III abandoned claims to a Parthian sphere of influence in Armenia. War erupted in 58 AD, after the Parthian King Vologases I forcibly installed his brother Tiridates on the Armenian throne. Roman forces overthrew Tiridates and replaced him with a Cappadocian prince, triggering an inconclusive war. This came to an end in 63 AD after the Romans agreed to allow Tiridates and his descendants to rule Armenia on condition that they receive the kingship from the Roman emperor. A fresh series of conflicts began in the 2nd century AD, during which the Romans consistently held the upper hand over Parthia. The Emperor Trajan invaded Armenia and Mesopotamia during 114 and 115 and annexed them as Roman provinces. He captured the Parthian capital, Ctesiphon, before sailing downriver to the Persian Gulf. However, uprisings erupted in 115 AD in the occupied Parthian territories, while a major Jewish revolt broke out in Roman territory, severely stretching Roman military resources. Parthian forces attacked key Roman positions, and the Roman garrisons at Seleucia, Nisibis and Edessa were expelled by the local inhabitants. Trajan subdued the rebels in Mesopotamia, but having installed the Parthian prince Parthamaspates on the throne as a client ruler, he withdrew his armies and returned to Syria. Trajan died in 117, before he was able to reorganize and consolidate Roman control over the Parthian provinces. Trajan's Parthian War initiated a "shift of emphasis in the 'grand strategy of the Roman empire' ", but his successor, Hadrian, decided that it was in Rome's interest to re-establish the Euphrates as the limit of its direct control. Hadrian returned to the status quo ante, and surrendered the territories of Armenia, Mesopotamia, and Adiabene to their previous rulers and client-kings. War over Armenia broke out again in 161, when Vologases IV defeated the Romans there, captured Edessa and ravaged Syria. In 163 a Roman counter-attack under Statius Priscus defeated the Parthians in Armenia and installed a favored candidate on the Armenian throne. The following year Avidius Cassius invaded Mesopotamia, winning battles at Dura-Europos and Seleucia and sacking Ctesiphon in 165. An epidemic which was sweeping Parthia at the time, possibly of smallpox, spread to the Roman army and forced its withdrawal; this was the origin of the Antonine Plague that raged for a generation throughout the Roman Empire. In 195–197, a Roman offensive under the Emperor Septimius Severus led to Rome's acquisition of northern Mesopotamia as