and clinical experiments suggest that the symptoms of the disease may be alleviated by adequate dose of genistein. Genistein was found to also possess toxic properties toward brain cells. Among many pathways stimulated by genistein, autophagy may explain the observed efficiency of the substance as autophagy is significantly impaired in the disease. Cognition A study looking at Italians older than 50 found that those with the highest genistein intake had the lowest odds of cognitive impairment. Related compounds Genistin is the 7-O-beta-D-glucoside of genistein. Wighteone can be described as 6-isopentenyl genistein KBU2046 under investigation for prostate cancer. B43-genistein, an anti-CD19 antibody linked to genistein e.g. for leukemia. See also (S)-Equol Liquiritigenin Menerba References External links Compound Summary at NCBI PubChem Fact Sheet at Zerobreastcancer Information at Phytochemicals Chemical Compound Review at Wikigenes Information at Chemicalbook Description at SpringerReference Description at NCI Drug Dictionary 3α-Hydroxysteroid dehydrogenase inhibitors 21-Hydroxylase inhibitors Dietary supplements Flavonoid antioxidants GPER agonists Isoflavones Nutrients Protein kinase inhibitors Phytoestrogens Glycine receptor antagonists Selective ERβ agonists Steroid sulfotransferase inhibitors