Kate's 1st daughter, Bud's wife, and baby Tom’s mother. Tom Welling as Charlie Baker, Tom & Kate's 1st son who becomes a mechanic in order to pay off some college tuition. Hilary Duff as Lorraine Baker, Tom & Kate's 2nd daughter who is planning to move to New York so that she can intern at Allure Magazine. Kevin G. Schmidt as Henry Baker, Tom & Kate's 2nd son. Alyson Stoner as Sarah Baker, Tom & Kate's 3rd daughter. Jacob Smith as Jake Baker, Tom & Kate's 3rd son. Forrest Landis as Mark Baker, Tom & Kate's 4th son. Liliana Mumy as Jessica Baker, Tom & Kate's 4th daughter and Kim's fraternal twin sister. Morgan York as Kim Baker, Tom & Kate's 5th daughter and Jessica's fraternal twin sister. Blake Woodruff as Mike Baker, Tom & Kate's 5th son. Brent Kinsman as Kyle Baker, Tom & Kate's 6th son and Nigel's identical twin brother. Shane Kinsman as Nigel Baker, Tom & Kate's 7th son and Kyle's identical twin brother. Murtaughs Eugene Levy as Jimmy Murtaugh, the patriarch of the Murtaugh family who is an old rival of Tom. Carmen Electra as Sarina Murtaugh, the matriarch of the Murtaugh family and Jimmy's trophy wife. Shawn Roberts as Calvin Murtaugh, Jimmy's 1st son. Jaime King as Anne Murtaugh, Jimmy's 1st daughter who becomes Charlie's love interest and conceals a butterfly back tattoo from her father. Robbie Amell as Daniel Murtaugh, Jimmy's 2nd son. Melanie Tonello as Becky Murtaugh, Jimmy's 2nd daughter. Taylor Lautner as Elliot "Eliot" Murtaugh, Jimmy's 3rd son who becomes Sarah's love interest. Courtney Fitzpatrick as Lisa Murtaugh, Jimmy's 3rd daughter and Robin's identical twin sister. Madison Fitzpatrick as Robin Murtaugh, Jimmy's 4th daughter and Lisa's identical twin sister. Alexander Conti as Kenneth "Kenny" Murtaugh, Jimmy's 4th son. Others Jonathan Bennett as Bud McNulty, Nora's husband and Tom & Kate's son-in-law (the father of Tom). Peter Keleghan as Mike Romanow, Jimmy’s neighbor and friend who is the owner of the old cabin at Lake Winnetka that the Baker family rents. The director of the first film, and producer of the sequel, Shawn Levy, has a cameo as a hospital intern. Ben Falcone appears as a theater patron that gets annoyed with Tom and Jimmy's argument. Soundtrack "I Wish" – Stevie Wonder "Graduation Day Song" – Joseph L. Altruda "Mexicali Mondays" – Christopher Lightbody and Robert Steinmiller "What If" – Gina Rene