U.S. Route 45W (US 45W) is a United States Numbered Highway in West Tennessee, connecting Jackson with South Fulton via Humboldt, Trenton, Rutherford, and Union City. For the majority of its length, it runs concurrently with unsigned State Route 5 (SR 5). Route description US 45W begins in Madison County, concurrent with unsigned SR 5, in Three way at an interchange between US 45 (SR 5) and US 45E (SR 43). The highway goes as a 4-lane divided highway to cross into Gibson County and enter Humboldt, where they come to an intersection with unsigned SR 366. Here, SR 5 follows US 45W Business through while US 45W bypasses downtown to the west and north along SR 366, where it has intersections SR 152 and US 70A/US 79/SR 76. US 45W and SR 5 then rejoin at an intersection with US 70A Bypass/US 79 Bypass, and they leave Humboldt head north through farmland. US 45W/SR 5 then pass through Fruitland, where it has an intersection with SR 420 before passing through rural areas. It then enters Trenton at an intersection with SR 457 and SR 367, where US 45W/SR 5 turn right to follow a 2-lane bypass of downtown on the eastern side. The highway becomes concurrent with SR 54 and an intersection with SR 186 in a business district before having an intersection with SR 77 and SR 104, where it becomes concurrent with SR 77 and crosses the North Fork of the Forked Deer River, in a more rural part of town. SR 54 then splits off before the highway curves to the west to have another intersection with SR 367. US 45W/SR 5/SR 77 then widen to a 4-lane divided highway to curve back northward and leave Trenton. They wind their way north through farmland to pass through Dyer, where it bypasses the town on its west side, to have an interchange with SR 185, where SR 77 splits off and goes west. US 45W/SR 5 continue north to pass through Rutherford, where it bypasses the town on its west side, and has an interchange with SR 105. US 45W/SR 5 then narrows to 2-lanes as it has an intersection with its former alignment just before entering Kenton and crossing into Obion County. US 45W/SR 5 have a short concurrency with SR 89 before leaving Kenton and continuing north. The highway passes through a wooded area to