from a concrete grave. Jack's daughter Alice (Lucy Cohu) and grandson Steven (Bear McCausland) are taken into custody by the assassins. The 4-5-6 demand ten percent of the world's children. Although he handed over twelve children in 1965, Jack refuses to give up any this time around. The 4-5-6 release a fatal virus; Ianto dies in Jack's arms. To create the signal that will destroy the 4-5-6, Jack sacrifices Steven. Six months later, having lost his lover, his grandson and his daughter, he bids farewell to Gwen and is transported aboard an alien ship to leave Earth for parts unknown. In the closing scenes of 2010 Doctor Who special "The End of Time", the critically injured Doctor gives each companion a farewell before his impending regeneration. Finding Jack in an exotic alien bar, he leaves him a note containing the name of Titanic crew member Alonso Frame (Russell Tovey), sitting on Jack's left side; the two proceed to flirt. The fourth series, Miracle Day (2011), an American co-production, sees Jack return to Earth to investigate a phenomenon where humans can no longer die; Jack discovers that he has become mortal. Investigating their connection to the so-called "miracle", CIA agent Rex Matheson (Mekhi Phifer) renditions Jack and Gwen to America, but joins the team along with CIA colleague Esther Drummond (Alexa Havins) after conspirators within the CIA betray them. Jack's investigations into the miracle repeatedly turn up dead-ends, indicating a decades-old conspiracy to manipulate the global economy, as well as political institutions, for unknown purposes. Flashbacks in "Immortal Sins" depict Jack's relationship with Italian thief Angelo Colasanto (Daniele Favilli) in late 1920s New York City, ending in heartbreak after Jack is killed, bled and tortured repeatedly by the local community. In the present day, Angelo's granddaughter Olivia (Nana Visitor) explains that the descendants of three local businessmen who wished to purchase Jack's powers—"the Three Families"—are responsible for the miracle, using Jack's blood in conjunction with what they call "the Blessing". In "The Gathering", the team ultimately track down the Families and the Blessing, which is revealed to be an antipodal geological formation connected to the Earth's morphic field running from Shanghai and Buenos Aires; the team divide, attempting to reach both access points. To end the miracle, in "The Blood Line", Jack has Gwen kill him so that his mortal blood can reset the human morphic field; Gwen kills him with