periods. Myelofibrosis is a condition that usually comes with GPS. Diagnosis GPS is diagnosed based on clinical findings and requires demonstration of absence or marked reduction of alpha-granules by electron microscopy (EM). High serum vitamin B12 levels are common in patients diagnosed with GPS. Bone marrow sampling, though not required for diagnosis of GPS, might be necessary to evaluate myelofibrosis occurring in GPS and to exclude other disorders. Management There is no specific treatment for GPS, but it can be managed by anticipating and preventing the risks of bleeding. The treatment options include desmopressin. Splenectomy can be used to increase the platelet counts in those whose platelet counts decrease to approximately 30,000/microliter. Prognosis is generally good early in life when thrombocytopenia is mild. Epidemiology Currently, only 60 cases have been recorded worldwide. While the prevalence of this syndrome is not known, it was found that it affects males and females equally. See also Pseudo gray platelet syndrome Giant platelet disorder References External links Autosomal dominant disorders Rare syndromes Syndromes affecting blood Genetic disorders with OMIM but no gene Coagulopathies