a research initiative led by Peter Doyle and John Naylor of Beecham, in consort with Bristol-Myers. Members of the isoxazolyl penicillin family, which includes cloxacillin, dicloxacillin, and oxacillin, were synthesized to counter the increasing prevalence of infections caused by penicillin-resistant Staphylococcus aureus. While methicillin could only be administered via injection, the isoxazolyl penicillins, including oxacillin, could be given orally or by injection. Following the synthesis of cloxacillin and oxacillin, Beecham retained the right to commercially develop cloxacillin in the United Kingdom while Bristol-Myers was given the marketing rights for oxacillin in the United States. Society and Culture FDA Approval History April 8, 1971: Oxacillin Sodium Injectable Applicant: Sandoz July 27, 1973: Bactocill Capsule Applicant: GlaxoSmithKline March 10, 1980: Oxacillin Sodium Capsule Applicant: Ani Pharms Inc May 15, 1980: Oxacillin Sodium for Solution Applicant: TEVA June 2, 1981: Bactocill for Solution Applicant: GlaxoSmithKline December 23, 1986: Oxacillin Sodium Powder Applicant: Sandoz September 29, 1988: Oxacillin Sodium Injectable Applicant: Watson Labs Inc October 26, 1988: Oxacillin Sodium Injectable Applicant: Watson Labs Inc October 26, 1989: Bactocill in Plastic Container Injectable Applicant: Baxter Healthcare March 30, 2012: Oxacillin Sodium Injectable Applicant: Sagent Pharms January 18, 2013: Oxacillin Sodium Injectable Applicant: Aurobindo Pharma LTD August 25, 2014: Oxacillin Sodium Injectable Applicant: Mylan Labs LTD December 11, 2015: Oxacillin Sodium Injectable Applicant: Hospira Inc July 31, 2017: Oxacillin Sodium Injectable Applicant: Wockhardt Bio/Ag Pricing The average wholesale price (AWP) for oxacillin products are provided as follows. The prices listed below are intended to serve as reference values and do not represent the pricing determined by any single manufacturer or entity. Bactocill in Dextrose Intravenous 1 g/50 mL: $20.37 2 g/50 mL: $32.48 Oxacillin Sodium Injection 1 g: $17.52 2 g: $33.99 10 g: $138.77 References ChemBank Penicillins Enantiopure drugs Isoxazoles