serves as a powerful reaction in the synthesis of resveratrol analogues with 3,5-bis(trifluoromethyl)phenyl sulfones. The following schematic displays the general scheme for synthesizing resveratrol analogues, where R2 is an aryl group. (−)-Callystatin A In the asymmetric total synthesis of (−)-callystatin A by Amos Smith, two separate Julia olefinations were used to append two E-alkene moieties. (−)-callystatin A is a member of the leptomycin family of antibiotics. The following schematic displays the Julia-Kocienski olefination used to achieve the precursor to the natural product, as indicated by use of the PT-sulfone. See also Horner–Wadsworth–Emmons reaction Johnson–Corey–Chaykovsky reaction Peterson olefination Wittig reaction References Julia, M.; Paris, J.-M. Tetrahedron Lett. 1973, 14, 4833–4836. () Kocienski, P. J.; Lythgoe, B.; Ruston, S. J. Chem. Soc., Perkin Trans. 1 1978, 829. Keck, G. E.; Savin, K. A.; Weglarz, M. A. J. Org. Chem. 1995, 60, 3194–3204. () Kocienski, P. J. Phosphorus and Sulfur 1985, 24, 97–127. (Review) Kelly, S. E. Comprehensive Organic Synthesis 1991, 1, 792–806. (Review) () Blakemore, P. R. J. Chem. Soc., Perkin Trans. 1 2002, 2563–2585. () Baudin, J. B.; Hareau, G.; Julia, S. A.; Ruel, O. Tetrahedron Lett. 1991, 32, 1175. () Truce, W. E.; Kreider, E. M.; Brand, W. W. Org. React. 1970, 18, 99. (Review) Paul R. Blakemore, William J. Cole, Philip J. Kocieński, Andrew Morley Synlett 1998, 26–28. () Christophe Aïssa J. Org. Chem. 2006, 71, 360–63. () Zajc, B., & Kumar, R. (2010). Synthesis of Fluoroolefins via Julia-Kocienski Olefination. Synthesis, 2010(11), 1822–1836.() Langcake, P.; Pryce, R. J. (1977). "A new class of phytoalexins from grapevines". Experientia 33 (2): 151–2. () . Moro, A. V.; Cardoso, F. S. P.; Correia, C. R. D. Heck arylation of styrenes with arenediazonium salts: Short, efficient, and stereoselective synthesis of resveratrol, DMU-212, and analogues. Tetrahedron Lett. 2008, 49(39), 5668–5671. Prabhakar Peddikotla, Amar G. Chittiboyina, Ikhlas A. Khan, (2014) ChemInform Abstract: Synthesis of Pterostilbene by Julia Olefination. ChemInform 45, . Alonso DA, Fuensanta M, Nájera C, Varea M. J. Org. Chem. 2005; 70:6404–6416. . A. B. Smith, III and B. M. Brandt. Total Synthesis of (–)-Callystatin A. Org. Lett. 2001, 3, 1685–1688. Robiette, R.; Pospíšil, J. On the Origin of E/Z Selectivity in the Modified Julia Olefination: Importance of the Elimination Step; Eur. J. Org. Chem. 2013, 836–840. External links Julia-Lythgoe Olefination Julia Olefination Julia-Kocienski Olefination Olefination reactions Carbon-carbon bond forming reactions Addition reactions Free radical reactions Name reactions