State Road 46 (SR 46) is an east–west route in central Florida, running from U.S. Route 441 (US 441) in Mount Dora to US 1 in Mims. Along the way, it crosses the Wekiva River and, further east, the St. Johns River near the Econlockhatchee River. County Road 46 continues west from the western terminus to County Road Old 441 in Mount Dora. Route description State Road 46 begins as Sanford Road at an at-grade intersection with US 441, where it changes from a County Road to a State Road. Here, there are direct ramp movements connecting southbound US 441 with eastbound State Route 46 and westbound State Road 46 to northbound US 441. After the intersection with Round Lake Road, SR 46 turns northeast and runs parallel to an abandoned railroad line, which it then curves away from, but then encounters at a former grade crossing in Sorrento just west of the intersection with County Road 437, which shares a brief concurrency with SR 46 for several blocks. East of Sorrento, the road becomes Sorrento Avenue, a name it maintains as it passes by County Road 435 in Mount Plymouth, and then Seminole State Forest. Before entering the forest however, SR 46 passes by Mount Plymouth Lake to the south, intersecting County Road 46A at an at-grade intersection and the current northern terminus of State Route 429 at a modified diamond interchange, merging onto the latter's future alignment. Here, State Road 46 also encounters the same right-of-way for the abandoned railroad to the north, which runs parallel to the road as even after it leaves the forest on a bridge over the Wekiva River at the Lake-Seminole County line becoming North Henderson Lane, and running along the south end of Lower Wekiva River Preserve State Park. After the intersections with Orange Avenue and Wayside Drive, SR 46 becomes a four lane divided highway before reaching the interchange with Interstate 4, and later joins a concurrency with U.S. Route 17/92, the latter of these routes is in a wrong-way concurrency. Along this segment, US 17/92/SR 46 passes by the Sanford SunRail station before it climbs a bridge over the CSX Sanford Subdivision then intersects Persimmon Avenue, a road leading to the Sanford Auto Train Station, and former passenger station. Eventually the triple-concurrency enters the City of Sanford where it is renamed West First Street. Closer to downtown Sanford the divider