2004, pitching in six games for the Indians. In 2005, Guthrie spent the majority of the season in the minors. He appeared in one game for the Indians, pitching six innings while allowing four runs. Guthrie spent most of the 2006 season with the Triple-A Buffalo Bisons, but was twice called up to the MLB to join the Cleveland Indians as a relief pitcher. He wore jersey number 57 for both the Bisons and the Indians. After being removed from the 40-man roster following the signing of Trot Nixon and with no remaining Minor League options, he was designated for assignment on January 19, 2007. Baltimore Orioles Guthrie was claimed off waivers by the Baltimore Orioles on January 29, 2007. Upon joining the team, he requested and was granted permission to wear uniform number 46 from then-executive vice president of baseball operations Mike Flanagan, who had worn it during his playing career with the ballclub. After starting the year in the Baltimore Orioles' bullpen and then moving into the starting rotation, Guthrie enjoyed a breakout year in 2007, becoming one of the best and most consistent pitchers in the American League. Through June 21 that year, he ranked second in ERA and allowed more than two earned runs in just one out of 10 starts. He was also first in the AL in WHIP. Through the end of July 2007, Guthrie had a 7–3 record in 17 starts to go with a sparkling 2.89 ERA and a 1.027 WHIP (second only to two-time Cy Young Award winner Johan Santana) albeit only in 124.7 innings of work. Guthrie's rise to unexpected success in the first half of the season led to consideration for the American League's Rookie of the Year Award. He finished the year 7–5 with a 3.70 ERA in 32 games (26 starts). In August 2008, Guthrie recorded his first career complete game, defeating the Seattle Mariners 3–1. Throughout the 2008 season, Guthrie emerged as the staff ace of the Baltimore Orioles. Guthrie finished the season with a 3.63 ERA, going 10–12 in 30 starts for the Orioles. Guthrie pitched for Team USA in the 2009 World Baseball Classic. Guthrie pitched on Opening Day for the Orioles against the New York Yankees, with 48,607 people in attendance at Camden Yards. Guthrie pitched six innings and gave up three runs in that game. The 2009 season wasn't Guthrie's best, as