The standard of care is the use of chemotherapy, surgical resection and radiation, although most aggressive neuroblastomas have demonstrated to be resistant to these therapies. Pancreatoblastoma Pancreatoblastoma is a rare form of neoplasia that develops mostly in pediatric patients. This type of malignant neoplasm mimics pancreatic development at 7 weeks of gestation and tends to affect, most commonly, young male children. The usual signs and symptoms for this disease are an abnormal abdominal mass, along with abdominal pain or obstructive jaundice, but these symptoms are not necessarily specific for pancreatoblastoma and make the diagnosis a more complicated process (no standardised guidelines). The aggressiveness of the tumors, biologically speaking, makes them often unresectable at the age of diagnosis, therefore requiring other forms of therapy to help shrink the tumor instead of completely resecting it. Surgical intervention is possible in more localized cases. Pleuropulmonary blastoma About 0.5% to 1% of all primary malignant lung tumors are childhood tumors of the lung, making it a rare form of neoplasm. Pleuropulmonary blastoma is one of the three sub-types of these tumors, which include pulmonary blastoma, fetal adenocarcinoma and pleuropulmonary blastoma. Pleuropulmonary blastomas are characterized by the proliferation of malignant immature mesenchymal cells, constituted by two main histological components (mesenchymal and epithelial) that resemble the lung at week 10 to 16 of gestation. The symptoms for this disease are non-specific, and radiologic features are not enough to give a definitive diagnosis and instead require histological analysis. Retinoblastoma Retinoblastoma is a rare form of eye neoplasm (found in the retina) that is mostly found in children, being the most common intraocular malignancy of infancy and childhood. The incidence is of one case per every 15,000 to 20,000 live births, and some of the most common symptoms of this disease are leukocoria and strabismus, iris rubeosis, hypopyon, hyphema, buphthalmia, orbital cellulites and exophthalmia. About sixty percent of cases are unilateral and rarely hereditary, although the remaining 40% where cases are either bilateral or multifocal are always related to hereditary mutations. Hereditary retinoblastoma is related to mutations in the RB1 gene, which not only increase the probability of developing retinoblastoma to about 90%, but also increase the probabilities of developing other forms of cancer. Chemotherapy, cryotherapy and brachytherapy are common forms of treatment along with laser, and the prognosis is now excellent for most forms of retinoblastoma. Glioblastoma multiforme Glioblastoma multiforme is a form of malignant, grade IV