AHCC is the abbreviation of "active hexose correlated compound" which is an alpha-glucan rich nutritional supplement produced from the mycelia of shiitake (Lentinula edodes) of the basidiomycete family of mushrooms. The product/supplement/compound-mix is a subject of research as a potential anti-cancer agent but has not been conclusively found to treat cancer or any other disease, and there are conflict of interest concerns about the published research. AHCC is a popular alternative medicine in Japan. AHCC is a registered trademark of and manufactured by Amino Up Co., Ltd. in Sapporo City, Hokkaido, Japan. Development and Chemical composition AHCC was developed by Amino Up Chemical Co., LTD. and Dr. Toshihiko Okamoto (School of Pharmaceutical Sciences, University of Tokyo) in 1989. Polysaccharides form a large part of the composition of AHCC. These include beta-glucan (β-glucan) and acetylated α-glucan. Acetylated α-glucan, produced by culturing the mushroom mycelia, is unique to AHCC. Approximately 20% of the make up of AHCC is α-glucans. Glucans are saccharides, of which some are known to have immune stimulating effects. There is also a patent application in Turkiye. Depending on that AminoUp is the founder of AHCC with the first registered patent. However, the patent has expired and there are producers of AHCC which can be found in Alibaba Search with "AHCC". Potential Mechanisms of Action The manufacturer of AHCC states that the culturing process utilized in its manufacture favors the release of small bioactive molecules that act as nontoxic agonists for toll-like receptors (TLRs), specifically TLR-4, initiating a systemic anti-inflammatory response. AHCC is believed to bind to TLR-2 and TLR-4, and act as an immune modulator, as Immune cells such as CD4+ and CD8+ T cells and natural killer (NK) cells will produce cytokines by either cytokine stimulation by dendritic cells or ligand binding to TLRs. Use in Integrative Medicine AHCC is widely used in Japan and China. It is available to the general public in Japan and China without a prescription and many people use it for general health maintenance and treatment of acute infections. It is often used as a Complementary and Alternative Medicine (CAM) for immune support, as reports in animal and clinical settings have indicated that AHCC is associated with an enhanced response to infection and increased survival. AHCC is in some cases also used by those undergoing conventional cancer therapy (e.g. chemotherapy) for its reported immunomodulatory functions. In Japan, AHCC is the 2nd most