week, Vesnina won through qualifying into a WTA Tour main draw for the fourth time at Palermo but lost Maret Ani in the first round. In her next three events, she failed to qualify for the main draw of the WTA events at the Nordic Light Open losing to Emma Laine in the third round of the qualifying draw, in the Rogers Cup where she first beat Swiss perennial and world No. 110, Emmanuelle Gagliardi, but then was ousted by world No. 93, Rika Fujiwara, and in the US Open to Marina Erakovic in the second round of the qualifying draw. She then reached the semifinals in Denain, France, losing to Arantxa Parra Santonja, and in Bordeaux losing to Stéphanie Foretz. Vesnina attained direct entry to a main draw for the first time in her career in October at the Tashkent Open, where she reached her first quarterfinals losing to Akgul Amanmuradova. She then failed to qualify at the Kremlin Cup losing to Alona Bondarenko. In the Generali Ladies Linz, she came through the qualifying round before losing to Tamira Paszek. In November at the Bell Challenge, Vesnina reached her second quarterfinal losing to 75th-ranked Sofia Arvidsson. In the next two weeks, she came unstuck in early rounds of ITF events, losing to Emma Laine in the first round at Pittsburgh, Philadelphia, and to Kaia Kanepi in the second round at Deauville, France. She ended the year with a semifinal appearance at Poitiers in the final week of November and her last tournament, losing to Viktoriya Kutuzova (en route she beat Marion Bartoli and world No. 96, Stéphanie Foretz). She ended the year ranked No. 111. 2006 Beginning the new season at the Brisbane International, Vesnina was defeated by Puerto Rican world No. 157, Vilmarie Castellvi, in the first round of the qualifying draw for the Tier III event at Gold Coast, and then she was beaten by Nuria Llagostera Vives in the first round of the Hobart International the following week. Being ranked No. 100, she was awarded direct entry into her first ever Grand Slam tournament at the Australian Open, and reached the fourth round with defeats of qualifiers Li Ting, Julia Schruff and Olga Savchuk before losing to world No. 7, Nadia Petrova. She next competed at the Bangalore Open and Indian Wells Open but lost in the first rounds of both contests, losing to Australian world