Frist is a surname. Notable people with the surname include: Bill Frist (born 1952), American physician, businessman, and politician Patricia C. Frist, American businesswoman and philanthropist. Thomas F. Frist, Jr. (born c. 1939), American businessman Thomas F. Frist, Sr. (1910–1998), American businessman Thomas F. Frist, III, American businessman. William R. Frist, American businessman.