Later, when Iron Fist broke up with her, Misty began a short romance with Power Man. This episode was a source of tension between Power Man and Iron Fist for a brief period. Misty later learned of Iron Fist's apparent demise. Iron Fist was presumed dead for an extended period until Misty saw the Super-Skrull impersonate Danny Rand (Iron Fist) on television. She confronted the Super-Skrull in his guise as Danny Rand. Misty assisted Namor in finding and saving the hero. They went to the Savage Land, where they learned that the Super-Skrull had been posing as Iron Fist, and Misty aided Namor and Namorita against the Super-Skrull. She and Danny Rand were ultimately reunited and renewed their relationship. During the 2006 "Civil War" storyline, Misty Knight and Colleen Wing were contacted by Iron Man, Reed Richards, and Spider-Man to re-form Heroes for Hire and track down superhumans who refused to register. Initially hesitant, the pair eventually agree creating a team including Shang-Chi, Humbug, Orka, Black Cat, Paladin, and a new Tarantula. Misty was identified as one of the 142 registered superheroes who was part of the Initiative. After the Civil War between the superheroes ended, Iron Fist was shocked to find that Misty had sided with the Initiative as he had joined the New Avengers. Nevertheless when the Steel Serpent and HYDRA plotted to kill Iron Fist and destroy the seven cities of heaven (the latter unbeknownst to Steel Serpent), Misty and Colleen rushed with Luke Cage to Danny's aid. Later, the three helped Danny stop a terrorist attack by HYDRA on the mystical city of K'un L'un where Danny told Misty, "I love you, Misty... but I make a lousy boyfriend". Though Danny said this, they continued a sexual relationship and finally committed to each other on his birthday, despite their disagreement over the Superhuman Registration Act. Returning from a mission to capture Moon-Boy during the World War Hulk storyline, Heroes for Hire arrive in New York to see that it has been taken over by the Hulk. After being captured by Warbound, Colleen Wing and Tarantula were offered to No-Name the Brood Queen by their possessed teammate Humbug. Misty makes a deal with Paladin to take Moon-Boy (whom Colleen had become attached to) to find both Colleen and Tarantula after their capture. When Misty and the other heroes come to save them, Colleen is in traumatic shock