Rogen as Ben Stone Katherine Heigl as Alison Scott Paul Rudd as Pete Leslie Mann as Debbie Jason Segel as Jason Jay Baruchel as Jay Jonah Hill as Jonah Martin Starr as Martin Charlyne Yi as Jodi Iris Apatow as Charlotte Maude Apatow as Sadie Harold Ramis as Harris Stone Joanna Kerns as Mrs. Scott Alan Tudyk as Jack Kristen Wiig as Jill Bill Hader as Brent Ken Jeong as Dr. Kuni J. P. Manoux as Dr. Angelo Tim Bagley as Dr. Pellagrino B. J. Novak as Doctor Mo Collins as Doctor Loudon Wainwright as Dr. Howard Adam Scott as Samuel the Nurse Craig Robinson as Club Doorman Tami Sagher as Wardrobe Lady Stormy Daniels as Lap Dancer Nick Thune as Alison's Friend Themselves (uncredited) Jessica Alba Steve Carell Andy Dick James Franco Eva Mendes Ryan Seacrest Dax Shepard Production Several of the major cast members return from previous Judd Apatow projects: Seth Rogen, Martin Starr, Jason Segel, and James Franco all starred in the television series Freaks and Geeks which Apatow produced. From the Apatow-created Undeclared (which also featured Rogen, Segel and Starr) there are Jay Baruchel and Loudon Wainwright III. Paul Feig, who co-created Freaks and Geeks, starred in the Apatow-written movie Heavyweights and directed the Apatow-produced Bridesmaids also makes a brief cameo as the Fantasy Baseball Guy. Steve Carell, who makes a cameo appearance as himself, played the main role in Apatow's The 40-Year-Old Virgin which also starred Rogen and Rudd, as well as appearing in the Apatow-produced Anchorman. Finally, Leslie Mann, who also appeared in The 40-Year-Old Virgin and Freaks and Geeks, is married to Apatow and their two daughters play her children in the movie. Anne Hathaway was originally cast in the role of Alison in the film, but dropped out due to creative reasons that Apatow attributed to Hathaway's disagreement with plans to use real footage of a woman giving birth. Jennifer Love Hewitt and Kate Bosworth auditioned for the part after Hathaway dropped out, but ended up losing out to Katherine Heigl. Christina Aguilera was a contender for the main role but decided to turn it down because she was promoting her album Back to Basics at the time. The closing credits roll over cast members' baby photos. The image of Joanna Kerns as a young mother was previously famous from its use in opening credits of Growing Pains''' first few seasons. Bennett