tumor of the central nervous system. Most of diagnosed glioblastoma multiforme cases (around 90% are in fact primary gliomas) arise from normal glial cells by following a multistep oncogenesis process. The remainder are originated from lower grade tumors, and the expansion rate of these is distinctly slower than for primary gliomas. Glioblastoma has been linked to certain genetic alterations and deregulations, but it mostly occurs spontaneously and its progression is associated with deregulation of the G1/S checkpoints, as well as other genetic abnormalities commonly associated with tumor cells. Metastases of this cancer type is not usually reported, and the treatment for this disease often includes full tumor resection along with radiotherapy and chemotherapy. Immunotherapy, as well as integrin signaling pathways inhibitors are also useful for its treatment, and the prognosis depends on the localization of the tumor, the degree of malignancy, genetic profile, proliferation rate and patient's age. References Types of neoplasia Pediatric cancers