In 2001, Holmes appeared on Lily Savage's Blankety Blank. In 2013, Holmes was a judge on the CBBC Blue Peter talent search for a new presenter, Blue Peter – You Decide. Holmes has made four appearances on the long-running game show Who Wants to be a Millionaire?. The first time, he played with Alex Ferguson on 25 December 2004. On 25 August and 1 September 2007, he played with Kay Burley. On 20 May 2012, he returned with Ruth Langsford by his side. Finally, on 19 December 2013, to celebrate the end of Millionaire on ITV, Holmes re-appeared on the show with Alex Ferguson. Holmes has also appeared on celebrity editions of game shows including Fifteen to One, Call My Bluff, All Star Mr & Mrs, Tipping Point: Lucky Stars, Catchphrase and The Chase. Holmes has also made regular appearances on Big Brother's Bit on the Side and in 2015, he was heavily tipped as a housemate for Celebrity Big Brother 16. He has been a panellist on numerous episodes of Through the Keyhole and appeared in ITV's Guess the Star in 2017. Since November 2017, he has provided the voiceover for Biggleton on CBeebies. On 19 September 2021, Eamonn Holmes was featured on "The Meaning of Life" on RTE Television, Ireland. Radio Holmes' foray into radio broadcasting was at Downtown Radio, Northern Ireland's first commercial independent radio station, in the late 1980s. From around 2003, Holmes presented The Eamonn Holmes Show on Radio 5 Live on Saturday mornings between 9 and 11 am for 6 years, last airing on 30 May 2009 as Holmes' contract with the BBC was not renewed. In 2005, Holmes hosted his own programme on London radio station Magic 105.4. For a few weeks in 2008, Holmes took over Michael Parkinson's Sunday morning show on Radio 2. In 2016, Holmes presented his own radio show on talkRADIO. The show was called Let's Talk With Eamonn Holmes and was broadcast on Saturdays from 6am to 8am and Sundays from 11am to 1pm. From January 2018 till February 2020, Holmes presented the weekday drivetime show on talkRADIO. Other work Holmes writes a column for The People newspaper. His autobiography was released in May 2006. The autobiography is called This is MY Life, a reference to another famous Irish Eamonn – Eamonn Andrews, after whom he was named. The book reveals some of what occurred behind the scenes