the meta-analyses were rarely disclosed. The 29 meta-analyses reviewed an aggregate of 509 randomized controlled trials. Of these, 318 trials reported funding sources with 219 (69%) industry funded. 132 of the 509 trials reported author disclosures of conflict of interest, with 91 studies (69%) disclosing industry financial ties with one or more authors. However, the information was seldom reflected in the meta-analyses. Only two (7%) reported funding sources and none reported author-industry ties. The authors concluded, "without acknowledgment of COI due to industry funding or author industry financial ties from RCTs included in meta-analyses, readers' understanding and appraisal of the evidence from the meta-analysis may be compromised." In 2003 researchers looked at the association between authors' published positions on the safety and efficacy in assisting with weight loss of olestra, a fat substitute manufactured by the Procter & Gamble (P&G), and their financial relationships with the food and beverage industry. They found that supportive authors were significantly more likely than critical or neutral authors to have financial relationships with P&G and all authors disclosing an affiliation with P&G were supportive. The authors of the study concluded: "Because authors' published opinions were associated with their financial relationships, obtaining noncommercial funding may be more essential to maintaining objectivity than disclosing personal financial interests." A 2005 study in the journal Nature surveyed 3247 US researchers who were all publicly funded (by the National Institutes of Health). Out of the scientists questioned, 15.5% admitted to altering design, methodology or results of their studies due to pressure of an external funding source. Regulatory capture Private funding also may be chanelled to public funders. In 2022, a news story broke following the resignation of Eric Lander, former director of the Office of Science and Technology Policy (OSTP) at the Biden Administration, that the charity of former Google executive Eric Schmidt, Schmidt Futures, paid the salary of a number employees of the OSTP. Ethics inquiries were initiated in the OSTP. Efficiency of funding The traditional measurement for efficiency of funding are publication output, citation impact, number of patents, number of PhDs awarded etc. However, the use of journal impact factor has generated a publish-or-perish culture and a theoretical model has been established whose simulations imply that peer review and over-competitive research funding foster mainstream opinion to monopoly. Calls have been made to reform research assessment, most notably in the San Francisco Declaration on Research Assessment and the