In the brain, the interventricular foramina (or foramina of Monro) are channels that connect the paired lateral ventricles with the third ventricle at the midline of the brain. As channels, they allow cerebrospinal fluid (CSF) produced in the lateral ventricles to reach the third ventricle and then the rest of the brain's ventricular system. The walls of the interventricular foramina also contain choroid plexus, a specialized CSF-producing structure, that is continuous with that of the lateral and third ventricles above and below it. Structure The interventricular foramina are two holes (, pl. foramina) that connect the left and the right lateral ventricles to the third ventricle. They are located on the underside near the midline of the lateral ventricles, and join the third ventricle where its roof meets its anterior surface. In front of the foramen is the fornix and behind is the thalamus. The foramen is normally crescent-shaped, but rounds and increases in size depending on the size of the lateral ventricles. Development The development and shape of the ventricular system relates to the differential development of different parts of the brain, with the ventricular system ultimately arising from the neural tube. The lateral ventricles remain connected to the third ventricle throughout development, themselves developing as outpouchings from the third ventricle. The foramina develop slowly in a forward and outward direction as the fornix grows in size. Function The interventricular foramina connect the lateral ventricles to the third ventricle. This allows cerebrospinal fluid produced in the lateral ventricles to reach the third ventricle and then the rest of the brain's ventricular system. The walls of the interventricular foramina contain choroid plexus, a specialized structure that produces cerebrospinal fluid. The choroid plexus of the third ventricles continues through the foramina into the lateral ventricles. End branches of the medial posterior choroidal arteries, superior thalamostriate, superior choroid veins and septal veins also pass through the foramen. Clinical significance The interventricular foramina give rise to disease when they are narrowed or blocked. Narrowing of the foramen is more common in children and linked to: inflammation and scarring from congenital infections, particularly TORCH infections; developmental abnormalities, including of the basilar artery and choroid plexus; and abnormal surrounding tissue growths, such as colloid cysts, subependymal giant-cell tumours, nodules and harmatomas. The most common symptom of blockage is headache; other symptoms include fainting, dementia, and coma, all of which are associated with obstructive hydrocephalus of