comedy alongside Prithviraj Sukumaran, Kunchako Boban, Jayasurya, and Bhavana under director Kamal. Her performance was appreciated and the film was a high commercial success. Among the five main characters, the one who scored the most was again Meera. She rose to fame in Malayalam cinema with the film Kasthooriman directed by her mentor Lohithadas, where she played a happy go lucky yet emotionally complex character. She received her first Filmfare award for her performance in Kasthooriman. The film was a success at the box office, running for 100 days. The same year, she acted in T. V. Chandran's acclaimed Padam Onnu Oru Vilapam. She played a 15-year-old Muslim girl who was forced to marry an older man, for which she was awarded a State Award and the National Award in addition with several other awards. It was followed by her performance as Raziya in Perumazhakkalam alongside Kavya Madhavan. In the film Achuvinte Amma (2005), she enacted the young, adorable character Achu. She then paired with Mohanlal in Rasathanthram (2006). She played as a girl pretending to be a boy due to the pressure of circumstances in the first half of the film . The film went on to become a commercial success. Her next film with Dileep – Vinodayathra, which again was directed by Sathyan Anthikkad. She was next featured opposite Mammootty in the critically acclaimed film Ore Kadal. The film was showcased in film festivals and won awards. Her performance as an innocent middle-class woman won praise from audiences. Media quoted her as, "Matching step with the megastar in this histrionic race is Meera Jasmine, who amazes you with a stunning delineation of her difficult role" . Her next film was Calcutta News with Dileep. Blessy, who introduced her to film field, was the director of Calcutta News. In Innathe Chintha Vishayam (2008), she collaborated with Sathyan Anthikkad for his fourth consecutive film, again opposite Mohanlal, but failed to succeed. Her next films Minnaminnikoottam with Kamal and Rathri Mazha with Lenin Rajendran, which released after a long post-production delay, were box office failures. More than a year later, she played the role of a playback singer in Rajeev Anchal's Paattinte Palazhy. Though the film was commercially not successful, her character was noted and her performance gave her a comeback. Her next film, Four Friends, was a multi-starrer directed by Saji Surendran. She played the role of a cancer patient