County MD 410 begins at a pair of junctions with MD 355 (Wisconsin Avenue) and MD 187 (Old Georgetown Road) on either side of Bethesda station on the Washington Metro's Red Line in downtown Bethesda. Westbound MD 410 ends at the intersection of two-way MD 355 and the southern terminus of MD 187, which begins one-way northbound along Old Georgetown Road. Traffic from the southbound direction of MD 187 follows Woodmont Avenue and Montgomery Lane to the start of eastbound MD 410 at the intersection of MD 355 and Montgomery Avenue. MD 410 heads east as a one-way pair—East–West Highway westbound and Montgomery Avenue eastbound—to the eastern edge of downtown Bethesda, where the two directions converge east of Bethesda-Chevy Chase High School. From that intersection, traffic can use a U-turn lane from Montgomery Avenue to enter westbound East–West Highway back towards MD 355 or use a merge lane to enter MD 410 heading east. From there, the highway continues east as a four-lane, undivided East–West Highway. MD 410 crosses over the Capital Crescent Trail. It then follows the northern edge of the town of Chevy Chase; crosses Coquellin Run; and runs along the southern edge of the Columbia Country Club to its intersection with MD 185 (Connecticut Avenue). MD 410 then leaves Chevy Chase and passes through an unincorporated area of Chevy Chase, within which the highway meets the northern end of MD 186 (Brookville Road). It descends into the valley of Rock Creek, where it intersects with Jones Mill Road and Beach Drive–the main road through Rock Creek Park). MD 410 then crosses over Rock Creek, passes to the north of Meadowbrook Park, and leaves the valley as a four-lane divided highway with a narrow median and flanking service roads. MD 410 reaches the top of a hill at Grubb Road and descends into the valley of a branch of Rock Creek. The highway becomes undivided at Sundale Drive and crosses the branch stream just west of the northern corner of the District of Columbia and its attendant boundary marker. It then leaves the stream valley and ascends to an intersection with MD 390 (16th Street) at the western edge of downtown Silver Spring. MD 410 intersects MD 384 (Colesville Road) next to the headquarters of the National Oceanic and Atmospheric Administration and just south of the Metro's Silver Spring station, which serves the Washington Metro's Red Line and