Wetmore is an unincorporated community and a U.S. Post Office located in Custer County, Colorado, United States. Description The Wetmore post office has been in operation since 1881. The community was named after William Wetmore, a first settler. and has the ZIP Code 81253. Geography Wetmore is located at (38.237911,-105.084400). See also References External links Unincorporated communities in Custer County, Colorado Unincorporated communities in Colorado