for Best Actress (Television) for her performance. Her theatre work includes roles in Duck, Titus Andronicus and Lay Me Down Softly. As of 2007, she began working with the Irish theatrical group Pan Pan Theatre. In 2010, she played Ophelia in the National Theatre's production of Hamlet. She also provided voice acting in the video game Dark Souls II, playing Shanalotte, otherwise known as "the Emerald Herald". In 2013, it was announced that Negga had been booked for a recurring role as Raina on the American TV series Agents of S.H.I.E.L.D. She appeared in 17 episodes of the programme. She filmed scenes for Steve McQueen's Oscar-winning 12 Years a Slave, but her role was ultimately cut from the movie. In March 2015, Negga was cast in the role of Tulip O'Hare in AMC fantasy drama series Preacher, which debuted the following year. In 2016, Negga portrayed Mildred Loving in the Jeff Nichols historical romance Loving, which premiered at the 2016 Cannes Film Festival and later screened at the Toronto International Film Festival. The film is based on the true story of the Lovings, a married interracial couple in the 1950s and 1960s Virginia, whose relationship led to the Supreme Court decision Loving v. Virginia. Negga received rave reviews for the role, and garnered multiple award nominations, including for the Academy Award for Best Actress, the Golden Globe Award for Best Actress in a Motion Picture – Drama, and the BAFTA Rising Star Award. Negga played Prince Hamlet in the Gate Theatre's 2018 production (directed by Yaël Farber) of Hamlet (Having a woman play the role of Prince Hamlet although depicted as a man in the play is a precedent established in Dublin by Fanny Furnival in 1741). Negga reprised the role of Hamlet to equal acclaim at St. Ann's Warehouse in Spring 2020. In February 2021, it was announced that Negga will star in and executive produce a limited drama series about legendary Jazz age performer and civil rights activist Josephine Baker. In 2021, Negga starred in Rebecca Hall's period drama Passing opposite Tessa Thompson. The film is adapted from Nella Larsen's 1929 novel of the same name. The film premiered at the 2021 Sundance Film Festival and was shown at the New York Film Festival in the fall. Negga portrays Clare, a light-skinned Black woman in 1920s New York, navigating the color line by passing as a white woman.