as the Visconti and Sforza of Milan, the Este of Ferrara, and the Gonzaga of Mantua. Greatest artists like Brunelleschi, Botticelli, Da Vinci, Michelangelo, Giotto, Donatello, Titian and Raphael produced inspired works – their paintwork was more realistic-looking than had been created by Medieval artists and their marble statues rivalled and sometimes surpassed those of Classical Antiquity. Michelangelo carved his masterpiece David from marble between 1501 and 1504. Humanist historian Leonardo Bruni, split the history in the antiquity, Middle Ages and modern period. Churches began being built in the Romanesque style for the first time in centuries. While art and architecture flourished in Italy and then the Netherlands, religious reformers flowered in Germany and Switzerland; printing was establishing itself in the Rhineland and navigators were embarking on extraordinary voyages of discovery from Portugal and Spain. Around 1450, Johannes Gutenberg developed a printing press, which allowed works of literature to spread more quickly. Secular thinkers like Machiavelli re-examined the history of Rome to draw lessons for civic governance. Theologians revisited the works of St Augustine. Important thinkers of the Renaissance in Northern Europe included the Catholic humanists Desiderius Erasmus, a Dutch theologian, and the English statesman and philosopher Thomas More, who wrote the seminal work Utopia in 1516. Humanism was an important development to emerge from the Renaissance. It placed importance on the study of human nature and worldly topics rather than religious ones. Important humanists of the time included the writers Petrarch and Boccaccio, who wrote in both Latin as had been done in the Middle Ages, as well as the vernacular, in their case Tuscan Italian. As the calendar reached the year 1500, Europe was blossoming – with Leonardo da Vinci painting his Mona Lisa portrait not long after Christopher Columbus reached the Americas (1492), Amerigo Vespucci proofed that America is not a part of India and hence the new world derived from his name, the Portuguese navigator Vasco Da Gama sailed around Africa into the Indian Ocean and Michelangelo completed his paintings of Old Testament themes on the ceiling of the Sistine Chapel in Rome (the expense of such artistic exuberance did much to spur the likes of Martin Luther in Northern Europe in their protests against the Church of Rome). For the first time in European history, events North of the Alps and on the Atlantic Coast were taking centre stage. Important artists of this period included