popular complementary and alternative medicine used by cancer patients. Agaricus blazei supplements are the most popular, outpacing AHCC use by a factor of 7:1. Research Nearly all of the research into AHCC has been funded by the manufacturer, which complicates the discussion of currently available results – independent research is needed to verify them. The mechanism of action of AHCC is poorly understood and there is little known about its safety. clinical research into AHCC has been of poor quality: there are no large-scale studies or randomized controlled trials. Laboratory research suggests AHCC may have immunostimulatory effects. AHCC has been proposed as a treatment for cancer, but research into its effectiveness has produced only uncertain and inconclusive evidence. Detailed research is needed into the pharmacology of AHCC before any recommendation of its use as an adjuvant therapy can be made. Studies have suggested that AHCC supplementation may affect immune outcomes and immune cell populations, suggesting that it has anti-inflammatory effects. Moreover, available data have demonstrated that AHCC may possibly reduce symptoms, improve survival, and shorten recovery time in animal models infected with viruses, bacteria, and fungal infections. Are there any other AHCC producers? See also Alternative cancer treatments Agaricus blazei mushroom Medicinal mushrooms Shiitake References Immune system Cancer research Dietary supplements