The Re-Mission games for young cancer patients were conceived by Pam Omidyar and designed based research by the nonprofit HopeLab Foundation, with direct input from young cancer patients and oncology doctors and nurses, and game developer Realtime Associates, among others. The games engage young cancer patients through entertaining game play while impacting specific psychological and behavioral outcomes associated with successful cancer treatment. HopeLab has made Re-Mission games available at no charge to young people with cancer and their families, as well as oncology healthcare workers and institutions around the world. Re-Mission The original Re-Mission game was released in 2006 as a Microsoft Windows based third-person shooter based in the serious games genre. In Re-Mission, the player controls an RX5-E ("Roxxi") nanobot who is designed to be injected into the human body and fight particular types of cancer and related infections such as non-Hodgkin lymphoma and leukemia, at a cellular level. The player must also monitor patient health and report any symptoms back to Dr. West (the in-game doctor and project leader). Each of the 20 levels is designed to inform the patient on a variety of treatments, how they function, and the importance of maintaining strict adherence to those treatments. Various "weapons" are used, such as the Chemoblaster, Radiation Gun, and antibiotic rocket. Copies of Re-Mission were distributed at no charge to others, though donations were accepted. As of 2012, more than 200,000 copies of Re-Mission had been distributed in 81 countries, placing it among the most successful serious games to date. HopeLab engaged organizations and individuals worldwide to facilitate distribution of the game to teens and young adults with cancer. On May 30, 2007, Cigna HealthCare announced a partnership with HopeLab in which Cigna distributes copies of Re-Mission to its members at no cost. HopeLab has also partnered with Starlight Children's Foundation and the ESA Foundation to distribute Re-Mission. Re-Mission 2 Re-Mission 2 is the 2013 follow-up to the original game. A collection of free online games, Re-Mission 2 is designed to improve psychological and behavioral outcomes associated with cancer treatment adherence. Each game puts players inside the body to fight cancer with weapons like chemotherapy, antibiotics and the body's natural defenses. Game play parallels real-world strategies used to fight cancer and win. More than 120 young people with cancer participated in the research and development of the games. Re-Mission 2 applies insights from a brain-imaging study published in