and coworkers in 1968 from a patient with isovaleric acidemia. The effects of HMB on human skeletal muscle were first discovered by Steven L. Nissen at Iowa State University in the . Nissen founded a company called Metabolic Technologies, Inc. (MTI) around the time of his discovery, which later acquired six HMB-related patents that the company has used to license the right to manufacture and incorporate HMB into dietary supplements. When it first became available commercially in the late 1990s, HMB was marketed solely as an exercise supplement to help athletes and bodybuilders build muscle. MTI subsequently developed two HMB-containing products, Juven and Revigor, to which Abbott Nutrition obtained the market rights in 2003 and 2008 respectively. Since then, Abbott has marketed Juven as a medical food and the Revigor brand of HMB as an active ingredient in food products for athletes (e.g., certain formulations of Myoplex) and other medical foods (e.g., certain formulations of Ensure). See also 3-Aminoisobutyric acid Notes Reference notes References External links Amino acid derivatives Biomolecules Bodybuilding supplements Dietary supplements Ergogenic aids Human metabolites Beta hydroxy acids Medical food Proteasome inhibitors Physiology Rehabilitation medicine Muscular disorders