patients will develop liver metastases. As such, the majority of surveillance techniques are focused on the liver. These include abdominal magnetic resonance imaging (MRI), abdominal ultrasound and liver function tests. The scientific community is currently working to develop guidelines, but until then, each patient must take into consideration their individual clinical situation and discuss appropriate surveillance with their doctors. Some ophthalmologists have also found promise with the use of intravitreal avastin injections in patients with radiation-induced retinopathy, a side effect of plaque brachytherapy treatment, as well as imaging surveillance with SD-OCT. Epidemiology Uveal melanomas are the most common primary intraocular tumor in adults. Uveal melanoma is classified as a rare cancer with 5.1 cases per million people per year. The incidence has remained stable for several years. There are about 2500 patients with UM diagnosed annually in the US. Apparent clustering In 2018, it was reported that two clusters of cases have been identified in Huntersville, North Carolina, and Auburn, Alabama. Cases involved alumni of Auburn University who were acquainted with each other. Health officials investigated and found that the "cluster" is an artifact of social networking. History Uveal melanoma was first described in the literature in 1809-1812 by two Scottish surgeons, Allan Burns and James Wardrop. See also Melanoma Eye cancer DecisionDx-UM References External links National Organization for Rare Diseases - Ocular Melanoma Cancer Research UK National Cancer Institute - Intraocular (Eye) Melanoma—Patient Version Ocular Melanoma Foundation A Cure In Sight Ocular neoplasia Melanoma Rare diseases Eye color Rare cancers