Allergies to cats are one of the most common allergies among human individuals. Among the eight known cat allergens, the most prominent allergen is secretoglobin Fel d 1, which is produced in the anal glands, salivary glands, and, mainly, in sebaceous glands of cats, and is ubiquitous in the United States, even in households without cats. Allergic symptoms associated with cats include coughing, wheezing, chest tightening, itching, nasal congestion, rash, watery eyes, sneezing, chapped lips, and similar symptoms. In worst-case scenarios, allergies to cats can develop into more life-threatening conditions such as rhinitis and mild to severe forms of asthma. Despite these symptoms, there are many types of solutions to mitigate the allergic effects of cats, including medications, vaccines, and home remedies. Hypoallergenic cats are another solution for individuals who want pets without the allergic consequences. Furthermore, prospective pet owners can reduce allergic reactions by selecting female cats, which are associated with a lower production of allergens. Cat allergens Eight cat allergens have been recognized by the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub‐Committee. Fel d 1 is the most prominent cat allergen, accounting for 96% of human cat allergies. The remaining cat allergens are Fel d 2–8, with Fel d 4, a major urinary protein found in the saliva of cats, occurring the most in humans among the other seven allergens. All cats produce Fel d 1, including hypoallergenic cats. The main method of transmission is through a cat's saliva or dander, which adheres to clothing. A study found that 63% of people allergic to cats have antibodies against Fel d 4. Fel d 1 Fel d 1 is the most dominant cat allergen. It is part of the secretoglobulin family, which are proteins found only in mammals and birds. Fel d 1 is primarily secreted through the sebaceous glands and can be found on the skin and fur of a cat. It is less commonly secreted through the salivary gland, lacrimal glands, and skin and anal glands. Fel d 4 and Fel d 7 Fel d 4 and Fel d 7 are cat lipocalins. Fel d 4 and Fel d 7 are two of the most common cat allergens after Fel d 1. Fel d 4 is produced in the submandibular salivary glands and is secreted in the saliva of cats, via which it is deposited on to cat dander during grooming, and is