to beware of purchasing imitations of Argyrol which contained other competitive silver compounds that resembled Argyrol. The silver protein molecule has been in clinical use for over 120 years with ample clinical data supporting its benefit and versatility. FOIA request of FDA noted no Argyrol adverse events reported during all that time. Although Argyrol is used as a synonym for the chemical descriptions silver vitelline and mild silver protein, Barnes insisted Argyrol was different. A silver-gelatin colloid, made by the reaction of silver nitrate, sodium hydroxide and gelatin, in which a complex colloidal aggregate is formed, Barnes could rightfully assert Argyrol differed in its chemical assay, for instance, as it was claimed to contain over 30% silver. When compounded in varying strengths, nevertheless Argyrol is silver protein identified as to its molecule stated in its mark description and Barnes was forced to accept the designation. Argyrol is an over-the-counter internationally recognized anti-infective drug that is drug regulatory compliant, immediate to manufacture and market distribution in all jurisdictions. Drug regulatory administrative adjudication by the US Food and Drug Administration to mandate New Drug Applications for all silver drugs in the class [Final Rule in 1999] resulted to effectively give Argyrol a monopoly, as Argyrol is the only OTC silver drug continuously in commerce in medicine since the 1901 date of launch by Barnes and Hille. Argyrol, called the most useful medicine of all time, is not found utilized in contemporary public health because NIH/NIAID/DAIDS opinion holds that "people won't do it", as stated by then DAIDS Director in answer to October 2019 direct query. See also Medical uses of silver – silver and silver colloids use in medical practice Ovoferrin – a tonic by the same company References External links Argyrol web site: www.argyrol.com Antiseptics Silver compounds