Since its invention by John Stith Pemberton in 1886, criticisms of Coca-Cola as a product, and of the business practices of The Coca-Cola Company have been significant. The Coca-Cola Company is the largest soft drink company in the world, distributing over 500 different products. Since the early 2000s, the criticism of the use of Coca-Cola products, as well as the company itself, escalated, with criticism leveled at the company over health effects, environmental issues, animal testing, economic business practices and employee issues. The Coca-Cola Company has been faced with multiple lawsuits concerning the various criticisms. Coca-Cola’s first trial In 1909, the Pure Food and Drug Act passed, and the United States government seized 40 barrels and 20 kegs of Coca-Cola syrup because they considered the added caffeine to be a harmful ingredient. One of the first noted criticisms of Coca-Cola was that it produced serious mental and motor deficits. This resulted in Coca-Cola's first lawsuit and trial where the official charges were that Coca-Cola was adulterated and misbranded. The trial following the lawsuit, The United States Government v. Forty Barrels, Twenty Kegs Coca-Cola, started in March 1911 a year and a half after the government had seized the barrels and kegs. Harvey Washington Wiley, a chemist and head of the Bureau of Chemistry in the U.S. Department of Agriculture led the lawsuit. Wiley was anti Coca-Cola mainly because he was against the added caffeine. The trial included many studies as well as paid testimonies from both parties and in the end was dismissed by the judge. However, the United States government ended up winning the case when they took it to the Supreme Court in 1916. This resulted in the reduction of caffeine content in Coca-Cola. Products Caffeine In 1916, there was a federal suit under which the US government unsuccessfully attempted to force The Coca-Cola Company to remove caffeine from its products. Bottles In 1944, a waitress named Escola was putting away glass bottles of Coca-Cola when one of the bottles spontaneously exploded in her hand. She successfully sued the company, claiming they were liable. Health effects Coca-Cola is rich in sugar, especially sucrose, which causes dental caries when consumed regularly. Besides this, the high caloric value contributes to obesity. Both are major health issues in the developed world. According to the Harvard School of Public Health in 2015, "...people who drink 1–2 cans of sugary beverages daily are