indicated as first line therapy for MALT lymphomas. About 80% of MALT lymphomas completely regress with eradication therapy. Radiation treatment for H. pylori–negative gastric malt lymphoma, has a high success rate, 90% or better after 5 years. Second line therapy for MALT lymphomas is usually chemotherapy with a single agent, and complete response rates of greater than 70% have been reported. Subtotal gastrectomy, with post-operative chemotherapy is undertaken in refractory cases, or in the setting of complications, including gastric outlet obstruction. See also Lymphoepithelial lesion References Gastrointestinal cancer Non-Hodgkin lymphoma