of the song's first reviews, The Washington Post stated, "dashing through the tune as if it were a power ballad on speed, Flowers and company had the capacity crowd pulsing along with glee." "Mr. Brightside" became a popular song within the Las Vegas music scene with one reviewer calling it a "feel-good anthem that ranks as one of the best local tracks in a long time". In positive reviews, NME said the song was filled with "ambition, sex, and noise" while Rolling Stone described the song as having "swelled with anthemic majesty". The Guardian considered "Mr. Brightside" to be the most overplayed song, and noted that it has been played "on the radio. In the supermarket. In the pub. The office. In a cab. Thrumming through your neighbours' wall. [...] Blasted out at every party or wedding you’ll attend for the rest of your life." In 2020, Paste ranked the song number three on their list of the 20 greatest Killers songs, and in 2021, American Songwriter ranked the song number one on their list of the 10 greatest Killers songs. Commercial performance "Mr. Brightside" entered the Billboard Hot 100 at No. 40 on February 12, 2005, and peaked at No. 10 on June 11, thus making it a sleeper hit. The song reached 3.5 million in sales in 2016. In 2005, "Mr. Brightside" was the sixth most downloaded song on iTunes. To this day "Mr. Brightside" still has the highest popularity rating that iTunes offers, even after being available for purchase for over ten years. Additionally, sales of Hot Fuss album reached over 5 million sales by 2006. The online music streaming service Last.fm reported in 2010 that "Mr. Brightside" was the most downloaded song on the website. By July 2014, the song sold more than 820,000 copies in the United Kingdom, making it the UK's No. 12 most downloaded rock track of all time. As of April 2021, "Mr. Brightside" has spent 260 non-consecutive weeks, or five years, on the UK Singles Chart, the most out of any song. , it had charted on the UK Singles Chart in 11 of the last 13 years, including a 35-week run peaking at number 49 in 2016–2017. It was the UK's most streamed pre-2010 song, until it was surpassed by Oasis' "Wonderwall" in late 2018, and continued to be purchased for download hundreds of times a week by 2017. In