Surgical realignment Retinal Detachment repair Myringotomy (surgical procedure to relieve pressure by draining fluid from the eardrum) Non-surgical Routine monitoring Oxygen support, CPAP, Bipap, Mechanical Ventilation Physical therapy Bracing Like treatment options, the prognosis is dependent on the severity of the symptoms. Despite the various symptoms and limitations, most individuals have normal intelligence and can lead a normal life. Recent research A recent article in 2015 reported a persistent notochord in a fetus at 23 weeks of gestation. The fetus had an abnormal spine, shortened long bones and a left clubfoot. After running postmortem tests and ultrasound, the researchers believed that the fetus suffered from hypochondrogenesis. Hypochondrogenesis is caused when type II collagen is abnormally formed due to a mutation in the COL2A1 gene. Normally, the cartilaginous notochord develops into the bony vertebrae in a human body. The COL2A1 gene results in malformed type II collagen, which is essential in the transition from collagen to bone. This is the first time that researchers found a persistent notochord in a human body due to a COL2A1 mutation. Eponym It is named for Wilhelm Kniest. References Congenital disorders Skeletal disorders Autosomal dominant disorders Rare diseases