Spero is a surname. Notable people with the surname include: Anthony Spero (1929-2008), American criminal David Spero (born 1951), American DJ and music manager Deborah Spero, American law enforcement official Donald Spero (born 1939), American rower and venture capitalist Emji Spero, American queer performance artist Ernest Spero (1894-1960), British politician George Spero (footballer) (born 1941), Australian rules footballer Greg Spero (born 1985), American pianist and composer Joan E. Spero (born 1944), American diplomat Nancy Spero (1926–2009), American visual artist Shubert Spero (born 1923), American rabbi Stanislas Spero Adotevi (born 1934), Beninese politician Wendy Spero, American comedian