pathology of schizophrenia. Schizophrenia-like PPI disruption techniques in rodents have been classified in one review into four models: PPI impairment driven by dopamine-receptor agonists, most validated for antipsychotic studies; PPI impairment by 5-HT2 receptor agonists; PPI impairment by NMDAR antagonists; PPI impairment by developmental intervention (isolation rearing, maternal deprivation). Diverse chemical compounds are tested on animals with such deficits. Compounds that are able to restore PPI could be further investigated for their potential antipsychotic role. A review of the genetic underpinnings of prepulse inhibition can be found in a meta-analysis conducted by Quednow et al. (2017). Additionally an updated summary of both preclinical and clinical findings with PPI can be found in a recent comprehensive review. See also Latent inhibition References External links from Losing Your (Prepulse) Inhibitions—All About α3 GABAA? - Schizophrenia Research Forum Prepulse Inhibition Deficits Predict Functional Difficulties in Schizophrenia – Schizophrenia Research Forum An Analysis of Nicotine Exacerbation of Reductions in PPI in a Rodent Model of Schizophrenia – a master's thesis with a thorough review of schizophrenia PPI disruption models in rodents Neuroscience of schizophrenia Sensory systems Neurology