Isaakio () is a village of Evros regional unit in Greece, part of the municipality Didymoteicho. It is located 5 kilometers east of Didymoteicho. Its population according to the 2011 census was 407. References External links buk.gr MeetGreece.eu See also List of settlements in the Evros regional unit Didymoteicho Populated places in Evros (regional unit)