The Cotton Genesis (London, British Library, Cotton MS Otho B VI) is a 4th- or 5th-century Greek Illuminated manuscript copy of the Book of Genesis. It was a luxury manuscript with many miniatures. It is one of the oldest illustrated biblical codices to survive to the modern period. Most of the manuscript was destroyed in the Cotton library fire in 1731, leaving only eighteen charred, shrunken scraps of vellum. From the remnants, the manuscript appears to have been more than 440 pages with approximately 340-360 illustrations that were framed and inserted into the text column. Many miniatures were also copied in the 17th century and are now in the Bibliothèque nationale de France in Paris (Ms. fr. 9530). Description The manuscript contains the text of the Book of Genesis on 35 parchment leaves (size about 27 x 22 cm), with numerous lacunae. The original codex contained 165 leaves, in the quarto size. It is written in uncial letters, in one column per page, in 27-30 letters per line. The nomina sacra usually are written in an abbreviated forms: ΚΣ, ΚΝ, ΘΣ, ΘΝ, for κυριος, κυριον, θεος, θεον. It contains some illustrations (e.g. Joseph with his brethren in his own house, on their return into Egypt). The miniatures were executed in a late antique style, retaining classical illusionistic qualities. Herbert L. Kessler and Kurt Weitzmann argue that the manuscript was produced in Alexandria, as it exhibits stylistic similarities to other Alexandrian works such as the Charioteer Papyrus. History of the codex According to Tischendorf it was written in the 5th century. The Cotton Genesis appears to have been used in the 1220s as the basis for the design of 110 mosaic panels in the atrium of St Mark's Basilica in Venice, presumably after it was brought to Venice following the sack of Constantinople by the Fourth Crusade in 1204. It was brought from Philippi by two Greek bishops, who presented it to King Henry VIII, whom they informed that tradition reported it to have been the identical copy which had belonged to Origen. The manuscript was acquired by Sir Robert Cotton in the 17th century. His collection passed to the British Museum. In 1731, while the codex was at Ashburnham House with the rest of the collection, it was reduced by fire to a heap of charred and shrivelled leaves. Afterwards the rest of the codex was divided in two parts.