as enzymes, where the catalytic site may be buried within a large protein structure. In pharmacology, steric effects determine how and at what rate a drug will interact with its target bio-molecules. See also Collision theory Reaction rate accelerate as result of steric hindrance in the Thorpe–Ingold effect Sterically induced reduction Intramolecular force Van der Waals strain, also known as steric strain References External links Stereochemistry Physical organic chemistry