discover methods of targeting cancer metabolism. The trio have contributed immensely in a few years to what was originally a forgotten paradigm. The discovery of the involvement of particular enzymes such as PKM2, mutated IDH as well as novel oncometabolites such as 2-hydroxyglutarate in cancer development have once again brought cancer metabolism back to the forefront of cancer biology. On August 1, Agios announced that the FDA had approved their lead compound, IDHIFA®, for the treatment of acute myeloid leukemia. IDHIFA® targets a mutant form of Isocitrate dehydrogenase 2 and is the first drug specifically targeting cancer metabolism to be used for cancer treatment. Mak holds Honorary Doctoral Degrees from numerous universities in North America and Europe. He is an Officer of the Order of Canada and has been elected a Foreign Associate of the National Academy of Sciences (USA) as well as a Fellow of the Royal Society of London (UK.) He has won international recognition in the forms of the Emil von Behring Prize, the King Faisal Prize for Medicine, the Gairdner Foundation International Award, the Sloan Prize of the General Motors Cancer Foundation, the Paul Ehrlich and Ludwig Darmstaedter Prize, the Novartis Prize in Immunology, and the Szent-Györgyi Prize for Progress in Cancer Research. Honors 1985, awarded the Steacie Prize 1986, elected a Fellow of the Royal Society of Canada 1988, awarded the Emil von Behring Prize 1989, awarded the Gairdner Foundation International Award 1990, awarded the Royal Society of Canada's McLaughlin Medal 1994, made a Fellow of the Royal Society 1995, awarded the King Faisal Prize for Medicine 1996, awarded the Robert L. Noble Prize by the National Cancer Institute of Canada 1996, awarded the Sloan Prize of the General Motors Cancer Foundation 2000, made an Officer of the Order of Canada 2002, elected as a foreign associate to the National Academy of Sciences in the discipline of immunology 2003, awarded the Killam Prize by the Canada Council for the Arts. 2004, awarded the Paul Ehrlich and Ludwig Darmstaedter Prize 2005, elected as an International Honorary Member of the American Academy of Arts and Sciences. 2007, awarded the Order of Ontario. 2009, introduced to the Canadian Medical Hall of Fame. 2015, award the Top 25 Canadian Immigrant Awards. 2021, awarded the Szent-Györgyi Prize for Progress in Cancer Research Select publications References External links University of Toronto biography University Health Network Profile 1946 births Living people Canadian