his opponent, Tom Colonic. Reduced to janitorial duty in the bowels, Phlegmming foolishly ignores a notice not to push a button that triggers Frank's flatulence, ejecting himself from the body. Cast Voice cast Chris Rock as Osmosis "Ozzy" Jones, a quick-witted white blood cell with an impulsive personality. Laurence Fishburne as Thrax, an extremely deadly pathogenic agent. David Hyde Pierce as Special Agent Drixenol "Drix" Drixobenzometaphedramine, a by-the-book cold pill who becomes Ozzy's partner. Brandy Norwood as Leah Estrogen, Mayor Phlegmming's secretary and Ozzy's love interest. William Shatner as Mayor Phlegmming, the arrogant, incompetent and corrupt mayor of the City of Frank. Ron Howard as Tom Colonic, Phlegmming's rival for the mayoralty of the City of Frank. Twisted Brown Trucker members Kid Rock, Kenny Olsen, Jason Krause, Joe C., Stefanie Eulinberg, Jimmie "Bones" Trombly, and Uncle Kracker provide the voices of the fictional band "Kidney Rock". Joel Silver makes an uncredited appearance as the police chief. Additional voices are provided by Jonathan Adams, Carlos Alazraqui, Eddie Barth, Rodger Bumpass, Paul Christie, Antonio Fargas, Eddie Frierson, Donald Fullilove, Jackie Gonneau, Richard Steven Horvitz, Rif Hutton, Joyce Kurtz, Anne Lockhart, Sherry Lynn, Danny Mann, Mickie McGowan, "Stuttering" John Melendez, Paul Pape, Chris Phillips, Al Rodrigo, Herschel Sparber, Doug Stone, Steve Susskind, and Robert Wisdom. Live-action Bill Murray as Frank DeTorre, Shane's widowed father and Bob's brother. Molly Shannon as Mrs. Boyd, Shane's science and P.E. teacher. Chris Elliott as Bob DeTorre, Frank's brother and Shane's uncle. Elena Franklin as Shane DeTorre, Frank's 10-year-old daughter and Bob's niece. Production Osmosis Jones went through development hell during production. The animated sequences, directed by Tom Sito and Piet Kroon, went into production as planned even being completed ahead of schedule, but acquiring both a director and a star actor for the live-action sequences took a considerable amount of time, until Bill Murray was cast as the main character of Frank, and Peter and Bobby Farrelly stepped in to direct the live-action sequences. As part of their contract, the Farrelly brothers are credited as the primary directors of the film, although they did no supervision of the animated portions of the film. Will Smith was interested in the part of Ozzy, but in the end his schedule would not permit it. Principal photography on the live-action scenes took place from April 2 to June 19, 2000 in Plymouth, Massachusetts. Osmosis Jones was originally rated PG-13 by