corticosteroids, supplemented with antibiotics and antacids (to compensate for the decreased thickness of the stomach's mucosal lining as a result of the corticosteroids and to decrease the possibility of forming stomach ulcers). More severe cases that are not recognized and treated early often require IV fluids, electrolytes, nutritional support, and significant nursing care to achieve successful results. AKC parent clubs have supported research into the genetic causes of HOD, and have reported fairly good success using this protocol, saving many puppies from unnecessary suffering, deformity, and death. NOTE: Supplementation of Vitamin C is contraindicated due to an increase in calcium levels in the blood, possibly worsening the disease. Breeds at increased risk for HOD Alaskan Malamute American Akita Boxer Chesapeake Bay Retriever Dalmatian German Shepherd Dog Golden Retriever Great Dane Irish Setter Irish Wolfhound Japanese Akita Labrador Retriever Newfoundland Slovakian Rough Haired Pointer Weimaraner References Dog diseases