Los Santos may refer to: Places Los Santos, Santander, Colombia Los Santos Zone, San José Province, Costa Rica Los Santos Province, Panama Los Santos District La Villa de los Santos Los Santos, Castile and León, Spain Los Santos mine Los Santos de la Humosa, Spain Los Santos de Maimona, Spain Other uses Los Santos, a fictional setting in the video game series Grand Theft Auto See also Santos (disambiguation) Santa (disambiguation) Santo (disambiguation)