Simplicius may refer to: Persons Pope Simplicius (d. 483 AD) Simplicius of Cilicia (d. c. 560 AD), philosopher Saint Simplicius, legendary 'founding' bishop of the Sardinian Diocese of Civita Simplicius, Constantius and Victorinus (fl. 2nd century), Roman martyrs and saints Simplicius, Faustinus and Beatrix (d. 302 or 303 AD), Roman martyrs and saints Art and fiction Simplicius Simplicissimus, a picaresque novel about the character of the same name Simplicius (operetta), an operetta by Johann Strauss II A character in Dialogue Concerning the Two Chief World Systems, a 1632 work by Galileo