Prozac Nation is a 2001 psychological drama film directed by Erik Skjoldbjærg, starring Christina Ricci, Jason Biggs, Anne Heche, Michelle Williams, Jonathan Rhys Meyers, and Jessica Lange. It is based on Elizabeth Wurtzel's 1994 memoir of the same name, which describes Wurtzel's experiences with atypical depression. The title is a reference to Prozac, the brand name of an antidepressant she was prescribed. Plot Elizabeth "Lizzie" Wurtzel is a 19-year-old accepted into Harvard with a scholarship in journalism. She has been raised by her divorced mother since she was two years old and has not seen her father at all in the last four years. Despite his lack of interest and involvement, Lizzie still misses her father, a contributing factor to her depression. Through a series of flashbacks, it is clear that there was a total communication breakdown between Lizzie's parents, which is soon reflected in Lizzie's own relationship with her mother. Soon after arriving at Harvard, Lizzie decides to lose her virginity to an older student, Noah. Lizzie proceeds to alienate Noah by throwing a loss-of-virginity party immediately afterwards with the help of her roommate Ruby. Although she and Lizzie begin as best friends, Ruby soon becomes another casualty of Lizzie's instability. Although Lizzie's article for the local music column in The Harvard Crimson is presented an award by Rolling Stone early into the semester, Lizzie soon finds herself unable to write, stuck in a vicious cycle with substance abuse. She begins a relationship with another student, Rafe, but after travelling to his home in Texas and discovering that his sister has an intellectual disability, Lizzie accuses Rafe of being 'a creepy voyeur' who gets off on witnessing the pain of others. Rafe breaks up with her. Lizzie's promising literary career is at risk, as is her mental and physical health. Her mother sends her to expensive psychiatric sessions towards which her father, pleading poverty, implacably refuses to contribute anything at all. After a long period of treatment under medication and a suicidal gesture, Lizzie stabilizes and begins to adjust to her life. Cast Christina Ricci as Elizabeth Wurtzel Zoe Miller as young Elizabeth Wurtzel Jason Biggs as Rafe Anne Heche as Dr. Sterling Michelle Williams as Ruby Jonathan Rhys Meyers as Noah Jessica Lange as Lynne Wurtzel Jesse Moss as Sam Nicholas Campbell as Donald Wurtzel, Elizabeth's father Lou Reed as himself Release The film had its world premiere