between bivalency and cancer which could drive biomedical research in disease etiology and treatment. The information of a one gene should be the different in executive way in the cell types to achieve main program in this diversity. Chromatin is carrier of the instructions and also the DNA surrounded by the histones shows impact of the nucleosome which we can see this is the basic unit. The packed gives information for regulation nucleosome of physical barrier they show impact on the chromatin remodelers parts N- terminal parts of histone particle, histone tails, covalent post-translational modifies and also creates an epigenetics of [PCG] and [TRXG] plays an initial role these mutations caused in groups from transformation in Drosophila shows a clearcut information Structure A bivalent is the association of two replicated homologous chromosomes having exchanged DNA strand in at least one site called chiasmata. Each bivalent contains a minimum of one chiasma and rarely more than three. This limited number (much lower than the number of initiated DNA breaks) is due to crossover interference, a poorly understood phenomenon that limits the number of resolution of repair events into crossover in the vicinity of another pre-existing crossover outcome, thereby limiting the total number of crossovers per homologs pair. A bivalent is the association of two replicated homologous chromosomes having exchanged DNA strand in at least one site called chiasmata. Each bivalent contains a minimum of one chiasma and rarely more than three. This limited number (much lower than the number of initiated DNA breaks) is due to crossover interference, a poorly understood phenomenon that limits the number of resolutions of repair events into crossover in the vicinity of another pre-existing crossover outcome, thereby limiting the total number of crossovers per homologs pair. Bivalent gene is a gene marked with both H3K4me3 and H3K27me3 epigenetic modification in the same area of this kind and is proposed to play a pivotal role related to pluripotency in embryonic stem (ES) cells. Bivalent promoters marked with both H3K27me3 and H3K4me3 histone modifications are characteristic of poised promoters in embryonic stem (ES) cells. The model of poised promoters postulates that bivalent chromatin in ES cells is resolved to Mono valency upon differentiation. With the availability of single-cell RNA sequencing (scRNA-seq) data, subsequent switches in transcriptional state at bivalent promoters can be studied more closely. Function At the meiotic metaphase I, the cytoskeleton puts the bivalents under tension