Barbara Mary Frances Pearse FRS (born 24 March 1948, Wraysbury, Buckinghamshire, England) is a British biological scientist. She works at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom. Education Barbara Pearse attended the independent Lady Eleanor Holles School in Hampton in Greater London, and gained her undergraduate degree from University College London in 1969. Career She was appointed to the scientific staff of the MRC Laboratory of Molecular Biology in 1982. Research Pearse's main contributions lie in the structure of coated vesicles. Pearse first purified coated vesicles; she also discovered the clathrin coat molecule in 1975. Coated pits and vesicles were first seen in thin sections of tissue in the electron microscope by Thomas Roth and Keith Porter in 1964. The importance of them for the clearance of LDL from blood was discovered by R. G. Anderson, Michael S. Brown and Joseph L. Goldstein in 1976. Awards and honours She was visiting professor in cell biology at Stanford University (1984-5). She was elected a member of European Molecular Biology Organization (EMBO) in 1982 and awarded the EMBO Gold Medal in 1987. She was elected a Fellow of the Royal Society in 1988. Personal life She is married to Mark Bretscher, another scientist. References 1948 births 20th-century British biologists 20th-century British women scientists 21st-century British biologists 21st-century British women scientists Academics of the University of Cambridge Academics of University College London Alumni of University College London British women biologists Fellows of the Royal Society Female Fellows of the Royal Society Living people Members of the European Molecular Biology Organization People educated at Lady Eleanor Holles School People from Buckinghamshire People from the Royal Borough of Windsor and Maidenhead Stanford University faculty