the palace, and refused her sister's request to dismiss Sarah from her household. Lady Marlborough was subsequently removed from the royal household by the Lord Chamberlain, and Anne angrily left her royal lodgings and took up residence at Syon House, the home of the Duke of Somerset. Anne was stripped of her guard of honour; courtiers were forbidden to visit her, and civic authorities were instructed to ignore her. In April, Anne gave birth to a son who died within minutes. Mary visited her, but instead of offering comfort took the opportunity to berate Anne once again for her friendship with Sarah. The sisters never saw each other again. Later that year, Anne moved to Berkeley House in Piccadilly, London, where she had a stillborn daughter in March 1693. When Mary died of smallpox in 1694, William continued to reign alone. Anne became his heir apparent, since any children he might have by another wife were assigned to a lower place in the line of succession, and the two reconciled publicly. He restored her previous honours, allowed her to reside in St James's Palace, and gave her Mary's jewels, but excluded her from government and refrained from appointing her regent during his absences abroad. Three months later, William restored Marlborough to his offices. With Anne's restoration at court, Berkeley House became a social centre for courtiers who had previously avoided contact with Anne and her husband. According to James, Anne wrote to him in 1696 requesting his permission to succeed William, and thereafter promising to restore the Crown to James's line at a convenient opportunity; he declined to give his consent. She was probably trying to ensure her own succession by attempting to prevent a direct claim by James. Act of Settlement Anne's final pregnancy ended on 25 January 1700 with a stillbirth. She had been pregnant at least 17 times over as many years, and had miscarried or given birth to stillborn children at least 12 times. Of her five liveborn children, four died before the age of two. Anne experienced bouts of "gout" (pains in her limbs and eventually stomach and head) from at least 1698. Based on her foetal losses and physical symptoms, she may have had systemic lupus erythematosus, or antiphospholipid syndrome. Alternatively, pelvic inflammatory disease could explain why the onset of her symptoms roughly coincided with her penultimate pregnancy. Other suggested causes of her failed