marijuana use lowers testosterone levels and other reproductive hormones, causing erectile dysfunction in males. Alcohol Alcohol inhibits neuronal excitability through acting on gamma-aminobutyric acid (GABA) receptors. Alcohol is often accessible in a number of social situations across many cultures and is frequently connected with uninhibited social activities. Alcohol has been shown in human research to have surprising effects on the human libido. While some studies indicates that alcohol improves sexual behavior and desire, other research indicates that alcohol impairs sexual function. The conditions under which the drinking occurs, laboratory research vs self-report studies from users, as well as the amounts of alcohol consumed, may all contribute to these controversial outcomes. Laboratory studies have demonstrated that while low blood alcohol levels have no effect on or slightly enhance sexual arousal and responsiveness in men, elevated blood alcohol levels result in decreased erectile responsiveness, decreased arousal, and impaired ability to ejaculate. Other laboratory research, on the other hand, found no significant influence of either low or high blood alcohol levels on measures of arousal. Even with mild alcohol use, women have decreased vaginal flow responses. In apparent contrast, women self-report heightened sexual desire and pleasure when they consume more alcohol and are more likely to engage in sexual activities with someone when intoxicated. Heavy alcohol intake impairs sexual and reproductive function, erectile, and ejaculatory dysfunction in males, and sexual arousal, interest, and orgasm in women. Alcohol and sex although alcohol may have varying impacts on sexual performance depending on the amount drank, it generally impairs sexual functioning and contributes to increased sexual risk taking. Cocaine Cocaine is a potent psycho-stimulant that boosts dopamine levels by inhibiting dopamine transporters. It has been often linked to enhanced libido and risk-taking behavior in humans. Cocaine has been observed to increase sexual arousal or to trigger spontaneous erections and orgasms. In contrast, other data has shown that persistent cocaine use impairs sexual desire and the capacity of both men and females to achieve orgasm. MDMA MDMA or "ecstasy" originally gained popularity in the 1980s among college students. According to a survey conducted, 10% of college students at a big US institution reported using MDMA, with alcohol and marijuana being the most often used substances. MDMA users report increased enjoyment in physical contact and proximity rather than a sexual experience. MDMA has been shown to impair sexual performance, including erectile dysfunction and delayed orgasm, as well as