disability. Progressive liver damage, skin lesions, and brittle hair may also be seen Oto-palato-digital syndrome; facial deformities, cleft palate, hearing loss Siderius X-linked mental retardation syndrome; cleft lip and palate with intellectual disability and facial dysmorphism, caused by mutations in the histone demethylase PHF8 Simpson–Golabi–Behmel syndrome; coarse faces with protruding jaw and tongue, widened nasal bridge, and upturned nasal tip Spinal muscular atrophy caused by UBE1 gene mutation; weakness due to loss of the motor neurons of the spinal cord and brainstem Wiskott–Aldrich syndrome; eczema, thrombocytopenia, immune deficiency, and bloody diarrhea X-linked severe combined immunodeficiency (SCID); infections, usually causing death in the first years of life X-linked sideroblastic anemia; skin paleness, fatigue, dizziness and enlarged spleen and liver. See also Sex linkage X-linked dominant inheritance References External links X-linked diseases from the Wellcome Trust [Female X-linked disorders] Sex-linked recessive: MedlinePlus Medical Encyclopedia Genetics