introduced the pulsilogium in 1602 and thermoscope in 1611. The pulsilogium was probably the first machine of precision in medical history. Extensive experimentation with his new tool allowed Santorio to standardise the Galenic rationale of the pulse and to describe quantitatively various regular and irregular frequences. A century later, another physician, François Boissier de Sauvages de Lacroix used the pulsilogium to test cardiac function. Study of metabolism Sanctorius studied the so-called perspiratio insensibilis or insensible perspiration of the body, already known to Galen and other ancient physicians, and originated the study of metabolism. For a period of thirty years, Santorio used a chair-device to weigh himself and everything he ate and drank, as well as his urine and feces. He compared the weight of what he had eaten to that of his waste products, the latter being considerably smaller because for every eight pounds of food he ate, he excreted only 3 pounds of waste. Santorio also applied his weighing device to study his patients, but records of these experiments have been lost. His notable conclusion on finding this was that:Insensible Perspiration is either made by the Pores of the Body, which is all over perspirable, and cover’d with a Skin like a Net; or it is performed by Respiration through the Mouth, which usually, in the Space of one Day, amounts to about the Quantity of half a Pound, as may plainly be made appear by breathing upon a Glass.This important experiment is the origin of the significance of weight measurement in medicine. While his experiments were replicated and augmented by his followers and were finally surpassed by Antoine Lavoisier in 1790, he is still celebrated as the father of experimental physiology. The "weighing chair", which he constructed and employed during this experiment is also famous. Bibliography Methodus vitandorum errorum omnium qui in arte medica contigunt (1602) Commentaria in artem medicinalem Galeni (1612) De Statica medicina (1614 ) Commenteria in primam Fen primi Canonis Avicennae (1625) Commenteria in primam sectionem Aphorismorum Hippocratis (1629) De remediorum inventione (1638 ) De lithotomia seu calculi vesicae consultatio co-authored with L. Batarourum (1629) ( Posthumous) De instrumentis medicis (unpublished) Grants named after Santorio In January 2018 the Italian Institution Institutio Santoriana – Fondazione Comel created the Centre for the Study of Medicine and the Body in the Renaissance (CSMBR) as an International Institution of advanced research in honour of Santorio to study medical