Dermacentor variabilis, also known as the American dog tick or wood tick, is a species of tick that is known to carry bacteria responsible for several diseases in humans, including Rocky Mountain spotted fever and tularemia (Francisella tularensis). It is one of the best-known hard ticks. Diseases are spread when it sucks blood from the host. It may take several days for the host to experience symptoms. Though D. variabilis may be exposed to Borrelia burgdorferi, the causative agent of Lyme disease, these ticks are not competent vectors for the transmission of this disease. The primary vectors for B. burgdorferi are the deer ticks Ixodes scapularis in eastern parts of the United States, Ixodes pacificus in California and Oregon, and Ixodes ricinus in Europe. D. variabilis may also carry Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis, and Ehrlichia chaffeensis, the causative agent of human monocytic ehrlichiosis. Dermacentor ticks may also induce tick paralysis by elaboration of a neurotoxin that induces rapidly progressive flaccid quadriparesis similar to Guillain–Barré syndrome. The neurotoxin prevents presynaptic release of acetylcholine from neuromuscular junctions. Life cycle The life cycle of ticks can vary depending on the species. Most ticks go through four stages: egg, six-legged larva, eight-legged nymph, and adult. After hatching from the egg, a tick must obtain a blood meal at every stage to survive. Ticks can feed on mammals, birds, reptiles, and amphibians. Unlike most tick species, D. variabilis prefers the same host during all of its life stages. Distribution and seasonal activity Within North America, the normal range is in the eastern part of the continent, with some reports in California. At the northernmost extent of its geographical range, in Nova Scotia and Massachusetts, ticks are active from April to August, with a peak in May to June. In coastal Virginia, the adults are active from April to September or October, with peaks in May and July. Seasonal activity in Ohio is from late April to September, with peaks in May to June and another smaller peak in August to September. In Georgia, adults are active from late March to August, with peaks in early May, late May, and late June. Florida adult activity is from April to July, with activity being restricted by high summer temperatures and low winter humidity. Disease transmission Feeding ticks transmit pathogens to the host. Depending on the tick species and its stage of life,