The Religious Society of Friends began as a proto-evangelical Christian movement in England in the mid-17th century in Lancashire. Members are informally known as Quakers, as they were said "to tremble in the way of the Lord". The movement in its early days faced strong opposition and persecution, but it continued to expand across the British Isles and then in the Americas and Africa. The Quakers, though few in numbers, have been influential in the history of reform. The colony of Pennsylvania was founded by William Penn in 1682, as a safe place for Quakers to live and practice their faith. Quakers have been a significant part of the movements for the abolition of slavery, to promote equal rights for women, and peace. They have also promoted education and the humane treatment of prisoners and the mentally ill, through the founding or reforming of various institutions. Quaker entrepreneurs played a central role in forging the Industrial Revolution, especially in England and Pennsylvania. During the 19th century, Friends in the United States suffered a number of secessions, which resulted in the formation of different branches of the Religious Society of Friends. The Quakers have historically believed in equality for men and women. Two Quaker women are part of the history of science, specifically astronomy. Jocelyn Bell Burnell, from Northern Ireland, is credited with being a key part of research that later led to a Nobel Prize Physics. However, she was not a recipient of the prize. Maria Mitchell (1818-1889) was the first internationally known woman to work as both a professional astronomer and a professor of astronomy. George Fox and the Religious Society of Friends When George Fox was eleven, he wrote that God spoke to him about "keeping pure and being faithful to God and man." After being troubled when his friends asked him to drink alcohol with them at the age of nineteen, Fox spent the night in prayer and soon afterwards, he left his home to search for spiritual satisfaction, which lasted four years. In his Journal, at age 23, he recorded the words: At this time, Fox believed that he "found through faith in Jesus Christ the full assurance of salvation." Fox began to spread his evangelical Christian message and his emphasis on "the necessity of an inward transformation of heart", as well as the possibility of Christian perfection, drew opposition from English clergy and laity. Fox