was Edward III of England), so the throne passed to Philip VI, son of Charles of Valois. This, in addition to a long-standing dispute over the rights to Gascony in the south of France, and the relationship between England and the Flemish cloth towns, led to the Hundred Years' War of 1337–1453. The following century was to see devastating warfare, peasant revolts (the English peasants' revolt of 1381 and the Jacquerie of 1358 in France) and the growth of nationalism in both countries. The losses of the century of war were enormous, particularly owing to the plague (the Black Death, usually considered an outbreak of bubonic plague), which arrived from Italy in 1348, spreading rapidly up the Rhone valley and thence across most of the country: it is estimated that a population of some 18–20 million in modern-day France at the time of the 1328 hearth tax returns had been reduced 150 years later by 50 percent or more. Renaissance and Reformation The Renaissance era was noted for the emergence of powerful centralized institutions, as well as a flourishing culture (much of it imported from Italy). The kings built a strong fiscal system, which heightened the power of the king to raise armies that overawed the local nobility. In Paris especially there emerged strong traditions in literature, art and music. The prevailing style was classical. The Ordinance of Villers-Cotterêts was signed into law by Francis I in 1539. Largely the work of Chancellor Guillaume Poyet, it dealt with a number of government, judicial and ecclesiastical matters. Articles 110 and 111, the most famous, called for the use of the French language in all legal acts, notarised contracts and official legislation. Italian Wars After the Hundred Years' War, Charles VIII of France signed three additional treaties with Henry VII of England, Maximilian I of Habsburg, and Ferdinand II of Aragon respectively at Étaples (1492), Senlis (1493) and in Barcelona (1493). These three treaties cleared the way for France to undertake the long Italian Wars (1494–1559), which marked the beginning of early modern France. French efforts to gain dominance resulted only in the increased power of the Habsburg house. Wars of Religion Barely were the Italian Wars over, when France was plunged into a domestic crisis with far-reaching consequences. Despite the conclusion of a Concordat between France and the Papacy (1516), granting the crown unrivalled power in senior ecclesiastical appointments, France was