round she defeated Jill Craybas to advance to third round at the US Open for the first time. There she faced fellow Russian and her former doubles partner Vera Zvonareva where she fell. Vesnina next played at the Pan Pacific Open where she was unseeded in singles. She beat María José Martínez Sánchez in the first round and Roberta Vinci in the second but she had to retire in her third-round match against the seventh seed Jelena Janković due to a left thigh strain while trailing. She then played at the China Open but she lost in the first round to Melinda Czink. Vesnina then played at the Kremlin Cup where she was seeded sixth. She suffered a first-round defeat by compatriot Evgeniya Rodina. Vesnina finished the year with a 34–21 singles record and ranked world No. 24. 2010 Her first tournament of the year was the Auckland Open where she was seeded No. 6. After beating Alberta Brianti in the first, she was defeated in the second round by Alizé Cornet. She made the quarterfinals in doubles, partnering Riza Zalameda, but lost to Vladimíra Uhlířová and Renata Voráčová. At the Sydney International, she faced No. 7 Vera Zvonareva in the first round, but at 3–3 Zvonareva retired due to a right ankle injury. In the second round, she was defeated by Vera Dushevina. Seeded No. 28 at the Australian Open, Vesnina was defeated in the first round by Tathiana Garbin. In the doubles, she partnered with Zheng Jie, seeded No. 9, they beat Alizé Cornet and Sharon Fichman in the first round in two sets and in the second, they won in a walkover. In the third round, they lost to the eighth-seeds Bethanie Mattek-Sands and Yan Zi. Vesnina also entered mixed doubles with Andy Ram as the No. 8 seeds. In the first round, they defeated Alicia Molik and Matthew Ebden, and in the second Anna-Lena Grönefeld and Christopher Kas but then fell to the top-seeded Cara Black and Leander Paes in the quarterfinals. Her next tournament was the Paris indoor event where she was knocked out in the second round again by Tathiana Garbin. At the Dubai Championships, Vesnina fell in three sets to world No. 14, Vera Zvonareva, in the first round. At the Amelia Island Championships, she made it to the semifinals losing to world No. 2, Caroline Wozniacki. She then lost seven consecutive matches,