U.S. Highway 52 (US 52) is a United States Numbered Highway in northeast Iowa. The route begins at the Dale Gardner Veterans Memorial Bridge over the Mississippi River between Sabula and Savanna, Illinois. From Sabula, it heads north along the Mississippi towards Bellevue and Dubuque. At Dubuque, US 52 briefly shares an expressway with US 61 and US 151 before joining the Southwest Arterial, another expressway diverting traffic around the southern edge of Dubuque. West of Dubuque, the route concurrently follows the US 20 expressway before joining Iowa Highway 136 (Iowa 136) in Dyersville. At Luxemburg, it continues north towards Guttenberg. It then heads northwest where it overlaps US 18 for . At Calmar, US 52 turns to the north towards Decorah. US 52 crosses into Minnesota north of Burr Oak. Despite its even number, US 52 is signed as a north–south route. According to the layout of the U.S. Highway System, even-numbered routes are generally signed as east–west routes. Route description US 52 begins in Iowa with Iowa 64 on the Dale Gardner Veterans Memorial Bridge over the Mississippi River north of Sabula. After descending the bridge, the two routes turn to the south and travel along a narrow, causeway through the Mississippi backwaters. The two routes pass through Sabula, a city known as Iowa's island city, and turn west crossing another causeway to the mainland. Upon rising from the river valley, US 52/Iowa 64 meets the northern end of US 67. Iowa 64 continues west with US 67, while US 52 turns north to follow the river. Between Sabula and Bellevue, US 52 follows the course of the Mississippi River. The roadway gradually enters the Driftless Area, a region of the midwestern United States which escaped glaciation during the last glacial period. Near the unincorporated community of Green Island, the highway passes through terrain where the elevation ranges from above sea level. North of Green Island, where it crosses the Maquoketa River, US 52 follows the bluffs along the Mississippi River valley. The Canadian Pacific Railway, which runs parallel to US 52 between Green Island and Bellevue, in locations, lies below the road as the roadway follows the bluffs while the railroad tracks stay in the flat valley. At Bellevue, US 52 runs along the city's riverfront and passes Lock and Dam No. 12, intersecting with the eastern terminus of Iowa 62. North of Bellevue, it turns to