U.S. Route 45E (US 45E) is a state highway in West Tennessee, connecting Jackson with South Fulton via Milan and Martin. For the majority of its length, it runs concurrently with unsigned State Route 43 (SR 43) for most of that highway’s length except for short segments at Martin and South Fulton, where it is cosigned with SR 216 and SR 215, respectively. Route description US 45E begins in Madison County, running concurrently with unsigned SR 43 and SR 186 in Three Way at an interchange between US 45 and US 45W (SR 5). It goes northeast as a four-lane divided highway, where SR 186 splits off, before crossing into Gibson County. US 45E/SR 43 immediately enters Medina, where the highway bypasses downtown on the western side and has an intersection with SR 152. It then leaves Medina and continues north to enter Milan and has an intersection with SR 187 before becoming an undivided four-lane highway as it passes through residential areas. US 45E/SR 43 then enters downtown and runs concurrently with SR 104. The highway then has an intersection with US 70A/US 79/SR 76/SR 77, where SR 77 joins the concurrency, before continuing north through downtown to an intersection with Front Street, where SR 77 and SR 104 split off to the west. US 45E/SR 43 continues north through residential areas to have an intersection with SR 425 before leaving Milan and continuing north through rural areas, where it becomes a divided highway again. US 45E/SR 43 crosses a bridge over the Rutherford Fork of the Obion River before passing through Idlewild and Bradford, where it bypasses downtown to the west, runs concurrently with SR 54 and has an intersection with SR 105. The highway then crosses the South Fork of the Obion River to enter Weakley County. US 45E/SR 43/SR 54 then becomes an undivided highway again and enters Greenfield, where it goes straight through downtown, having an intersection with SR 124 and SR 54 splitting off and going east along Broad Street. US 45E/SR 43 the leaves town and has an intersection with SR 445 before leaving Greenfield. The highway continues north through rural areas, becoming a divided highway again to cross the Middle Fork of the Obion River, before passing through Sharon, which it bypasses completely along its west side and has an interchange with SR 89. US 45E/SR 43 then enters Martin and comes