the presidency in the 1840 election but was passed over at the Whig National Convention by Harrison. When Harrison died and his vice president ascended to office, Clay clashed with Harrison's successor, John Tyler, who broke with Clay and other congressional Whigs after taking office upon Harrison's death in 1841. Clay resigned from the Senate in 1842 and won the 1844 Whig presidential nomination, but he was narrowly defeated in the general election by Democrat James K. Polk, who made the annexation of the Republic of Texas his top issue. Clay strongly criticized the subsequent Mexican–American War and sought the Whig presidential nomination in 1848 but was passed over in favor of General Zachary Taylor who went on to win the election. After returning to the Senate in 1849, Clay played a key role in passing the Compromise of 1850, which postponed a crisis over the status of slavery in the territories. Clay is generally regarded as one of the most important and influential political figures of his era. Early life Henry Clay was born on April 12, 1777, at the Clay homestead in Hanover County, Virginia. He was the seventh of nine children born to the Reverend John Clay and Elizabeth (née Hudson) Clay. Almost all of Henry's older siblings died before adulthood. His father, a Baptist minister nicknamed "Sir John", died in 1781, leaving Henry and his brothers two slaves each; he also left his wife 18 slaves and of land. Clay was of entirely English descent; his ancestor, John Clay, settled in Virginia in 1613. The Clay family became a well-known political family including three other US Senators, numerous state politicians, and Clay's cousin Cassius Clay, a prominent anti-slavery activist active in the mid-19th century. The "British" raided Clay's home shortly after the death of his father, leaving the family in a precarious economic position. However, the widow Elizabeth Clay married Captain Henry Watkins, who was an affectionate stepfather and a successful planter. Elizabeth would have seven more children with Watkins, bearing a total of sixteen children. After his mother's remarriage, the young Clay remained in Hanover County, where he learned how to read and write. In 1791, Watkins moved the family to Kentucky, joining his brother in the pursuit of fertile new lands in the West. However, Clay did not follow, as Watkins secured his temporary employment in a Richmond emporium, with the promise that Clay