James Lind recognized hydrocarbonate to effectively treat lung inflammation; delivery of carbon monoxide via inhalation protocol or carbon monoxide-releasing molecules has significant preclinical data indicating an effective treatment for inflammation. The pioneering work of exploratory medicinal application of hydrocarbonate is an important origin for modern drug development. James Watt suggested hydrocarbonate could act as "an antidote to the oxygen in blood" in 1794 and cautioned about the toxicity of an overdose prior to the discoveries of carbon monoxide (1800) and hemoglobin (1840). Despite Watt's observation, it is widely accepted that Claude Bernard had first described the mechanism for carbon monoxide poisoning by describing carbon monoxide's affinity for hemoglobin displacing oxygen to induce asphyxia circa 1857. Lowe's gas process In 1873, Thaddeus S. C. Lowe developed and patented the water gas process by which large amounts of hydrogen gas could be generated for residential and commercial use in heating and lighting. This gas provided a more efficient heating fuel than the common coal gas, or coke gas, which was used in municipal service. The process used the water-gas shift reaction: The process was discovered by passing high-pressure steam over hot coal, the major source of coke gas. Lowe's process improved upon the chimney systems by which the coal could remain superheated, thereby maintaining a consistently high supply of the gas. The reaction produced carbon dioxide and hydrogen, which, after a process of cooling and "scrubbing", produced hydrogen gas. The process spurred on the industry of gas manufacturing, and gasification plants were established quickly along the Eastern seaboard of the United States. Similar processes, like the Haber–Bosch process, led to the manufacture of ammonia (NH3) by the combining of nitrogen, found in air, with hydrogen. This spurred on the refrigeration industry, which long used ammonia as its refrigerant. Prof. Lowe also held several patents on artificial ice making machines and was able to run successful businesses in cold storage, as well as products which operated on hydrogen gas. Variations Carburetted water gas Water gas has a lower heat of combustion than coal gas, so the calorific value was often boosted by passing the gas through a heated retort, into which oil was sprayed. The resulting mixed gas was called carburetted water gas. The average composition of carburated water gas is as follows: H=34-38%; CO=23-28%; saturated hydrocarbon=17-21%; unsaturated hydrocarbon=13-16%; CO=0.2-2.2%; N=2.5-5.0%. It is used as a source of heat since it has a