of DNA, the nucleosome, and continues with the focus on understanding the higher orders of folding DNA. Neurobiology A new division of Neurobiology was created in 1993 with a wide variety of topics. Nigel Unwin has further developed electron crystallography and solved the structure of the acetylcholine receptor, which activates many neurons. Michel Goedert has identified variant proteins associated with Alzheimer's disease. Instrumentation Scientific advances often depend on technological advances: the LMB has been at the forefront of many of these. Some major examples include nucleic acid sequencing, protein and antibody engineering, construction of new X-ray equipment and the invention of the scanning confocal microscope. Administrative structure The LMB has a deliberately simple administrative environment. From outside the LMB, the parent MRC ensured that the quinquennial assessment had a light touch: only a brief explanation of past achievements and an indication of where future plans lay were required by the external committee. Their recommendations were simply advisory, leaving the division leaders a free hand as to how to run their affairs: they were assumed to know best. Within the LMB, Perutz's criterion of how to arrange things was that the act of doing science should be facilitated at all levels. The LMB had a single budget: there were no personal budgets or equipment — everything was communal. It had state-of-the-art equipment and was well financed by the MRC. Chemical reagents, glassware and other expendables could be withdrawn from a single store with only a signature required. Key to the smooth functioning of the lab was Michael Fuller, who was responsible for its day-to-day running. There was no overt hierarchy; everyone was on first-name terms. Most members of the lab met freely in the canteen, which was said to assist inter-divisional communication and collaboration. Today the LMB has around 450 scientists, of whom 130 are postdoctoral researchers and 110 students. The new building (situated on the Cambridge Biomedical Campus) was opened in 2013 and has four seminar rooms named after LMB scientists: Sydney Brenner, Aaron Klug, César Milstein and Frederick Sanger, as well as a lecture theatre named after the late Max Perutz. Groups at the LMB there are around fifty group leaders Groups are part of one of the four divisions of the LMB: Cell Biology, Neurobiology, Protein and Nucleic Acid Chemistry and Structural Studies. group leaders include the following people: Emeritus The LMB is also home to a number