Pope Nicholas III (; c. 1225 – 22 August 1280), born Giovanni Gaetano Orsini, was head of the Catholic Church and ruler of the Papal States from 25 November 1277 to his death on 22 August 1280. He was a Roman nobleman who had served under eight popes, been made Cardinal-Deacon of St. Nicola in Carcere Tulliano by Pope Innocent IV (1243–54), protector of the Franciscans by Pope Alexander IV (1254–61), inquisitor-general by Pope Urban IV (1261–64), and succeeded Pope John XXI (1276–77) after a six-month vacancy in the Holy See resolved in the papal election of 1277, largely through family influence. Personal life The future pope, Giovanni Gaetano Orsini, was born in Rome, a member of the prominent Orsini family of Italy, the eldest son of Roman nobleman Matteo Rosso Orsini by his first wife, Perna Caetani. His father was Lord of Vicovaro, Licenza, Bardella, Cantalupo, Roccagiovine, Galera, Fornello, Castel Sant'Angelo di Tivoli, Nettuno, Civitella, Bomarzo, San Polo and Castelfoglia, of Nerola from 1235; Lord of Mugnano, Santangelo and Monterotondo; Senator of Rome 1241–1243. His brother Giordano was named Cardinal Deacon of San Eustachio by Nicholas III on 12 March 1278. His brother Gentile became Lord of Mugnano, Penna, Nettuno and Pitigliano. Another brother, Matteo Rosso of Montegiordano, was Senator of Rome (probably) in 1279, War Captain of Todi, and Podestà of Siena in 1281. There were five other younger brothers and two sisters. The Orsini family had already produced several popes: Stephen II (752–757), Paul I (757–767) and Celestine III (1191–1198). He did not, as some scholars used to think, study at Paris—though his nephew did. His career shows no indication that he was a legal professional or a theologian. He never became a priest, until he became pope in 1277. Cardinalate Giovanni Gaetano Orsini was one of a dozen men created a cardinal by Pope Innocent IV (Sinibaldo Fieschi) in his first Consistory for the creation of cardinals, on Saturday, May 28, 1244, and was assigned the Deaconry of San Nicola in Carcere. He was a Canon and Prebendary of York, and also of Soissons and Laon. In the summer of 1244, he was one of five cardinals who fled to Genoa with Pope Innocent IV. He was at Lyons, and was present in June and July for the Ecumenical Council of Lyons. Cardinal Orsini and the Curia did not return to Italy until May 1251—after the