Domenico di Bartolo (birth name Domenico Ghezzi), born in Asciano, Siena, was a Sienese painter who became active during the early Renaissance period. He was inaccurately named by the famous painter, writer and historian Giorgio Vasari as the nephew of well-reputed Italian artist Taddeo di Bartolo, who is featured in Vasari's Lives of the Most Excellent Painters, Sculptors, and Architects. By the early 1400s, Domenico di Bartolo was one of Siena's artists most influenced by the new Florentine style of painting. During the time that he was active and working, Domenico was the only Sienese painter to have received commissions by clients in Florence. Domenico was also employed by Lorenzo Vecchietta, otherwise referred to as Lorenzo di Pietro, to work alongside him for the fresco The Care of the Sick, which is today considered a masterpiece of the Pilgrim's Hall in the hospital Santa Maria della Scala (Siena). Domenico first surfaced into the world of early Renaissance art in 1420. He, along with several other unknown Sienese artists, was documented to be part of a restoration project to paint the Siena Cathedral. He is first recorded as a master in 1428, in a list of the painters' guild (ruolo dei pittori). His first surviving signed and dated work comes from 1433: 'The Madonna of Humility and Four Music-Making Angels'. In 1433 he also painted the "Virgin and Child Surrounded by Saints". A year later, in 1434, Domenico provided a design for a pavement plaque in the Cathedral of Siena based on a drawing of the Emperor Sigismund, who sojourned at Siena from 1432 to 1433. From 1435 to 1440 Domenico was engaged in a fresco commission for the cathedral's sacristy. This work, however, was interrupted in 1438 which gave Domenico time to go to Perugia to paint an altarpiece for the monastery church of Santa Giuliana, which is now displayed in the Galleria Nazionale dell'Umbria. In 1437 he also took on a contract to execute an altarpiece for the monks of Saint'Agostino at Asciano. By 1439, Domenico had been paid to work in the hospital of Santa Maria della Scala (Siena). The frescoes executed in the Pellegrinaio of the hospital between 1439 and 1440 represent scenes of the institution's history and good works; they are the artist's last finished works and are considered to be his masterpieces. For the most part, Domenico's works were based in Perugia, and his only