Nutty Professor II: The Klumps is a 2000 American science fiction comedy film directed by Peter Segal. It is the sequel to the 1996 film The Nutty Professor. In contrast to the previous film, subplots which are centered on the parents of protagonist Sherman Klump occupy a substantial part of the film. Members of the Klump family, including Sherman's parents, also provide an increased level of comic relief. Plot Professor Sherman Klump has created a new de-aging formula. He is also in love with DNA researcher, Denise Gaines, developer of a method to isolate genetic material. Despite his good fortune, Sherman's major problem is his id alter ego, Buddy Love. He is still ingrained inside him and has begun to periodically take control of his body. Buddy's antics culminate in the corruption of Sherman's attempted proposal to Denise into a mortifying display of perversion. Determined to be rid of Buddy permanently, and despite his assistant, Jason, warning him of potential consequences, Sherman uses Denise's methodology to isolate and remove the DNA where Buddy has manifested. However, the Buddy genetic material grows into a sentient being when a hair from Jason's Basset Hound, Buster, accidentally lands in it. Sherman apologizes to Denise and they become engaged. Later, Dean Richmond informs them that Phleer Pharmaceuticals has offered Wellman College $150 million for the youth formula. Sherman and Denise then encounter the newly reformed Buddy at a movie theater. Buddy pickpockets Sherman and learns of the $150 million offer. He subsequently visits the pharmaceutical company, making a rival bid of $149 million with Leanne Guilford, President of Acquisitions, for the youth formula. Sherman learns that the extraction has altered his body chemistry and that he is losing his intelligence. Realizing he needs to keep the youth formula out of Buddy's hands, Sherman stashes it at his parents'. Sherman's sexually frustrated father Cletus accidentally drinks some of the youth formula. He goes out for a night on the town and attempts to seduce his wife and Sherman's mother, Anna, but she is horrified. Buddy witnesses Cletus changing and realizes that the youth formula is being stored in the Klump household. Meanwhile, Sherman's condition causes him to act like a fool in front of Denise's parents, concerning her. Buddy steals some of the youth formulae from the Klump household, filling the vial the rest of the way with fertilizer. This sabotage causes chaos at a