Adrenocorticotropic hormone deficiency (ACTH deficiency) is a result of a decreased or absent production of adrenocorticotropic hormone (ACTH) by the pituitary gland. It can be associated with TBX19. Presentation Symptoms include weakness, hypoglycemia, weight loss and decreased axillary and pubic hair. It can be either isolated or part of a generalised pituitary dysfunction. It can be life-threatening if not recognised. Diagnosis It is usually diagnosed on basis of an ACTH or insulin tolerance test in combination with the clinical symptoms. Treatment Treatment is with hydrocortisone supplementation. See also Hypopituitarism References External links Adrenal gland disorders Transcription factor deficiencies Pituitary disorders