Dan Joseph Stein is a South African psychiatrist who is a professor and Chair of the Dept of Psychiatry and Mental Health at the University of Cape Town, and Director of the South African MRC Unit on Risk & Resilience in Mental Disorders. Stein was the Director of UCT's early Brain and Behaviour Initiative, and was the inaugural Scientific Director of UCT's later Neuroscience Institute. He has also been a Visiting Professor at Mount Sinai School of Medicine in the United States. Education Stein studied medicine at the University of Cape Town, including an intercalated undergraduate degree with majors in biochemistry and psychology. He later trained in psychiatry, and completed a post-doctoral fellowship in the area of psychopharmacology at Columbia University. He subsequently completed doctoral degrees in clinical neuroscience and in philosophy at Stellenbosch University. Career Stein's work ranges from basic neuroscience, through clinical investigations and trials, and on to epidemiological and public mental health research. He looks at clinical practice and scientific research that integrates theoretical concepts and empirical data across these different levels, strengthening a biopsychosocial approach to mental health. Having worked for many years in South Africa, he also seeks to establish integrative approaches to improving psychiatric services, training, and research in the context of a low and-middle-income country. As Chair of the Department of Psychiatry and Mental Health at the University of Cape Town, Stein has led work to integrate and improve psychiatric services, training, and research. He also led the University of Cape Town's Brain-Behaviour Initiative, which in turn provided a foundation for its Neuroscience Institute, the first on the African continent. Soon after returning to South Africa from New York, he initiated the South African Medical Research Council (SAMRC) Unit on Anxiety & Stress Disorders. The Unit undertook basic neuroscience research on anxiety, initiated brain magnetic resonance imaging and neurogenetics research in the country, and conducted the first nationally representative community survey of mental disorders on the continent. Stein has initiated and supported collaborations with and fellowships for African scientists. The Neuro-GAP study brought together researchers from Ethiopia, Kenya, South Africa, and Uganda, to work on the genetics of schizophrenia and bipolar disorder. Stein was the founding President of the African College of Neuropsychopharmacology. Stein has been part of several international research collaborations, including work on neuroimaging (the Enhancing Neuroimaging by Meta-Analysis (ENIGMA) collaboration) and work on psychiatric epidemiology (the World Mental Health (WMH)