Francis Willoughby may refer to: Francis Willoughby (1547–1596), industrialist and coalowner Francis Willoughby (1613–1671), deputy governor of Massachusetts Francis Willughby (1635–1672), English ornithologist and ichthyologist Francis Willoughby, 2nd Baron Middleton (1692–1758), Old Etonian Francis Willoughby, 3rd Baron Middleton (1726–1774), English nobleman Francis Willoughby, 5th Baron Willoughby of Parham (1605–1666), Barbadian politician