protein S levels Type II – decreased in regards to the cofactor activity of the protein Type III – decreased protein S activity: decreased free protein S levels (normal total protein S levels) Treatment In terms of treatment for protein S deficiency the following are consistent with the management (and administration of) individuals with this condition (the prognosis for inherited homozygotes is usually in line with a higher incidence of thrombosis for the affected individual): Unfractionated heparin (w/ warfarin) LMWH/Low molecular weight heparin Dabigatran Direct Factor Xa Inhibitors Graduated compressed stocking High degree of prophylaxis References Further reading External links Coagulopathies