acid, 2,5-isosorbide dinitrate (ISDN) can be obtained. 2,5-isosorbide dinitrate is suitable (just like its major metabolite 5-isosorbide mononitrate, ISMN) for the treatment of angina pectoris due to its vasodilator effect. Isosorbide esters Esterification of isosorbide with fatty acids gives access to isosorbide monoesters, which are useful as detergents in household cleaners, dishwashing detergents, and cosmetic preparations, because of their properties as surfactant. The likewise readily available isosorbide diesters are used as dispersants for pigments, preservatives, polymer stabilizers, as emulsifiers for cosmetics and as plasticizers for vinyl polymers (in particular polyvinyl chloride, PVC). Isosorbide dioctanoate is a diester of isosorbide and octanoic acid (obtained from palm oil, for example) and therefore made entirely from bio-based building blocks and has been used as Polysorb(R) ID 37 by Roquette Frères for some time as a particularly non-toxic product. Isosorbide ethers Isosorbide ethers (and in particular the simplest representative, 2,5-dimethylisosorbide, abbreviated DMI), are increasingly used as a renewable solvent for cosmetic and pharmaceutical preparations, as an electrolyte additive for lithium-ion accumulators [18] and as a fuel additive for diesel. Isosorbide phosphates Phosphoric acid derivatives of isosorbide are explored as an environmentally friendly alternative to halogen-containing flame retardants. So far, 1,2,5,6,9,10-hexabromocyclododecane (HBCD) has been widely used as a flame retardant in extruded polystyrene foam (XPS) in the construction and insulation sector, but it was as SVHC (substance of very high concern) banned from manufacturing and application in May 2013. Phosphorus-based isosorbide compounds, such as isosorbide bis (diphenyl phosphate) [ISTP] are considered as a replacement. ISTP is readily accessible by transesterification of isosorbide with triphenyl phosphate in the presence of potassium carbonate at 150 °C. The isosorbide-bis-diphenyl phosphate obtained in 88% yield as a yellowish oil contains about 20% dimers. The high decomposition temperature of ISTP allows a use in XPS, although the high softening effect is a drawback. The flame retardancy is particularly pronounced in the presence of sulfur-containing synergists such as bis(diphenylphosphinothionyl)disulfide (BDPS). This allows to reach the minimum requirement of fire protection (class B2) with only 3% ISTP. Polymers from Isosorbide Isosorbide has been examined as a potential platform chemical for the production of diverse polymers and resins. The hydroxy groups can be converted into the primary amino groups via the tosylates and azides or by addition of acrylonitrile followed by hydrogenation into the corresponding aminopropyl derivatives. The latter have potential for the preparation of polyurethanes, as diamines for the preparation of polyamides,