his own diagnosis with ALS, stating that he would "dedicate my life to battling this disease," beginning with a new $250 million fundraising effort. Doctoroff is a member of the board of directors of Bloomberg Philanthropies and is both founder and chair of the board of Target ALS. Doctoroff is chairman and President of the board of directors of The Shed, the arts facility at the Hudson Yards development in New York City. In March 2015, Doctoroff was appointed to the United States Olympic Committee board of directors. In September 2017, Doctoroff's book Greater Than Ever: New York's Big Comeback, was published by PublicAffairs/Hachette Book Group. Doctoroff was a member of the advisory board for Neom, Saudi Arabia's plan to build a futuristic "mega city" in the desert. Personal life After meeting at Harvard during their first year, Doctoroff married Alisa Robbins in 1981. He is Jewish, and in 2013 Alisa Robbins Doctoroff was appointed the president of the UJA-Federation of New York; previously she served as president of Congregation Or Zarua in Manhattan. The couple has three children and resides in New York City. Doctoroff is a second cousin of New York Times domestic correspondent Katherine Rosman. His grandmother, Jennie Miller