AEN is may refer to: Acute esophageal necrosis, a rare esophageal disorder A+E Networks, a media organization based in the United States AEN Ayiou Georgiou Vrysoullon-Acheritou, an association football club in the Agios Georgios refugee settlement in Cyprus Alliance for Europe of the Nations, a pan-European political party Alfred E. Neuman, a fictional character in MAD magazine Armenian Environmental Network Armenian Sign Language asynchronous event notification in (for example) the NC-SI electrical interface