Turley completely eliminated his use of pharmaceuticals – including psychiatric and pain-killing drugs – beginning in early 2015 when he went cold turkey and switched to cannabis only. He has been active in speaking about his personal experience using cannabis, and in 2015 founded the Gridiron Cannabis Coalition to help advance policy change regarding the use of cannabis in professional sports. The organization is also involved with medical cannabis research, commencing a study in 2016 to examine the effectiveness of cannabis in treating chronic pain and depression. In November 2016, Turley was among the signatories of an open letter addressed to the NFL, urging a change in the league's policy towards cannabis. The letter was penned by Doctors for Cannabis Regulation and signed by several other NFL players. Turley is also a member of the Doctors for Cannabis Regulation NFL steering committee. In January 2017 Turley announced the launch of Neuro Armour (now Neuro XPF), a THC-free cannabis oil that is rich in cannabidiol (CBD) and various terpenes. In March 2020 he opened a cannabis dispensary in Moreno Valley, California, operating under the Shango brand of dispensaries. Turley received criticism in March 2020 for claiming his CBD products could cure COVID-19 by boosting the immune system. The Food and Drug Administration advised him to cease making such claims on official materials from his CBD business or else he would be subject to legal action. He immediately complied with the request. Gridiron Greats Turley is a board member and active supporter of the Gridiron Greats Assistance Fund, a non-profit 501(c)(3) organization providing medical care and other forms of assistance to retired NFL players in need. Turley first became involved as an active player in 2007 when he pledged one of his game checks to the fund and challenged other players to do the same, many of whom joined in helping to raise several hundred thousand dollars. Announcing his pledge at a November 2007 press conference, Turley spoke of the debilitating football-related health problems and inadequate medical and pension benefits that many retired players face, a topic that had already been the focus of two congressional hearings earlier in the year. Turley became the first active player to publicly take up the cause, also taking NFLPA executive director Gene Upshaw to task at the time for failing to address the issue. After retiring from football, Turley continued to raise funding and awareness