| Federalist | 18061810 18141816 1820 | | Incumbent resigned May 8, 1822.New member elected October 1, 1822.Federalist hold.Successor seated December 2, 1822.Successor later lost re-election in , see below. | nowrap | |- ! | Samuel Moore | | Democratic-Republican | 1818 | | Incumbent resigned May 20, 1822.New member elected October 1, 1822.Democratic-Republican hold.Successor seated December 2, 1822.Successor later re-elected in , see below. | nowrap | |- ! | Henry Baldwin | | Democratic-Republican | 1816 | | Incumbent resigned May 8, 1822 because of his declining health and failing finances.New member elected October 1, 1822.Democratic-Republican hold.Successor seated December 2, 1822.Successor later re-elected in , see below. | nowrap | |- ! | Thomas Van Swearingen | | Federalist | 1819 | | Incumbent died August 19, 1822.New member elected October 28, 1822.Federalist hold.Successor seated December 2, 1822.Successor later re-elected in , see below. | nowrap | |- ! | Ezekiel Whitman | | Federalist | 1808 (in Mass.)1810 1816 (in Mass.)1820 (Maine) | | Incumbent resigned June 1, 1822.New member elected between June and December 1822.Democratic-Republican gain.Successor seated December 2, 1822.Successor was not a candidate to the next term, see below. | nowrap | |- ! | William Hendricks | | Democratic-Republican | 1816 | | Incumbent resigned July 25, 1822 to run for Governor of Indiana.New member elected between July and December 1822.Democratic-Republican hold.Successor seated December 2, 1822.Successor also elected to the next term in , see below. | nowrap | |- ! | James Overstreet | | Democratic-Republican | 1818 | | Incumbent died May 24, 1822.Successor also elected to the next term.New member elected in October 1822.Democratic-Republican hold.Successor seated December 4, 1822.Successor later re-elected, see below. | nowrap | |- ! | Ludwig Worman | | Federalist | 1820 | | Incumbent died October 17, 1822.New member elected December 10, 1822.Democratic-Republican gain.Successor seated December 23, 1822.Successor had already been elected to the next term, see below. | nowrap | |- ! | James Blair | | Democratic-Republican | 1821 | | Incumbent resigned May 8, 1822.New member elected December 11, 1822.Democratic-Republican hold.Successor seated December 11, 1822.Successor later re-elected in , see below. | nowrap | |- ! | William Lowndes | | Democratic-Republican | 1812 | | Incumbent died October 27, 1822.New member elected December 13, 1822.Democratic-Republican hold.Successor seated January 6, 1823.Successor later re-elected, see below. | nowrap | |- ! | Samuel