tert-Butyllithium is a chemical compound with the formula (CH3)3CLi. As an organolithium compound, it has applications in organic synthesis since it is a strong base, capable of deprotonating many carbon molecules, including benzene. tert-Butyllithium is available commercially as hydrocarbon solutions; it is not usually prepared in the laboratory. Preparation tert-Butyllithium is produced commercially by treating tert-butyl chloride with lithium metal. Its synthesis was first reported by R. B. Woodward in 1941. Structure and bonding Like other organolithium compounds, tert-butyllithium is a cluster compound. Whereas n-butyllithium exists both as a hexamer and a tetramer, tert-butyllithium exists exclusively as a tetramer with a cubane structure. Bonding in organolithium clusters involves sigma delocalization and significant Li−Li bonding. Despite its complicated structure, tert-butyllithium is usually depicted in equations as a monomer. The lithium–carbon bond in tert-butyllithium is highly polarized, having about 40 percent ionic character. The molecule reacts like a carbanion, as is represented by these two resonance structures. Reactions tert-Butyllithium is renowned for deprotonation of carbon acids (C-H bonds). One example is the double deprotonation of allyl alcohol. Other examples are the deprotonation of vinyl ethers. In combination with n-butyllithiium, tert-butylllithium monolithiates ferrocene. tert-Butyllithium deprotonates dichloromethane: Similar to n-butyllithium, tert-butyllithium can be used for lithium-halogen exchange reactions. Solvent compatibility To minimize degradation by solvents, reactions involving tert-butyllithium are often conducted at very low temperatures in special solvents, such as the Trapp solvent mixture. Moreso than other alkyllithium compounds, tert-butyllithium reacts with ethers. In diethyl ether, the half-life of tert-butyllithium is about 60 minutes at 0 °C. It is even more reactive toward tetrahydrofuran (THF), the half-life in THF solutions is about 40 minutes at −20 °C. In dimethoxyethane, the half-life is about 11 minutes at −70 °C In this example, the reaction of tert-butyllithium with (THF) is shown: Safety tert-butyllithium is a pyrophoric substance, meaning that it spontaneously ignites on exposure to air. Air-free techniques are important so as to prevent this compound from reacting violently with oxygen and moisture: t-BuLi + O2 → t-BuOOLi t-BuLi + H2O → t-BuH + LiOH The solvents used in common commercial preparations are themselves flammable. While it is possible to work with this compound using cannula transfer, traces of tert-butyllithium at the tip of the needle or cannula may ignite and clog the cannula with lithium salts. While some researchers take this "pilot light" effect as a sign that the product is "fresh" and has not