Holt-Oram syndrome may need various treatments, depending on how the syndrome manifests. Surgery, prosthetics and physical or occupational therapy can help people with bone abnormalities. Heart defects may call for surgery, medication, pacemakers or close monitoring. Pregnant women with Holt-Oram syndrome and heart abnormalities should be followed by a cardiologist during pregnancy. History It is named for Mary Holt and Samuel Oram, who published a paper on it in 1960. See also Absent radius Heart-hand diseases References Further reading GeneReview/NIH/UW entry on Holt-Oram Syndrome External links Syndromes affecting the heart Autosomal dominant disorders Transcription factor deficiencies Congenital disorders Syndromes with dysmelia Rare syndromes