McIntosh starred in Bodies, a medical drama produced by BBC Three and based on the book Bodies by Jed Mercurio. She has also appeared in several other television dramas, including Psychos, Ghost Squad, Marple, Murder City, Bodies-2 and Low Winter Sun. She also recorded an episode of Law & Order: UK. In December 2009 McIntosh appeared in an episode of Sky 1's 10 Minute Tales playing the wife of Peter Capaldi's character. In May 2010, McIntosh appeared in two episodes of the 2010 series of Doctor Who beside the Doctor played by Matt Smith. She plays Alaya and Restac, two Silurian sisters who have been disturbed under the earth, one captured by humans and the other demanding vengeance. In October 2010, she starred alongside former Doctor Who star, David Tennant, in Single Father, a BBC drama. She portrayed the part of Anna, the sister of the dead wife of Tennant's character (Dave). McIntosh returned as a new Silurian character, Madame Vastra, in the Doctor Who Series 6 mid-series episode "A Good Man Goes to War", which aired in the UK on 4 June 2011. The character is a sword-wielding, human-eating late Victorian crime fighter, and an old friend of The Doctor. Neve McIntosh appeared in Ripper Street for one episode in the November 2013 episode 3 "Become Man" where she played the character Raine. She also appeared as Janina for 2 episodes of Dracula – a British-American horror drama TV series that premièred on NBC on 25 October 2013. The series aired in the United Kingdom from 31 October 2013, to 16 January 2014, on Sky Living. McIntosh appeared in the BBC One series Case Histories as Joanna Hunter which aired in June 2011. She also starred in Season 2 of the BBC Three drama, Lip Service, as a love interest of one of the main characters, Sadie. McIntosh returned to Doctor Who in the 2012 Christmas special, and in the episodes "The Crimson Horror" and "The Name of the Doctor". In each of these episodes, she reprises her role as Madame Vastra, who along with her wife, Jenny Flint, and Strax, a former Sontaran nurse, form an investigating team. While there is a suggestive chemistry between Vastra and her chambermaid Jenny, in "A Good Man Goes to War", the later episodes explicitly mention that Vastra and Jenny are married. In 2017, McIntosh played Kay Gillies in the BBC One