Creek as it begins paralleling the Yalobusha River, passing through farmland to cross into the northwestern most corner of Carroll County, where it passes through Avalon, before entering Grenada County. MS 7 passes through Malmaison State Wildlife Management Area and Leflore to enter Holcomb, where it bypasses town along its north side, has an extremely short concurrency with MS 35, and becomes concurrent with MS 8. MS 7/MS 8 head east to climb into the North Central Hills region and enter Grenada. The highway widens to a four-lane undivided boulevard as it passes through an industrial area for a few miles to an interchange with I-55 (Exit 206) just west of downtown, where MS 7 splits from MS 8 and heads north along I-55. I-55/MS 7 head north as a four-lane freeway to cross the Yalobusha River and have an interchange with Papermill Road (Exit 208). They now pass through the Geeslin Corner neighborhood to leave Grenada and come to Exit 211 (unsigned MS 729), where MS 7 splits off and heads northeast as a two-lane. The highway has an intersection with MS 333 Scenic before crossing into Yalobusha County. MS 7 passes along the northern banks of Grenada Lake for several miles to enter the town of Coffeeville, which it bypasses along its western side while also having an intersection with MS 330. It heads through mostly wooded areas for several miles, where it passes through the community of Velma, to enter the town of Water Valley. It widens to a four-lane divided highway as it bypasses downtown along its western side and has intersections with MS 32 and MS 315. The highway now narrows back to two-lanes as it enters wooded areas and crosses into Lafayette County. MS 7 heads northeast to pass through Springdale before turning north at a Y-Intersection with MS 9W and crossing over the Yocona River. It then has an intersection with MS 328 before entering the Oxford city limits and passes through neighborhoods for a few miles to an interchange with US 278/MS 6, which provides access to the main campus of the University of Mississippi (Ole Miss). The highway now widens to a four-lane divided freeway to bypass downtown along its eastern side and have interchanges with MS 314 (University Avenue), Sisk Avenue, and MS 30 (Molly Barr Road), where the freeway ends and MS 7 narrows back to two-lanes to leave