However, only the pilot episode was aired and the series did not proceed. Lee became a busy guest actor in the 1970s, appearing on Marcus Welby, M.D.; Alias Smith and Jones; Night Gallery; Love, American Style; Fantasy Island; The Love Boat; and The Match Game. Knots Landing In 1979, Lee accepted the role of Karen Fairgate on Knots Landing, a spin-off of the highly popular Dallas. Though slow to start, the series eventually became a ratings hit and became one of the longest-running American primetime dramas ever, lasting for a total of 14 seasons from 1979–1993. Due to her long-running tenure, Lee's alter ego is often credited as being the center of the program. Television personality Joan Rivers commented that Lee was, in theory, the "First Lady of Knots Landing" during her guest appearance on The Late Show, which Rivers hosted at the time. The characters of the serial often represented what was happening in society at the time. Lee acknowledged that, saying: "Karen wanted to be a Pollyanna and wasn't ashamed of that. Remember in our society, maybe people don't remember, but remember when we could go over to other people's houses and come in through an open back door? I remember when I was a little girl and my mother and father would have people over and they'd walk into an unlocked door in our house." Lee was the only performer to appear in all of the show's 344 episodes. Although Lee was enjoying a successful career on television, her marriage to actor James Farentino was failing. Farentino and she separated around the same time Lee's onscreen husband, Don Murray, left the series. Lee thus played a single mother on Knots Landing at the same time she was becoming one in real life. Lee said that when her character took off her wedding ring in a 1982 episode, she was taking off her real wedding band. During the fall of 1982, her character met M. Patrick "Mack" MacKenzie (Kevin Dobson), who became her screen husband the following year. They would continue working together until the end of the series. Lee won the Soap Opera Digest Award for Best Lead Actress (Primetime) three times, and was also nominated for an Emmy in 1982 for "Outstanding Lead Actress in a Drama Series". In 1983, the writers/producers of Knots Landing urged her to do a storyline based on prescription drug dependency