Neonatal inclusion conjunctivitis caused by C. trachomatis should be treated with oral erythromycin. Topical therapy is not effective and also does not treat the infection of the nasopharynx. Herpes simplex conjunctivitis should be treated with intravenous acyclovir for a minimum of 14 days to prevent systemic infection. Epidemiology The incidence of neonatal conjunctivitis varies widely depending on the geographical location. The incidence in England was 257 (95% confidence interval: 245 to 269) per 100,000 in 2011. See also List of systemic diseases with ocular manifestations References External links Eye diseases Disorders of conjunctiva Herpes simplex virus–associated diseases Neonatology Chlamydia infections Gonorrhea