childless Charles II, the second grandson of Louis XIV of France was named as his successor, to preclude the union of the thrones of France and Spain. The prince, then Duke of Anjou, became Philip V of Spain. Permanent separation of the French and Spanish thrones was secured when France and Spain ratified Philip's renunciation, for himself and his descendants, of the French throne in the Treaty of Utrecht in 1714, and similar arrangements later kept the Spanish throne separate from those of the Two Sicilies and Parma. The Spanish House of Bourbon (rendered in Spanish as Borbón ) has been overthrown and restored several times, reigning 1700–1808, 1813–1868, 1875–1931, and since 1975. Bourbons ruled in Naples from 1734 to 1806 and in Sicily from 1735 to 1816, and in a unified Kingdom of the Two Sicilies from 1816 to 1860. They also ruled in Parma from 1731 to 1735, 1748–1802 and 1847–1859. Charlotte, Grand Duchess of Luxembourg (ruled 1919–1964) married a cadet of the Parmese line and thus her successors, who have ruled Luxembourg since her abdication in 1964, have also been members of the House of Bourbon. Isabel, Princess Imperial of Brazil, regent for her father, Pedro II of the Empire of Brazil, married a cadet of the Orléans line and thus their descendants, known as the Orléans-Braganza, were in the line of succession to the Brazilian throne and expected to ascend its throne had the monarchy not been abolished by a coup in 1889. All legitimate, living members of the House of Bourbon, including its cadet branches, are direct agnatic descendants of Henry IV through his son Louis XIII of France. Origins The pre-Capetian House of Bourbon was a noble family, dating at least from the beginning of the 13th century, when the estate of Bourbon was ruled by the Sire de Bourbon who was a vassal of the King of France. The term House of Bourbon ("Maison de Bourbon") is sometimes used to refer to this first house and the House of Bourbon-Dampierre, the second family to rule the seigneury. In 1272, Robert, Count of Clermont, sixth and youngest son of King Louis IX of France, married Beatrix of Bourbon, heiress to the lordship of Bourbon and member of the House of Bourbon-Dampierre. Their son Louis was made Duke of Bourbon in 1327. His descendant, the Constable of France Charles de Bourbon, was the last of