Krka, d. d., Novo mesto is an international generic pharmaceutical company with headquarters in Novo Mesto, Slovenia. As well as a number of companies and representative offices abroad, Krka also had production and distribution centers in Russia, Poland, Croatia, and Germany. Krka sells products to more than 70 countries. In 2018, Krka Group’s total sales amounted to 1.332 billion euros. Over the previous five years, average annual sales growth had been at 2.9% rate. At the end of 2018, Krka Group had 11,390 employees. Activities and products Krka’s business is founded on pharmaceutical and chemical activities. Prescription pharmaceuticals remain its main product group, with an 82.6% share of Krka Group’s total sales. They are followed in sales volume by non-prescription products (9.4%) and animal health products (5%). Its Terme Krka spas, hotels and tourism subsidiary contributed 2.8% of the parent group's sales volume. Prescription pharmaceuticals The most important of Krka’s therapeutic groups include treatments for: cardiovascular diseases, alimentary tract diseases and metabolic disorders, and central nervous system diseases. They are followed by the medicines for the systemic treatment of infections, the medicines for the treatment of diseases of the blood and blood-forming organs, and the medicines for urinary tract diseases as well as the medicines for respiratory system diseases. Its portfolio of treatments for cardiovascular disease include ACE inhibitors to treat high blood pressure (including enalapril and perindopril), sartans for those unable to tolerate ACE inhibitors (including losartan, valsartan and telmisartan), statins to reduce high cholesterol levels (including simvastatin, atorvastatin and rosuvastatin) and clopidogrel, a blood clot inhibitor. The company makes proton pump inhibitors for the treatment of ulcers and reflux are the key group among the medicines for the treatment of alimentary tract diseases and metabolic disorders (lansoprazole, pantoprazole, esomeprazole). In the group of medicines for the treatment of central nervous system diseases, Krka produces antidepressants (venlafaxine, sertraline), antipsychotics (olanzapine, quetiapine), as well as medicines for the treatment of Parkinson’s and Alzheimer’s diseases. An important indication area also includes anti-microbial products (clarithromycin). Krka’s range of products includes analgesics, medicines for the treatment of diseases of the respiratory system, benign prostatic hyperplasia, and type-2 diabetes. Non-prescription products Krka’s non-prescription products are aimed at preventing diseases and treating minor illnesses which do not require medical attention. They include products with an effect on the mouth cavity and the pharynx (Septolete), vitamin and mineral products (Pikovit and Duovit), medicines for cough and