was reduced, but that the peroxy group survived. However, the lactone of deoxyartemisinin resisted reduction with sodium borohydride and could only be reduced with diisobutylaluminium hydride to the lactol deoxydihydroartimisinin. These results show that the peroxy group assists the reduction of lactone with sodium borohydride to a lactol, but not to the alcohol which is the over-reduction product. No clear evidence for this reduction process exists. Society and culture In combination with piperaquine, brands include: D-Artepp (GPSC) Artekin (Holleykin) Diphos ( Genix Pharma) TimeQuin ( Sami Pharma ) Eurartesim (Sigma Tau; by Good Manufacturing Practices) Duocotecxin (Holley Pharm) Alone (not recommended by WHO due to risk of resistance development): Cotecxin (Zhejiang Holley Nanhu Pharmaceutical Co.) Research Accumulative research suggests that dihydroartemisinin and other artemisinin-based endoperoxide compounds may display activity as experimental cancer chemotherapeutics. Recent pharmacological evidence demonstrates that dihydroartemisinin targets human metastatic melanoma cells with induction of NOXA-dependent mitochondrial apoptosis that occurs downstream of iron-dependent generation of cytotoxic oxidative stress. See also Tu Youyou References Further reading External links Antimalarial agents Organic peroxides Trioxanes Chinese discoveries Oxygen heterocycles Heterocyclic compounds with 4 rings Tetracyclic compounds Lactols