sites, two EF-hand-like calcium-binding motifs, and two polyproline domains. These proline-rich stretches are characteristic of SH3-binding sites. There is considerable divergence between intracellular domains of invertebrate and vertebrate teneurins as well as between different invertebrate proteins. This domain is found in the intracellular N-terminal region of the teneurin family. Human genes Human genes encoded teneurin domain proteins (TENM1-4) are list in the infoboxes. References Further reading Protein families