Spanoulis was a key member of the team for Greece during that tournament. Greece finished in second place in the tournament, winning the silver medal. Spanoulis won a gold medal with the Greece men's national basketball team, at the 2006 FIBA Stanković World Cup tournament. On the way to that achievement, Greece defeated Australia, and then Germany (the later whose team included NBA star Dirk Nowitzki). Spanoulis was named the MVP, of both the 2007 and 2009 friendly Acropolis Tournaments, in Athens, and he also won the same tournament 9 times with the Greece national team, in the years 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2013, and 2015. Spanoulis' retirement from the Greece men's national basketball team was announced on September 17, 2015, after the 2015 EuroBasket. He ended his Greece men's national basketball team career, having been the leading scorer in every major tournament that he played in, from 2006 onward (9 tournaments in total: 2006 FIBA World Cup, 2007 EuroBasket, 2008 FIBA World Olympic Qualifying Tournament, 2008 Summer Olympics, 2009 EuroBasket, 2010 FIBA World Cup, 2012 FIBA World Olympic Qualifying Tournament, 2013 EuroBasket, and the 2015 EuroBasket). In December 2019, Greece's senior national team head coach at the time, Rick Pitino, stated that, "Just for the record, I would love to see Spanoulis join our national team”. Pitino then stated in May 2020, on Spanoulis rejoining the Greece national team, "I must say that I still want Spanoulis to play. Before the injury, I thought that Spanoulis would play. I want him to be the leader, I want him to lead the team, even if he is not 100% ready. He will have time to get back on his feet. I want him to come as a leader. We will not win with athleticism, but with intelligence and the pride of playing for Greece. Spanoulis is very important to me, I want to have him with me. I will make him an offer that he can't refuse." In his career, Spanoulis had 146 official caps with the senior men's Greek national team, in which he scored a total of 1,494 points, for a scoring average of 10.2 points per game. In all official games played with Greece's men's national team, he had a total of 211 caps, in which he scored a total of 2,314 points, for a scoring average of 11.0 points per game. Spanoulis finished