The Little Muddy River is a tributary of the Big Muddy River in Illinois. It forms the boundary between Franklin and Perry counties. Cities and counties The following cities and towns are drained by the Little Muddy: Ashley DuQuoin Radom The following counties are partly in the Little Muddy watershed: Franklin County Jackson County Jefferson County Perry County Washington County See also List of Illinois rivers References Rivers of Illinois Rivers of Franklin County, Illinois Rivers of Perry County, Illinois