The Loutre River is a tributary of the Missouri River in the United States. The Loutre River begins in Audrain County. It flows into the Missouri River from the north in Montgomery County opposite the town of Hermann. Loutre, meaning "otter", was applied to the river by French trappers. At Mineola, the river has a mean annual discharge of 98 cubic feet per second. Location Mouth Confluence with the Missouri River in Warren County, Missouri: Source Audrain County, Missouri: History The Loutre River is threaded through the area's history. It was the means of transportation and the trade route for Native Americans, early European and American settlers in early Montgomery Country. Historical evidence of human activities in and around the Loutre River date over 10,000 years. Loutre River travels through Graham Cave State Park in Montgomery County. Graham Cave is located in the hills directly above the river. When discovered, the cave helped rewrite history books. During archaeological excavation by the University of Missouri from 1949 to 1955, the cave yielded evidence of ancient Dalton and Archaic Period Native Americans. Within the cave was an ancient ceremonial location dating to 8000 B.C.E. Loutre Township comprises the southern portion of Montgomery County. The first Europeans to settle in the county were on Loutre Island perhaps as early as 1798, while the country was under control of Spain. The island was first discovered by French trappers and voyageurs. Loutre Lick was one of the earliest settlements in Montgomery County, settled between 1808 and 1810, and named because of its location near a salt lick at the river. It was also called Van Bibbers Lick, for Major Isaac Van Bibber, who migrated in 1800 from Kentucky to Missouri. Here he erected a hotel, some cabins, and stables. He tried unsuccessfully to operate a salt mill. Loutre Lick was succeeded by present-day Mineola, Missouri. Loutre Lick was probably the first mineral spring in Missouri to be developed as a kind of health resort. Here Daniel Boone and Thomas Hart Benton sought relief for their ailments. Benton bragged of the Loutre Lick spring in the halls of Congress, where Henry Clay referred to him as the "Senator from Missouri's Bethesda." Skirmishes took place between Indians and encroaching settlers. The Army established Fort Clemson on Loutre Island as a base of operations to protect American settlers. On March 7, 1815 Captain Callaway and three soldiers (James