Bona of Savoy, Duchess of Milan (10 August 1449 – 23 November 1503) was Duchess of Milan as the second spouse of Galeazzo Maria Sforza, Duke of Milan. She served as regent of Milan during the minority of her son 1476–1481. Life Born in Avigliana, Turin, Bona was a daughter of Louis, Duke of Savoy and Anne de Lusignan of Cyprus. She was one of nineteen children. Her many siblings included: Amadeus IX of Savoy, Philip II, Duke of Savoy, Louis of Savoy, Count of Geneva, Marguerite of Savoy and Charlotte of Savoy, who married King Louis XI. In 1464, Bona was to have been betrothed to Edward IV of England, until his secret marriage to Elizabeth Woodville was revealed. She showed her resentment in later years by refusing to contemplate a marriage between either of her daughters and one of Edward's sons. She married Galeazzo Maria Sforza on 9 May 1468. An alliance between the Sforza and the royal house of France had been rumoured from as early as 1460, and "in June 1464 Bona of Savoy was officially offered to Galeazzo by letters from the King of France and the Duke of Savoy". Bona's husband was assassinated, on 26 December 1476 at the age of 32 by three young noblemen on the porch of the cathedral church of San Stefano in Milan. Galeazzo was succeeded after his 10-year reign by his 7-year-old son Gian Galeazzo Sforza (1469–1494). Bona relied on the enlightened competence of the ducal secretary Cicco Simonetta and was proclaimed regent on 9 January 1477 in the name of her son. Her position, which was strengthened by the able Simonetta, was however contested by her brothers-in-law, eager to control the will of the young duke. These (among whom the ambitious Sforza Maria stood out) tried in May 1477 to oust Bona and Simonetta from the tutelage of Gian Galeazzo Maria, but Simonetta managed to precede and exile them (25 May). The revenge of the brothers-in-law, however, was not long in coming: helped by the leader Roberto Sanseverino, the young Sforza set up an army that invaded the Duchy, conquering Genoa and Tortona between 1478 and 1479. To facilitate their exploits was also the progressive fall from grace of Simonetta before the eyes of Bona. The latter, meanwhile, had embarked on a romantic relationship with one of her waiters from Ferrara, Antonio Tassino. It is not clear