4 and wrote: "Likely to entertain kids, who seem to like jokes about anatomical plumbing. For adults, there is the exuberance of the animation and the energy of the whole movie, which is just plain clever." The use of gross-out humor in the film's live-action sequences, as seen in most films directed by the Farrelly brothers, was widely criticized. As such, Lisa Alspector of the Chicago Reader described the film as a "cathartically disgusting adventure movie". Maitland McDonagh of TV Guide praised the film's animation and its glimpse of intelligence although did criticize the humor as being "so distasteful". Lisa Schwarzbaum of Entertainment Weekly felt that the film had a diverse premise as it "oscillates between streaky black comedy and sanitary instruction"; however the scatological themes were again pointed out. Jonathan Foreman of New York Post claimed Osmosis Jones to have generic plotting, saying that "It's no funnier than your average grade-school biology lesson and less pedagogically useful than your typical Farrelly brothers comedy." Michael Sragow of Baltimore Sun praised David Hyde Pierce's performance as Drix, claiming him to be "hilarious" and "a take-charge dose of medicine". The film received numerous Annie Award nominations including Best Animated Feature (losing to Shrek). Soundtrack A soundtrack containing hip hop and R&B music was released on August 7, 2001, by Atlantic Records. The soundtrack failed to chart on the Billboard 200, but Trick Daddy's single "Take It to da House" managed to make it to number 88 on the Billboard Hot 100 singles chart. Cancelled sequel In December 2002, it was announced that an sequel titled Osmosis Jones 2, the film focused on Ozzy's daughter named Jebe. See also Once Upon a Time... Life, an animated series with similar anthropomorphic representations of cells and germs. Ozzy & Drix, an animated series that serves as a continuation of the film. Cells at Work!, a Japanese manga/anime series with a similar premise. Inner Workings, a Disney short film that is set in the human body. Inside Out, a Pixar computer-animated film that is set inside the human brain. References External links 2001 films 2001 animated films 2001 action comedy films 2001 directorial debut films 2000s buddy comedy films 2000s buddy cop films 2000s American animated films American films with live action and animation American action comedy films American buddy comedy films American buddy cop films Fictional microorganisms American dark fantasy films Films about immunity Films