New York State Route 290 (NY 290) is a state highway located entirely within Onondaga County, New York, extending from downtown Syracuse to the east side of the county. It provides access to Green Lakes State Park from the north. NY 290 is one of several state highways linking Syracuse and its eastern suburbs. Route description NY 290 begins at an intersection with US 11 (North State Street) in the shadows of I-81 and I-690 in downtown Syracuse. NY 290 proceeds northeast along James Street, a four-lane commercial street through downtown Syracuse, crossing through the Near Northeast neighborhood. Passing numerous apartment buildings and residential complexes, the route continues past multiple commercial businesses before crossing into the Sedgwick neighborhood. NY 290 continues along James Street, now a four-lane residential street in a less dense section of Syracuse. Crossing Teall Avenue, the southern continuation of County Route 228 (CR 228), the route enters the Eastwood neighborhood of Syracuse. In Eastwood, NY 290 continues northeast along James Street until reaching Shotwell Park, where it junctions with Grant Boulevard. At this junction, NY 290 turns eastward along James Street, becoming a two-lane commercial street. Several blocks to the east of Grant, NY 290 reaches a junction with NY 598 (Midler Avenue). Continuing through Eastwood, the route expands to four lanes near the local water tower and crosses into the town of De Witt, where it junctions with NY 635 (Thompson Road) above railroad tracks. NY 290 continues eastward through De Witt, becoming a four-lane boulevard through the town, reaching a fork with West Manlius Street, where James Street continues east as CR 53A and NY 290 turns southeast on West Manlius. Back to two lanes, NY 290 proceeds southeast along West Manlius Street, a residential street through De Witt before crossing into the village of East Syracuse. At the junction with Burnet Street, NY 290 enters the center of East Syracuse, becoming a two-lane commercial street, changing to East Manlius Street at North Center Street. Two blocks east of this junction, NY 290 reaches a junction with Bridge Street, where East Manlius continues towards CR 77, while NY 290 turns southeast on Bridge. Crossing over tracks used by CSX Transportation by its Mohawk Subdivision, NY 290 reaches a junction with Bridge Street and Manlius Center Road, where NY 290 turns northeast along Manlius Center. Now a six-lane arterial, NY 290 proceeds northeast through East