risk for both Alzheimer's and sporadic Creutzfeldt–Jakob disease. A point mutation on codon 102 of PRNP at least in part contributed to three separate patients' atypical frontotemporal dementia within the same family, suggesting a new phenotype for Gerstmann–Sträussler–Scheinker syndrome. The same study proposed sequencing PRNP in cases of ambiguously diagnosed dementia, as the various forms of dementia can prove challenging to differentially diagnose. Interactions A strong interaction exists between PrP and the cochaperone Hop (Hsp70/Hsp90 organizing protein; also called STI1 (Stress-induced protein 1)). References External links PRNP (PrP) gene at GeneCard Susan Lindquist's Seminar: "The Surprising World of Prion Biology" Clusters of differentiation Amyloidosis