as chelating agents. Two thiazolium molecules, PTB (N-phenacylthiazolium bromide) and ALT-711, have demonstrated success at reducing glucosepane levels in rats. ECM turnover A completely different approach to reducing cross-links that has been proposed is enhancing the ECM turnover processes, which would force the degradation of cross-linked proteins to replace them with new. However, a potential downside to this would be leaky blood vessels resulting from too far enhanced turnover. See also Glycation Glycosylation Advanced glycation end product Maillard Reaction References Post-translational modification