Century or later. Three factors would combine to persuade 16th Century Bolivian liquor merchants to label their product: for those who could dominate it, the massively large market and wealth generator of nearby Potosi; the arrival of competing aguardiente products from Lower Peru; and a reliable trade-name—singani—by which their grape liquor could be bought and sold. The three likely areas where the use of the word singani got its start stretch in an arc from the Potosi to the Spanish royal road connecting Lima and Buenos Aires (partially based on the earlier Inca road system). Sivingani Canton in Mizque Province was an early religious mission center and wine producer in the 1540s. A native settlement called Sivingani lay aside the Uruchini River in the San Lucas municipality of Nor Cinti Province in an area known as the Cintis, and which is believed to have been producing wine and grape-based liquor as early as the 1550s. Another area includes placename settlements in the T'uruchipa Valley, the Vicchoca valley, and Santiago de Cotagaita. Augustinian missions were active in these areas about 1550 and they are among the closest locations to the mining center of Potosi which was the monumental consumer of singani in those days. After the founding of Potosi in 1545, Spanish settlers traveled from there to the Cintis to give birth, it being too cold and socially turbulent in Potosi. This would create an early connection between this wine region and the imperial city. Subsequently, residents of Potosi who acquired wealth founded villas in the valley of the Cintis. By 1585 this area became the major center of wine and singani production initiating many of the first non-monastic commercial ventures. During the 16th Century, Turuchipa was listed as delivering "vinos endebles" (weak wine) to Potosi, while Cinti delivered wine and distilled liquor. At that time each household in Potosi was observed to possess eight to ten "cántaros" or amphora-like jugs of alcoholic drink. This plus population estimates of 100,000 to 200,000 would provide some sense of the overall demand for wine, chicha, and liquor at that time and place. In the 1600s Bolivia's Tarija region became a supplier of fruit to the singani industry. By the 20th Century Tarija had become the dominant supplier, and wine and singani manufacturers began to consolidate their business there. For example, prominent distiller Kuhlmann moved their operations from the Cinti region to Tarija in