The Calcutta Chromosome is a 1995 English-language novel by Indian author Amitav Ghosh. The book, set in Calcutta and New York City at some unspecified time in the future, is a medical thriller that dramatizes the adventures of people who are brought together by a mysterious turn of events. The book is loosely based on the life and times of Sir Ronald Ross, the Nobel Prize–winning scientist who achieved a breakthrough in malaria research in 1898. The novel was the recipient of the Arthur C. Clarke Award in 1997. Ghosh employs a factual background for the invented events in the novel, drawing upon Ross' Memoirs which were published in 1923. Plot summary The novel begins with the story of Antar, a resident of the future New York doing data processing for the International Water Council. A chance bit of data causes Antar to recall a bizarre encounter he had with L. Murugan, an employee of the LifeWatch organization (Antar's former employer), who disappeared in Calcutta in 1995. Murugan had asked to be transferred to Calcutta because of his fascination with the life of Sir Ronald Ross. While Antar tries to track Murugan’s movements in Calcutta through the digitized archives, another narrative thread follows Murugan directly as his path brings him into contact with a variety of other characters, some more savory than others. The plot is quite complex and its timelines are deliberately mixed up, switching from Antar's time to Murugan's to Ross' and back over the course of as many chapters. Through his research into old and lost documents and phone messages, Antar determines that Murugan had systematically unearthed a deep secret lurking behind Ross' malaria research — an underground scientific and mystical movement that could grant eternal life. Loosely described, the process of securing this form of immortality is as follows: the disciples of this movement can transfer their chromosomes into another's body, and gradually become that person or take over that person. In the novel, Ronald Ross did not discover the mysteries of the malaria parasite; it was a group of underground practitioners of a different, mystical "science," natives of India, who helped to guide Ross to the conclusions for which he is famous. These native Indians provided Ross with clues in the belief that in the moment Ross made his discovery, the parasite would change its nature. At this point, a new variant of malaria would