stable measures from lab tests or blood pressure, for example; and expands it to define health as the flexibility of these values. Blood pressure is one of Sterling's prime examples of a health measure that is best when it can fluctuate in anticipation of the brain-body's expected demands, so it can match this demand. The alternative, or a less healthy state on the health-disease continuum, would be for blood pressure to remain the same, or "stable," and not meet the new demand. Sung Lee (2019) introduced the paradigm of allostatic orchestration (PAO), extending the principle of allostasis (as originally put forth by Peter Sterling) stating, “The PAO originates from an evolutionary perspective and recognizes that biological set points change in anticipation of changing environments.” The brain is the organ of central command, orchestrating cross-system operations to support optimal behavior at the level of the whole organism. The PAO describes differences between homeostasis and allostasis paradigms and conciliation of the paradigms illustrated with alternative views of post-traumatic stress disorder (PTSD). Lee states: The allostatic state represents the integrated totality of brain-body interactions. Health itself is an allostatic state of optimal anticipatory oscillation, hypothesized to relate to the state of criticality… Diseases are allostatic states of impaired anticipatory oscillations, demonstrated as rigidifications of set points across the brain and body (disease comorbidity). The PAO implications for health extend beyond blood pressure and diabetes to include addiction, depression, and deaths of despair (from alcohol, drugs, and suicide) that have been increasing since 2000, emphasizing that an integrated view of health includes environmental context. Allostasis encourages increased attention to new solutions at the level of society, as well as the individual and immediate community. Allostatic regulation reflects, at least partly, cephalic involvement in primary regulatory events, in that it is anticipatory to systemic physiological regulation. This is different from homeostasis, which occurs in response to subtle ebb and flow. Both homeostasis and allostasis are endogenous systems responsible for maintaining the internal stability of an organism. Homeostasis is formed from the Greek adjective homoios, meaning "similar," and the noun stasis, meaning "standing;" thus, "standing at about the same level." Wingfield states:The concept of allostasis, maintaining stability through change, is a fundamental process through which organisms actively adjust to both predictable and unpredictable events... Allostatic load refers to the cumulative cost to the body of allostasis, with allostatic overload... being a state in which serious pathophysiology