Irene, Princess Henry of Prussia, Ernest Louis, Grand Duke of Hesse and by Rhine, Prince Friedrich, Alexandra Feodorovna, Empress of Russia, Princess Marie of Hesse and by Rhine Prince Alfred, Duke of Saxe-Coburg and Gotha (1844–1900) Issue: Alfred, Hereditary Prince of Saxe-Coburg and Gotha, Marie, Queen of Romania, Victoria Melita, Grand Duchess of Russia, Alexandra, Princess of Hohenlohe-Langenburg, Princess Beatrice, Duchess of Galliera Helena, Princess Christian of Schleswig-Holstein (1846–1923) Issue: Prince Christian Victor, Albert, Duke of Schleswig-Holstein, Princess Helena Victoria, Princess Marie Louise, Prince Harald Princess Louise, Duchess of Argyll (1848–1939) No issue Prince Arthur, Duke of Connaught and Strathearn (1850–1942) Issue: Margaret, Crown Princess of Sweden, Prince Arthur of Connaught, Princess Patricia, Lady Ramsay Prince Leopold, Duke of Albany (1853–1884) Issue: Princess Alice, Countess of Athlone, Charles Edward, Duke of Saxe-Coburg and Gotha Beatrice, Princess Henry of Battenberg (1857–1944) Issue: Alexander Mountbatten, 1st Marquess of Carisbrooke, Victoria Eugenie, Queen of Spain, Lord Leopold Mountbatten, Prince Maurice of Battenberg Princess Alice Alice (1843–1878), Victoria's third child, and wife of the future Grand Duke Louis IV of Hesse and by Rhine (1837–1892), passed it on to at least three of her children: Irene, Friedrich, and Alix. Princess Victoria of Hesse and by Rhine (1863–1950), later Marchioness of Milford Haven, wife of Prince Louis of Battenberg (1854–1921) and maternal grandmother to Prince Philip, Duke of Edinburgh, apparently was not a carrier. Princess Elizabeth of Hesse and by Rhine (1864–1918), later Grand Duchess Elizabeth Feodorovna of Russia through her marriage to Grand Duke Sergei Alexandrovich (1857–1905), may or may not have been a carrier. Following her husband's assassination, she became a nun and was childless when killed by the Bolsheviks in 1918. Princess Irene of Hesse and by Rhine (1866–1953), later Princess Heinrich of Prussia, through her marriage to Prince Heinrich of Prussia (1862–1929), passed it on to two of her three sons: Prince Waldemar of Prussia (1889–1945). Survived to age 56; had no issue. Prince Heinrich of Prussia (1900–1904). Died at age 4. Prince Friedrich of Hesse and by Rhine (1870–1873). Died before his third birthday of bleeding on the brain resulting from a fall from a third-story window (which would almost certainly have not been fatal if he had not had haemophilia). Princess Alix of Hesse and by Rhine (1872–1918), later Empress Alexandra Feodorovna of Russia through her marriage to Tsar Nicholas II (1868–1918). Alix had a marriage proposal from her