New York State Route 221 (NY 221) is a state highway in Cortland County, New York, in the United States. Its western terminus is at an intersection with NY 38 in the town of Harford. The eastern terminus is at a junction with NY 26 and NY 41 in the town of Willet. Near its western end, NY 221 intersects New York State Route 200. Together, NY 200 and NY 221 form a loop route off NY 38 between the hamlets of Harford and Harford Mills within the town of Harford. NY 221 originally followed modern NY 200 and ended at U.S. Route 11 (US 11) in Marathon when it was assigned as part of the 1930 renumbering of state highways in New York. It was extended to its present length by the following year and realigned to serve Harford later in the decade. NY 200 was assigned in the 1940s. Route description NY 221 begins at an intersection with NY 38 in the town of Harford. The route progresses northward through a small hamlet, crossing the Owego and Harford Railway and serving a mobile home park. At the intersection with Owego Hill Road, NY 221 turns eastward as a two-lane road, where the route changes backdrops into a more rural and residential mix. After about a mile, the route intersects with NY 200, a route that connects NY 221 back to NY 38 and the hamlet of Harford Mills. At this junction, NY 221 turns north once again, while NY 200 begins on the former right-of-way used by NY 221. The surroundings remain the same as the route continues, turning to the northeast, and soon east at the junction at County Route 131 (CR 131; Babcock Hollow Road). The rural road bends to the southeast gradually, entering the town of Lapeer, turning east again until it meets CR 133 (Clarks Corner Road). The highway soon reverts to a southeast direction, passing to the north of Beaver Pond and the county line, while NY 221 enters the hamlet of Hunts Corners and intersects with CR 136 (Jennings Creek Road). Here, NY 221 changes direction again, following a northeasterly path out of the hamlet. It bypasses the nearby hamlet of Clarks Corner and soon intersects with the eastern terminus of CR 133, which gives way to NY 221 as the state road merges with the east–west county highway. NY 221 continues