A74 or A-74 may refer to: A74 road, a major road in the United Kingdom A74(M) and M74 motorways, another road in the United Kingdom that largely replaced the original A74 Benoni Defense, in the Encyclopaedia of Chess Openings HLA-A74, an HLA-A serotype Iceberg A-74, an iceberg calved from the Antarctic Brunt Ice Shelf in February 2021