elimination at the 2-position impossible. In order for the Hofmann product to form, elimination must occur at the 6-position. Because the proton at this position has the correct orientation relative to the leaving group, elimination can and does occur. As a result, this particular reaction produces only the Hofmann product. See also Markovnikov's rule Hofmann elimination Cope elimination References Bibliography External links Online course of chemistry English Translation of 1875 German article on 'The order of addition and of elimination of hydrogen and iodine in organic compounds' by Alexander Zaitsev. Physical organic chemistry 1875 in science