In 1959, Blake guest-starred in the first episode, "The Good Samaritan," of the syndicated Western series Pony Express. That same year, her guest appearance in the short-lived series The D.A.'s Man garnered her an Emmy nomination. She appeared in a Gunsmoke episode called "Wind" in March 1959. Blake played a gambler's lady who tried to shoot Matt Dillon in the back. She also guest-starred on an episode of the detective series 77 Sunset Strip. Blake appeared in the 1959 film -30-, with Jack Webb, as a childless couple wanting to adopt a baby. The "-30-" comes from the symbol at the end of a newspaper story, as Webb played a newspaperman in the film. Appeared in the first season of the serie Bonanza, chapter 12. In 1960, she played Callie Carter in the Rawhide episode "Incident Of The Murder Steer" (Season 2, Episode 28). Blake guest-starred on Mike Connors' CBS detective series, Tightrope; the CBS sitcom, Pete and Gladys; and on the NBC Western series, Riverboat, starring Darren McGavin; and Overland Trail, with William Bendix and Doug McClure. She performed the lead female dramatic role on the Route 66 TV series in a January 1960 episode (first season). She also guest-starred on police drama TV series M Squad, starring Lee Marvin (Season 3, Episode 25). In 1960, with Robert Lansing, she co-starred in an episode of the TV series Thriller. Blake is best remembered for her portrayal of Dorothy Baxter, an interior designer and the wife of George Baxter (Don DeFore), a lawyer, on the NBC sitcom Hazel (1961), starring Shirley Booth in the title role as a bossy maid. Bobby Buntrock played her son, Harold Baxter. Oddly, Blake played Mrs. Baxter on Hazel, which had also been the name of her first husband and the surname of her three children in real life. Following the show's cancellation by NBC in 1965, DeFore and Blake were dropped from the series when CBS picked up the show for one more season. They were replaced by Ray Fulmer and Lynn Borden, respectively, in the roles of Steve and Barbara Baxter, the younger brother and sister-in-law of George Baxter. After Hazel, Blake guest-starred in an episode of the ABC Western series The Legend of Jesse James. In 1966, she appeared in the episode "Nice Day for a Hanging" of Chuck Connors' NBC Western series, Branded. In 1968, she appeared in a final season