demonstration the next day as Petey, the male hamster Sherman uses to demonstrate the formula, mutates into a giant monster who violates Richmond as he is trying to escape under a fur coat, as Petey confuses him for Molly, the female hamster that escaped during the event. The humiliated and enraged Richmond fires Sherman, who soon learns from Jason that his brain's deterioration has worsened, so he decides to break up with Denise. Cletus consoles a depressed Sherman, and inadvertently gives him the solution to regaining his intelligence: getting Buddy Love back into his DNA. Sherman quickly works on a newer, much more potent formula while his mental faculties allow him. Richmond confronts him about Buddy's actions, believing that they are working together. Sherman leaves with Richmond and a tennis ball covered in the youth formula and heads to a presentation at Phleer Pharmaceuticals that Buddy is giving about the youth formula. Meanwhile, a worried Denise discovers what has happened and that Sherman's brain damage is progressing. With Cletus' help, Denise goes after him. Sherman takes advantage of the canine DNA crossed with Buddy's and throws the tennis ball to distract him. Buddy catches the ball in his mouth, and the youth formula transforms him back into a glowing mass of sentient genetic material. Sherman chases the genetic material, intent on drinking it to correct his condition. However, it evaporates on the edge of a fountain before he can. Cletus and Denise arrive too late to save him, and Denise breaks into tears, which hit the genetic material and fall into the fountain. As they go to leave, Sherman looks into the fountain, remarking that it is "pretty". Seeing the water is glowing, Denise realizes the genetic material has reconstituted thanks to her tears and that if Sherman drinks the fountain water, he will be restored to normal. When he drinks it, he is able to restore his intelligence. Sherman and Denise later get married, while Cletus and Anna reconcile with each other. Cast Eddie Murphy as Professor Sherman Klump / Buddy Love / Papa Cletus Klump / Young Papa Cletus Klump / Ernie Klump Sr. / Mama Anna Klump / Grandma Ida Jenson / Lance Perkins Janet Jackson as Denise Gaines-Klump Larry Miller as Dean Richmond John Ales as Jason Richard Gant as Mr. Gaines Anna Maria Horsford as Mrs. Gaines Melinda McGraw as Leanne Guilford Jamal Mixon as