Busch Stadium, win 2006 World Series | |- | | style=";" | Cubs | style=";" | | Cubs, 7–2 | Cubs, 4–3 | | |- | | style=";" | Cubs | style=";" | 9–6 | Cubs, 5–4 | Cubs, 4–2 | | |- | | style=";" | Cardinals | style=";" | | Cardinals, 7–2 | Cubs, 4–3 | | |- |- | | style=";" | Cubs | style=";" | 9–6 | Cubs, 5–1 | Cardinals, 5–4 | | |- | | style=";" | Cardinals | style=";" | | Cardinals, 7–2 | Tie, 3–3 | Cardinals win 2011 World Series | |- | | style=";" | Cardinals | style=";" | | Cardinals, 6–2 | Cubs, 5–4 | | |- | | style=";" | Cardinals | style=";" | | Cardinals, 7–3 | Cardinals, 5–4 | MLB realignment results in 19 meetings per season starting in 2013. Cardinals lose 2013 World Series. | |- | | style=";" | Cardinals | style=";" | | Cardinals, 6–4 | Cubs, 5–4 | | |- | | style=";" | Cardinals | style=";" | | Cardinals, 7–3 | Cubs, 5–4 | Cardinals win 100 games, Cubs win 97 games, Two of the three best records in MLB that season (along with NL Central rival Pittsburgh). | |- style="background:#f2f2f2; font-weight:bold;" | 2015 NLDS | style=";" | Cubs | style=";" | 3–1 | Tie, 1–1 | Cubs, 2–0 | Only postseason meeting between the two teams since Cardinals joined the National League in 1892. |- | | style=";" | Cubs | style=";" | | Cubs, 6–3 | Cardinals, 6–4 | Cubs win 2016 World Series, their first title since 1908. | |- | | style=";" | Cubs | style=";" | | Cubs, 6–4 | Cubs, 8–1 | | |- | | style=";" | Cardinals | style=";" | | Cardinals, 6–3 | Cubs, 6–4 | | |- | | style=";" | Cardinals | style=";" | | Cardinals, 6–3 | Cubs, 6–4 | | |- |- | | Tie | 5–5 | Cubs, 2–1 | | Season shortened to 60 games (with 10 meetings) due to COVID-19 pandemic. All Cardinals' home games were played at Wrigley Field (though the Cardinals batted second) after their lone home series was postponed as a result of an outbreak among the Cardinals. | |- | | style=";" | Cardinals | style=";" | | Tie, 5–5 | Cardinals, 5–4 | | |- | | style=";" | Cardinals