before the properties of the toxic gas could be determined, partly because a suitable synthesis was not available. In 1876 Francis Jones tested several synthesis methods, but it was not before 1901 when Alfred Stock determined most of the properties of stibine. Safety SbH3 is an unstable flammable gas. It is highly toxic, with an LC50 of 100 ppm in mice. Toxicology The toxicity of stibine is distinct from that of other antimony compounds, but similar to that of arsine. Stibine binds to the haemoglobin of red blood cells, causing them to be destroyed by the body. Most cases of stibine poisoning have been accompanied by arsine poisoning, although animal studies indicate that their toxicities are equivalent. The first signs of exposure, which can take several hours to become apparent, are headaches, vertigo, and nausea, followed by the symptoms of hemolytic anemia (high levels of unconjugated bilirubin), hemoglobinuria, and nephropathy. See also Antimony (Sb) Arsine (AsH3) Devarda's alloy, also used to produce arsine and stibine in the lab List of highly toxic gases Marsh test, first used to analyse AsH3 and SbH3 James Marsh, invented the Marsh test in 1836 Nascent hydrogen References External links International Chemical Safety Card 0776 NIOSH Pocket Guide to Chemical Hazards Antimony(III) compounds Metal hydrides