bind to GABAergic neurons. In 2006, the role of GABARAP in SPS was discovered. The first case of paraneoplastic SPS was found in 1975. In 1993, antiamphiphysin was shown to play a role in paraneoplastic SPS, and seven years later antigephyrin was also found to be involved in the condition. In December 2022, singer Céline Dion announced that she is suffering from this syndrome, resulting in cancelled performances. See also Satoyoshi syndrome Hyperekplexia References Bibliography External links Stiff-Person Syndrome Information Page at NINDS Extrapyramidal and movement disorders Ailments of unknown cause Syndromes affecting the nervous system Rare syndromes