The Killough massacre is believed to have been both the largest and last Native American attack on white settlers in East Texas. The massacre took place on October 5, 1838, near Larissa, Texas, in the northwestern part of Cherokee County. There were eighteen victims, including Isaac Killough, Sr., and his extended family (viz. the families of four sons and two daughters). They had immigrated to the Republic of Texas from Talladega County, Alabama, in 1837. Context Apparently unaware that the land made available to them was hotly disputed by the Cherokee Indians who lived in the area, Isaac Killough and his homesteaders began clearing land for crops and building homes. Only a year earlier, however, the area surrounding their settlement had been set aside for the Cherokee under a treaty negotiated and signed by Sam Houston and John Forbes. When the Republic of Texas Senate refused to ratify the treaty and then, in December 1838, formally nullified it, the Cherokee, who already thought they had conceded enough, became homicidal. The influx of Anglo settlers into lands thought to have been theirs increased Cherokee resentment, and as there was also residual bitterness among some Hispanics still loyal to Mexico, the atmosphere in the region became tense in early 1838. By the summer of that year, there were rumblings of coming insurrection from either or both of those factions, and evidence existed for collusion between them. Fearing this growing unrest, Killough with his relatives and friends fled to Nacogdoches for refuge. On condition they would leave the area after doing so, the Cherokee leaders agreed to their safe passage if they would return simply to harvest their crops. They did so. But on October 5, 1838, a band of Cherokee who had not been party to the agreement attacked the settlement. Most of the Killough group—a total of eighteen—were killed or abducted as they worked their fields. Those who survived fled for a time to Lacy's Fort on the San Antonio Road, just west of present-day Alto, Texas. According to Dallas newspaperman Charles Kilpatrick, several of the men walked into an ambush and the Native Americans then: "...shot down Isaac, Jr., Allen, Samuel and George Wood, then swept uphill into the little settlement. Isaac, Sr., fell in his front yard and Barakias Williams was killed in front of the screaming women. Eight settlers, including seven women and children, were seized by warriors