The song is the band's first to achieve significant popularity outside of the United States. "How to Save a Life" was a top five hit in Australia, Canada, Ireland, Italy, Spain, Sweden and the United Kingdom. Due to an early leak by BBC Radio 1 in the United Kingdom, where it was the band's debut single, the song was released in the territory five weeks earlier than planned. It debuted at number 29 on the UK Singles Chart on January 21, 2007, via downloads alone. Instead of its planned release date which was to be March 26, 2007, the single was physically released in the United Kingdom on February 28 and gradually rose up the chart, reaching number five on February 25, staying there for four weeks. It eventually peaked at number four on the UK Singles Chart on April 8 and became Britain's eleventh biggest-selling song of 2007. On March 29, "How to Save a Life" peaked at number 1 in Ireland, becoming their first and only number one single in the country to date. The song only stayed at the top spot for a week but sales still proved strong after it fell from number 1. The song was ranked No. 24 on Billboards Best Adult Pop Songs of the Decade, and No. 47 on Billboard's Top 100 Digital Tracks of the Decade. It was also ranked No. 58 on Billboard's Hot 100 Songs of the Decade and No. 56 on Rhapsody's list of the Top 100 Tracks of the Decade. The song was the 25th most downloaded song of all time on iTunes as of February 2010. The song has sold over 4.7 million copies in the US as of January 2015. In popular culture The song was first featured on ABC's Grey's Anatomy, after Alexandra Patsavas, the music supervisor for the show, saw the band perform in Los Angeles. Alexandra then incorporated the song into the second-season episode "Superstition". After its usage in the episode, the song became a minor Hot 100 hit. The song became an "unofficial theme" for the other members of the Grey's Anatomy production after the episode aired, leading to the decision that the song would be used in the main promotion for the third season in the show. Grey's Anatomy is credited with bringing popularity to the song. It was also used in the show's musical episode when Callie was having