polyphenols in Extra Virgin Olive Oil. Each of these bioactive compounds, along with several others, interact with the body's cellular and molecular function, gene expression and epigenome to prevent angiogenesis and the development of neurodegenerative disease. Applications The applications of nutritional genomics are multiple. With personalized assessment some disorders (diabetes, metabolic syndrome) can be identified. Nutrigenomics can help with personalized health and nutrition intake by assessing individuals and make specific nutritional requirements. The focus is in the prevention and the correction of specific genetic disorders. Examples of genetic related disorders that improve with nutritional correction are obesity, coronary heart disease (CHD), hypertension and diabetes mellitus type 1. Genetic disorders that can often be prevented by proper nutritional intake of parents include spina bifida, alcoholism and phenylketouria. Coronary heart disease Genes tied to nutrition manifest themselves through the body's sensitivity to food. In studies about CHD, there is a relationship between the disease and the presence of two alleles found at E and B apolipoprotein loci. These loci differences result in individualized reactions to the consumption of lipids. Some people experience increased weight gain and greater risk of CHD whereas others with different loci do not. Research has shown a direct correlation between the decrease risk of CHD and the decrease consumption of lipids across all populations. Obesity Obesity is one of the most widely studied topics in nutritional genomics. Due to genetic variations among individuals, each person could respond to diet differently. By exploring the interaction between dietary pattern and genetic factors, the field aims to suggest dietary changes that could prevent or reduce obesity. There appear to be some SNPs that make it more likely that a person will gain weight from a high fat diet; for people with AA genotype in the FTO gene showed a higher BMI compared those with TT genotype when having high fat or low carbohydrate dietary intake. The APO B SNP rs512535 is another diet-related variation; the A/G heterozygous genotype was found to have association with obesity (in terms of BMI and waist circumference) and for individuals with habitual high fat diet (>35% of energy intake), while individuals with GG homozygous genotype are likely to have a higher BMI compared to AA allele carriers. However, this difference is not found in low fat consuming group (<35% of energy intake). Phenylketonuria Phenylketonuria, otherwise known as PKU, is an uncommon autosomal recessive metabolic disorder that