Navigation and turns down Main Street, exiting the city as U.S. Route 90 Alternate. On the way, it passes Rice University, University of Houston, and the Astrodome. "Old Spanish Trail" is the official name for the street that follows the route from Interstate 45 south of downtown Houston until it merges with South Main Street in the Texas Medical Center. At Eagle Lake, the trail heads Northwest along FM102, a pre-1958 alignment of U.S. 90A, where it rejoins present day U.S. 90 in Alleyton. At Waelder, the trail again departs U.S. 90, heading down Texas State Highway 97 into Gonzales and heading along U.S. 90A into Seguin. At Seguin, the OST heads towards San Antonio along a road at various points signed Seguin Road, FM78, San Antonio Street, and John E Peterson Boulevard. In San Antonio, the OST once traveled along Seguin Road directly to New Braunfels Avenue, turning south towards Houston Street, then West along Houston Street into town. Today, a portion of the Seguin Road grade is buried under I-35. San Antonio contains several reminders of the Old Spanish Trail's existence. On the grounds of City Hall can be found a Zero Milestone marker dedicated by Governor Pat Neff on March 27, 1924. The OST headquarters once resided within the Gunter Hotel, now called the Sheraton Gunter Hotel. At the corner of Fredericksburg, which carries the trail out of town westward, and Vance Jackson Road, a marker of the Old Spanish Trail placed by the Daughters of the Republic of Texas in 1936 still stands. A few blocks Northwest of the marker lies a park named 'Old Spanish Walking Trails'. The trail continues North along Fredericksburg where it joins U.S. Highway 87 and I-10. At Leon Springs, The Old Spanish Trail departs the highway and travels North along Boerne Stage Road. At the Bexar-Kendall County line, the remains of a stone county line OST marker can be seen on the Eastern side, just north of the bridge over Balcones Creek. An alternate 'Tourist Route' leaves San Antonio along Bandera Road, signed SH-16. Bandera is home to the O.S.T. Restaurant, which has served travelers of the Old Spanish Trail since 1921. Outside Bandera, the trail continues north along SH-173 where it rejoins the main portion of the trail in Kerrville. A portion of the trail remains as a segment of U.S. Route 290 west of Ozona, Texas in Crockett