Hotel, Skye found Luke unconscious in a janitor's closet. Once she'd revived him, Luke took charge of the chaos and everyone drew numbers for the order they would be rescued by helicopter. When it was Luke's turn to leave, Skye gave him a passionate kiss goodbye. After the fire was over and they were both safe, they tried to pretend the kiss never happened. Before the fire, Edward had altered his will to make Skye his sole heir despite not being a real Quartermaine. Shocked by the news, Skye nearly fell off the wagon, helped by Tracy, who wanted ELQ for herself. Luke snapped Skye out of it and she vowed to take Tracy on sober. Justus and Tracy persuaded Edward to act senile in order to escape liability for the fire at the hotel. Tracy tried to take advantage of the situation by having Edward committed, but Edward escaped and Skye and Luke hid him at the lake house. Skye eventually realized she and Luke were not destined to be together, and she moved on with Lorenzo Alcazar. At first, the relationship was casual, but they both began to open up to each other. When a deadly virus swept Port Charles and Skye fell ill, Lorenzo switched Skye's medical chart with Lulu Spencer's so Skye would receive one of the few doses of antidote the hospital had. Skye initially resented Lorenzo for risking Lulu's life for hers, but eventually she forgave him and they resumed their relationship. Later, Skye was given a miracle when she became pregnant with Lorenzo's baby. Realizing the gift she had been given, Skye was determined to protect her child from the violence surrounding Lorenzo. With Robert Scorpio's help, Skye fled the country so she could have her in peace and live in safety far from Lorenzo's reaches. However, Lorenzo caught up with Skye just as she went into labor. After the birth of her daughter, Lila Rae, Skye realized she had no right to deny Lila a relationship with her father. To protect that connection, Skye would make some heartbreaking decisions that would drive a deep rift through her family. When one of Lorenzo's associates took the Metro Court hostage, Skye protected Lorenzo. Inside the Metro Court, Skye's father, Alan, suffered what would prove to be a fatal heart attack. Believing Lorenzo had amnesia, Skye stepped up to temporarily run Lorenzo's organization, putting both