losartan is not halting the growth of the aorta, irbesartan has been shown to work and is currently also being studied and prescribed for some patients with this condition. If an increased heart rate is present, a cardioselective beta-1 blocker, with or without losartan, is sometimes prescribed to reduce the heart rate to prevent any extra pressure on the tissue of the aorta. Likewise, strenuous physical activity is discouraged in patients, especially weight lifting and contact sports. Epidemiology The incidence of Loeys–Dietz syndrome is unknown; however, Type 1 and 2 appear to be the most common. References Further reading External links orphan.net LDS-Syndrome Vascular diseases Cell surface receptor deficiencies Abnormalities of dermal fibrous and elastic tissue Rare diseases Syndromes affecting the aorta