had subdued the German Protestant armies, he had failed to support the Pope's territorial ambitions for his son Pier Luigi, and relations between them cooled. The situation came to a total rupture when the imperial vice-regent, Ferrante Gonzaga, forcibly expelled Pier Luigi. In 1547 the Pope's son was assassinated at Piacenza, and Paul III placed some of the blame on the emperor. In the same year, however, and after the death of Francis I of France (1515–47) deprived the Pope of a potential ally, the stress of circumstances compelled him to accept the ecclesiastical measures in the Emperor's Interim. With reference to the assassinated prince's inheritance, the restitution of which Paul III demanded ostensibly in the name of the Church, the Pope's design was thwarted by the Emperor, who refused to surrender Piacenza, and by Pier Luigi's heir in Parma, Ottavio Farnese. In consequence of a violent altercation on this account with Cardinal Farnese, Paul III, at the age of eighty-one years, became so overwrought that an attack of sickness ensued from which he died, 10 November 1549. Paul III proved unable to suppress the Protestant Reformation, although it was during his pontificate that the foundation was laid for the Counter-Reformation. He decreed the second and final excommunication of Henry VIII of England in December 1538. His efforts in Parma led to the War of Parma two years after his death. Slavery and Sublimis Deus In May–June 1537 Paul issued the bull Sublimis Deus (also known as Unigenitus and Veritas ipsa), described by Prein (2008) as the "Magna Carta" for the human rights of the indigenous peoples of the Americas in its declaration that "the Indians were human beings and they were not to be robbed of their freedom or possessions". The subsequent implementing document Pastorale officium declared automatic excommunication for anyone who failed to abide by the new ruling. However, it met with strong opposition from the Council of The West Indies and the Crown, which declared that it violated their patronato rights, and the Pope annulled the orders the following year with the document Non Indecens Videtur. Stogre (1992) notes that Sublimis Deus is not present in Denzinger, the authoritative compendium of official Catholic teachings, and Davis (1988) asserts it was annulled due to a dispute with the Spanish crown. However, the original bull continued to circulate and be quoted by las Casas and others who supported Indian