as his own ineffectual leadership, led to the weakening of the House of Lancaster. The Lancastrians faced a challenge from the House of York, so-called because its head, a descendant of Edward III, was Richard, Duke of York, who was at odds with the Queen. Although the Duke of York died in battle in 1460, his eldest son, Edward IV, led the Yorkists to victory in 1461, overthrowing Henry VI and Margaret of Anjou. Edward IV was constantly at odds with the Lancastrians and his own councillors after his marriage to Elizabeth Woodville, with a brief return to power for Henry VI. Edward IV prevailed, winning back the throne at Barnet and killing the Lancastrian heir, Edward of Westminster, at Tewkesbury. Afterwards he captured Margaret of Anjou, eventually sending her into exile, but not before killing Henry VI while he was held prisoner in the Tower. The Wars of the Roses, nevertheless, continued intermittently during his reign and those of his son Edward V and brother Richard III. Edward V disappeared, presumably murdered by Richard. Ultimately, the conflict culminated in success for the Lancastrian branch led by Henry Tudor, in 1485, when Richard III was killed in the Battle of Bosworth Field. King Henry VII then neutralised the remaining Yorkist forces, partly by marrying Elizabeth of York, daughter of King Edward IV and a Yorkist heir. Through skill and ability, Henry re-established absolute supremacy in the realm, and the conflicts with the nobility that had plagued previous monarchs came to an end. The reign of the second Tudor king, Henry VIII, was one of great political change. Religious upheaval and disputes with the Pope, and the fact that his marriage to Catherine of Aragon produced only one surviving child, a daughter, led the monarch to break from the Roman Catholic Church and establish the Church of England (the Anglican Church) and divorce his wife to marry Anne Boleyn. Wales – which had been conquered centuries earlier, but had remained a separate dominion – was annexed to England under the Laws in Wales Acts 1535 and 1542. Henry VIII's son and successor, the young Edward VI, continued with further religious reforms, but his early death in 1553 precipitated a succession crisis. He was wary of allowing his Catholic elder half-sister Mary I to succeed, and therefore drew up a will designating Lady Jane Grey as his heiress. Jane's reign, however, lasted