B22 or B-22 may refer to: Science and technology B22, a bayonet mount size for a light bulb B22, an iceberg that calved from the Thwaites Ice Tongue in 2002 HLA-B22, an HLA-B serotype AIDS dementia complex (ICD-10 code) Transportation Bundesstraße 22, a German road Chery B22, a 2008 Chinese Chery Automobile model Douglas XB-22, a proposed modification of the B-18 Bolo bomber MWfly B22, an Italian aircraft engine design Micro Aviation B22 Bantam, a New Zealand ultralight aircraft design Other uses Sicilian Defence (ECO code), in chess