route meets US 20A. US 20A joins NY 64 here, following the latter for about , allowing US 20A to terminate at its parent, US 20, here concurrent with NY 5, at an intersection in East Bloomfield. At this point, NY 64 turns west onto US 20 and NY 5. The three routes head westward across mostly open fields, meeting the southern terminus of NY 444 south of the former village of Holcomb. Past the junction, which once served as the eastern terminus of NY 20C, US 20, NY 5, and NY 64 continue into the village of Bloomfield before NY 64 breaks from NY 5 and US 20 and turns northward toward Rochester once again. A mere north of US 20 and NY 5, NY 64 meets the west end of Bloomfield's West Main Street at a rural intersection that was the western terminus of NY 20C. North of West Main Street, the highway curves to the northwest as it exits East Bloomfield and enters the adjacent town of West Bloomfield. In the northeast corner of the town, NY 64 passes through the hamlet of Ionia. Northwest of the community, the route breaks to the north, taking a due north alignment as it passes into Monroe County and becomes Mendon–Ionia Road. The road stays on a relatively straight path northward as it heads through the rural southern portion of the town of Mendon to the hamlet of Mendon, where NY 64 meets NY 251 in the center of the community. On the opposite side of NY 251, NY 64 becomes Pittsford–Mendon Road. Outside of the hamlet, the highway maintains a consistent northerly alignment as it runs through slightly more populated areas of the town of Mendon and passes over the New York State Thruway (Interstate 90 or I-90). The route enters the town of Pittsford a short distance north of the Thruway, at which time NY 64 becomes Mendon Road. Within Pittsford, NY 64 passes through increasingly more populated areas as it approaches the village of Pittsford. Directly south of the village, the highway enters an intersection with South Main Street, Stone Road and Mendon Center Road at a sharp angle. NY 253 once entered this junction on Mendon Center Road and followed NY 64 into Pittsford; however, today, NY 64 continues alone onto South Main Street. The route ends just under later at the junction of South Main