the way in which active, living organisms responded to staining compared with nonliving organisms, he concluded that the nucleus must hold the "bioplasm", or the essence of life. He was a passionate and vocal advocate of the view that there is an essential difference between living and inert matter. He felt that there were reasons to doubt the evidence for human evolution. Beale has been described as a "staunch vitalist". He believed in a "vital force", saying, He said, Publications The Microscope, and Its Application to Clinical Medicine (1854) How to Work with the Microscope (5th ed., 1880, 1st pub. 1857) Illustrations to How to Work with the Microscope (1859) On the Scientific Investigation of Disease in Animals and Man (1865) The Microscope in its Application to Practical Medicine (1867) Protoplasm: Or, Life, Force, and Matter (1870) Disease Germs: Their Real Nature (1870) The Mystery of Life (1871) Life Theories: Their Influence Upon Religious Thought (1871) Bioplasm: An Introduction to the Study of Physiology & Medicine (1872) The Microscope in Medicine (1878) On Slight Ailments (1882) Urinary and Renal Derangements and Calculous Disorders (1885) Our Morality and the Moral Question (1893) The New Materialism: Dictatorial Scientific Utterances and the Decline of Thought (1899) Notes and references Citations Sources Further reading Gerald L. Geison. (1969). The Protoplasmic Theory of Life and the Vitalist-Mechanist Debate. Isis 60 (3): 272–292. 1828 births 1906 deaths 19th-century English medical doctors Academics of King's College London Alumni of King's College London Fellows of the Royal Microscopical Society Fellows of the Royal Society People educated at King's College School, London Medical doctors from London Vitalists