PDZ domain, which mediates interactions between HOMER and type 5 metabotropic glutamate receptor (mGluR5). The single GLGF repeat on HOMER binds amino acids on the C-terminus of mGluR5. HOMER expression is measured at high levels during embryologic stages in rats, suggesting an important developmental function. Human PDZ proteins There are roughly 260 PDZ domains in humans. Several proteins contain multiple PDZ domains, so the number of unique PDZ-containing proteins is closer to 180. In the table below are some of the better studied members of this family: The table below contains all known PDZ proteins in humans (alphabetical): There is currently one known virus containing PDZ domains: References Further reading External links The PDZ Domain as a Complex Adaptive System A concise technical summary and a statement of principal findings and ramifications of the PDZ Domain as a Complex Adaptive System NCBI conserved domains entry https://www.pdznet.eu - An EU project to advance our understanding of the cellular signaling pathways and therapeutic potential of proteins comprising PDZ domains in healthy and pathological conditions such as cancer and neurological diseases. Protein domains Membrane proteins