An Update From the Infectious Diseases Society of America", IDSA expressed grave concern over the weak pipeline of antibiotics to combat the growing ability of bacteria, especially the Gram-negative bacilli (GNB), to develop resistance to antibiotics. Since 2009, only 2 new antibiotics were approved in United States, and the number of new antibiotics annually approved for marketing continues to decline. The report could identify only seven antibiotics currently in phase 2 or phase 3 clinical trials to treat the GNB which includes E. coli, Salmonella, Shigella and the Enterobacteriaceae bacteria, and these drugs do not address the entire spectrum of the resistance developed by those bacteria. Some of these seven new antibiotics are combination of existent antibiotics. There are positive signs that the governments and health authorities in US and Europe have recognized the urgency of the situation. Collaborations are formed between the regulatory bodies and pharmaceutical industry with funding and added incentives. The IDSA's prognosis for sustainable R&D infrastructure for antibiotics development will depend upon clarification of FDA regulatory clinical trial guidance which would facilitate the speedy approval of new drugs, and the appropriate economic incentives for the pharmaceuticals companies to invest in this endeavor. In 2018, the IDSA put out a new statement about antibiotic research. Low financial returns on antibiotic research caused stock prices to go down, and companies had abandoned antibiotic research and development. In turn, this put pressure on the few remaining companies to deliver new antibiotics. The IDSA proposed that the government create incentives that reward and support private sector work toward a "robust, renewable antibiotic supply." Lyme disease treatment guidelines IDSA recommends against long-term antibiotic treatment for Lyme disease, arguing that it is ineffective and potentially harmful. The American Academy of Neurology, Centers for Disease Control and Prevention, National Institutes of Health, and medical groups around the world similarly recommend against such treatment. However, a minority view holds that chronic Lyme disease is responsible for a range of medically unexplained symptoms, mostly in people without any evidence of infection with Borrelia Burgdorferi, the bacterium that causes Lyme disease. Groups of patients and physicians who support the concept of chronic Lyme disease have organized to lobby for recognition of this diagnosis, as well as to argue for insurance coverage of long-term antibiotic therapy. Such groups have been critical of the IDSA guidelines on Lyme disease. In 2006, Connecticut Attorney General Richard Blumenthal announced an