infrastructure-related software applications and databases of MDL, including CrossFire Beilstein, CrossFire Gmelin, the Patent Chemistry Database, xPharm and PharmaPendium — were retained by Elsevier and integrated within Elsevier's Science & Technology operations. The August 2007 press release announcing Symyx Technologies' acquisition of MDL indicates that combining Symyx and MDL offerings creates an expanded set of software solutions and services to enhance R&D productivity in the life sciences, chemicals and energy industries. The press release states: "With this solution set, Symyx will be able to accelerate its customers' move toward paperless labs by integrating content, collaborative desktops, automation and information management for users, workgroups and the enterprise." Innovations Commercial system for interactive molecular modeling (PRXBLD, 1979) Commercial system for computer handling of chemical reactions (REACCS, 1982) Commercial system integrating chemical structures with data (MACCS-II, 1984) PC-based chemistry database system, the Chemist's Personal Software Series (CPSS: ChemBase, ChemTalk/ChemHost, 1985) Commercial system integrating chemistry drawing and word processing (ChemText, 1986) Commercial 3D structure database (MACCS-3D, 1988) Commercial system for storing structures of mixtures and formulations (MACCS-II Substance Module, 1989) Commercial client-server system for managing chemical and biological information (MDL ISIS, 1991) Commercial system for structure-based handling of generic structures (MDL Central Library, 1996) Searchable, "live" chemical structures and spectra (JCAMP-DX format) in Web pages (MDL Chime plug-in, MDL Chemscape server, 1996/1997) Commercial system dynamically linking citations to electronic journal articles and patents (MDL LitLink, 1999) Web-based commercial system indexing multiple structure databases and linking to synthetic methodology databases and major reference works (DiscoveryGate, 2002) Software application for predicting potential carcinogenic risk of compounds based on their structures ([MDL Carcinogenicity Module, 2003) Complete, open, flexible and scalable n-tier informatics system supporting enterprise-wide business process, data and application integration for the life sciences (MDL Isentris, 2004) Advanced structure drawing with All-Purpose Drawing Tool and custom template toolbars, MDL Draw, 2004) Structure-searchable patent chemistry information (Patent Chemistry Database, 2004) and online pharmacological information (xPharm, 2004) Key laboratory workflow applications (MDL Logistics reagent management application and MDL Notebook electronic laboratory notebook, 2005) Isentris-based application for building and managing compound registries (MDL Registration, 2006) First electronically searchable FDA Drug Approval Packages (PharmaPendium, 2006) Out-of-the-box Reaction Planner for exploring precursor steps, integration of proprietary and commercial data (Isentris 2.0 and 3.0, 2007). See also Computational chemistry Drug development Drug discovery Drug discovery hit to lead Bioinformatics Pre-clinical development Compound management References External links Molecular Connection 25th Anniversary Chemical companies