in the Bills Toronto Series featured the host Bills defeating the Indianapolis Colts in Toronto on Thursday, August 19 by a score of 34–21. Exact dates and times for most games were announced in April, shortly after the regular season games were announced. Regular season The 2010 regular season was the first year that the league used a modified version of the scheduling formula that was first introduced in , in which all teams play each other at least once every four years, and play in every other team's stadium at least once every eight years (notwithstanding the regular season games played overseas as part of the NFL International Series). Under the original 2002 formula, since the pairings were strictly based on alphabetical order, those teams scheduled to play the entire AFC West had to travel to both Oakland and San Diego in the same season, while those teams playing the entire NFC West had to make their way to both San Francisco and Seattle. In , the New England and New York Jets each had to make cross-country trips to all four of the aforementioned West Coast teams. In an effort to relieve east coast teams from having to travel to the West Coast multiple times during the same season, teams will only have to visit one West Coast team (AFC West or NFC West), plus one western team from the same division closer to the Midwest, under the 2010 modified formula. Specifically, those teams traveling to Oakland (Las Vegas since 2020) will also play at Denver, while those playing at San Diego (Los Angeles since 2017) will also play at Kansas City. For teams scheduled to play the NFC West, those traveling to San Francisco will also go to Arizona, while those scheduled to play in Seattle will then go to St. Louis (this became moot in 2016 when the Rams returned to Los Angeles). For the 2010 season, the intraconference and interconference matchups are: Intraconference AFC East vs. AFC North AFC West vs. AFC South NFC East vs. NFC North NFC West vs. NFC South Interconference AFC East vs. NFC North AFC West vs. NFC West AFC North vs. NFC South AFC South vs. NFC East The entire 2010 regular-season schedule was unveiled at 7:00 pm EDT on Tuesday, April 20. Additionally, schedule release shows aired on both the NFL Network and as a SportsCenter special on