No. 127, Nicole Pratt, at Bangalore and to world No. 86, Viktoriya Kutuzova, at Indian Wells. However, she reached the third round at Miami and Amelia Island losing to Tatiana Golovin and Virginia Ruano Pascual, respectively. The week after, playing at Family Circle Cup, Vesnina again came out the loser this time against fellow-Russian Vera Zvonareva. In May, retreating to a lower-level Tier-IV event at Estoril, Portugal, she encountered Flavia Pennetta, the first seed in the draw, in the first round; and this time the Italian wrought her revenge. At the Berlin Open, she lost to Czech Květa Peschke in the first round. At the Internationaux de Strasbourg, Vesnina encountered fierce resistance in the first round from upcoming Italian world No. 249, Karin Knapp, but finally defeated her to book her place in the second round, where she beat world No. 27, Marion Bartoli, for the second time in her career. In the quarterfinals, clay-court expert and world No. 28, Anabel Medina Garrigues, had the better of their joust, taking it. At the French Open, she lost to Peng Shuai in the first round. Vesnina entered the grass-court circuit in Birmingham and 's-Hertogenbosch, and both reaching the second round losing to world No. 39, Mara Santangelo, and world No. 8, Elena Dementieva, respectively. In July, entering Wimbledon Championships ranked No. 63, she recovered from a set down to fend off world No. 75, María Sánchez Lorenzo, in the first round, and then second round she lost compatriot Anna Chakvetadze. At the Carlsbad Open and LA Tennis Championships, Vesnina reached the second round of both events, losing to Emma Laine and Meghann Shaughnessy, respectively. At the qualifying round of the Rogers Cup, she was upset by Neha Uberoi of the United States in the first round. The following week at Forest Hills Classic, she lost to Shaughnessy at the quarterfinal stage. In September, in her first appearance at the US Open, she lost to world No. 14, Mary Pierce, in the first round. At the China Open, in the first round, Vesnina at last wreaked revenge upon Emma Laine after a lengthy struggle, but then in the second she fell to world No. 23, Li Na. A string of three further moderate second-round finishes in successive weeks followed in the earlier part of October in Guangzhou International Open losing to veteran Israeli Tzipora Obziler, in Tashkent Open losing to Kateryna Bondarenko,