DNA damage, and can pair with adenine and guanine through hydrogen bonding causing G-T transversions and G-C transversions, respectively. Transversion and p53 mutations in smoking-associated cancers The mutation of the P53 gene is the most common gene mutation found in cancer cells. A study has shown that p53 mutations are common in tobacco-related cancers, with a variation in the amount of G-T transversions in lung cancer from smokers and non-smokers. In smokers’ lung cancer, the prevalence of G-T transversions is 30% compared to that of 12% in non-smokers. At many p53 mutational hotspots, a large number of the mutations are G-T events in lung cancers but almost exclusively G-A transitions in non-tobacco-related cancers. See also Transition Aristolochic acid, a natural plant chemical causing A → T and T → A transversions in humans P53 Guanine DNA oxidation Oxidative stress References External links Mutation