in a truncated protein have been associated with phosphorylase deficiency in muscle, cytochrome c oxidase deficiency in liver, severe congenital hypotonia, hepatomegaly, and liver failure. This expands on the current understanding of McArdle disease and suggests that this combination of mutations could result in a complex disease with severe phenotypes. Interactions PYGM has been shown to have 64 binary protein-protein interactions including 21 co-complex interactions. PYGM appears to interact with PRKAB2, WDYHV1, PYGL, PYGB, 5-aminoisatin, 5-nh2_caproyl-isatin, PHKG1, PPP1CA, PPP1R3A, DEGS1, SET, MAP3K3, INPP5K, PACSIN3, CLASP2, NIPSNAP2, SRP72, LMNA, TRAPPC2, DNM2, IGBP1, SGCG, PDE4DIP, PPP1R3B, ARID1B, TTN, INTS4, FAM110A, TRIM54, TRIM55, WWP1, AGTPBP1, POMP, and CDC42BPB. References External links Transferases EC 2.4.1