He started in the St. Louis Rams’ against the Denver Broncos and collected a season-high 14 combined tackles (nine solo) and made two sacks during their 41–36 victory. On November 12, 2000, Fletcher made six solo tackles, forced a fumble, and made his first career interception during a 38–24 at the New York Giants in Week 11. Fletcher intercepted a pass by Giants’ Kerry Collins, that was intended for wide receiver Ike Hilliard, and returned it for a 12-yard gain during the third quarter. In Week 13, Fletcher recorded seven combined tackles, was credited with half a sack, and made a season-high two interceptions during a 31–24 loss against the New Orleans Saints. He made both interceptions off pass attempts by Saints’ quarterback Aaron Brooks. In Week 15, he recorded ten combined tackles (nine solo) and two sacks during a 40–29 victory against the Minnesota Vikings. His performance earned him NFC Defensive Player of the Week honors. He led the team with 193 tackles on defense and special teams, eclipsing the old franchise mark of 185 set by LB Jim Collins in 1984. Fletcher recorded 132 combined tackles (105 solo) solely on defense and made four interceptions and 5.5 sacks in 16 games and 15 starts. 2001 In 2001, Fletcher earned NFC Defensive Player of the Week honors twice and was an alternate to the pro bowl for the third straight season. In a game against the San Francisco 49ers on September 23, he led the team with a career-high 21 tackles, 15 solo. The second time was after his big performance against the New England Patriots on November 18 as he led the team with 17 tackles with one pass deflection. He forced a fumble on the Rams’ three-yard line that led to a 97-yard scoring drive to end the first half and intercepted a Tom Brady pass with 5:18 left in the third quarter for an 18-yard return. This season, the Rams made the Super Bowl XXXVI but were defeated by the Patriots 20–17, after kicker Adam Vinatieri made a game-winning 48-yard field goal as time expired. Buffalo Bills On March 6, 2002, the Buffalo Bills signed Fletcher to a five-year, $17.12 million contract that includes a signing bonus of $4 million. Starting in 2002, Fletcher started all 16 regular season games for the Bills until his last season in 2006, when he recorded a team-high 157 tackles,