cyanation of 4-chlorobenzotrifluoride is a precursor for the antidepressant Fluvoxamine. Benzonitrile can also act a ligand in asymmetric catalysis, coordinating to transition metals and forming Lewis acids. See also For synthesis of nitriles: Kolbe nitrile synthesis Rosenmund-von Braun reaction For reactions of nitriles: Pinner reaction Stephen aldehyde synthesis References Substitution reactions Name reactions