missions and the refusal of the Guaraní to be forcibly relocated led to the nullification of the treaty by the subsequent Treaty of El Pardo, signed by both countries in 1761. The opposition by the Guaraní led to the Guaraní War of 1756. The terms of the Treaty of Madrid, with a few exceptions, were re-established in the First Treaty of San Ildefonso in 1777, and that treaty was again negated in 1801. See also Treaty of Madrid (5 October 1750) Catholic Church and the Age of Discovery Spanish missions in South America References Citations Bibliography . External links Geographic Map of the Captaincy of Mato Grosso is a map that features details about the Treaty of Madrid, from c. 1800. Colonial Brazil 1750 treaties Madrid 1750 Madrid 1750 Portugal–Spain relations Portuguese colonization of the Americas Spanish colonization of the Americas Geopolitical rivalry Treaties involving territorial changes 1750 in Brazil 1750 in South America 1750 in Spain 1750 in Portugal 1750 in the Spanish Empire