with an amine is versatile a way of forming tropinones. The mechanism evoked is clearly delineated to be a double Michael reaction (i.e. conjugate addition). Biochemistry method Reduction of tropinone The reduction of tropinone is mediated by NADPH-dependent reductase enzymes, which have been characterized in multiple plant species. These plant species all contain two types of the reductase enzymes, tropinone reductase I and tropinone reductase II. TRI produces tropine and TRII produces pseudotropine. Due to differing kinetic and pH/activity characteristics of the enzymes and by the 25-fold higher activity of TRI over TRII, the majority of the tropinone reduction is from TRI to form tropine. See also Benztropine Daturaolone 2-Carbomethoxytropinone (2-CMT) an intermediate in the creation of ecgonine cocaine analogues Ecgonidine References External links MSDS for tropinone Tropane alkaloids Ketones Total synthesis