medications, chemicals, or foods. Commonly known as "favism", as it can be triggered by chemicals existing naturally in broad (or fava) beans. Less common disorders Theoretically, a mutation in any of the genes on chromosome X may cause disease, but below are some notable ones, with short description of symptoms: Adrenoleukodystrophy; leads to progressive brain damage, failure of the adrenal glands and eventually death. Alport syndrome; glomerulonephritis, endstage kidney disease, and hearing loss. A minority of Alport syndrome cases are due to an autosomal recessive mutation in the gene coding for type IV collagen. Androgen insensitivity syndrome; variable degrees of undervirilization and/or infertility in XY persons of either sex Barth syndrome; metabolism distortion, delayed motor skills, stamina deficiency, hypotonia, chronic fatigue, delayed growth, cardiomyopathy, and compromised immune system. Blue cone monochromacy; low vision acuity, color blindness, photophobia, infantile nystagmus. Centronuclear myopathy; where cell nuclei are abnormally located in skeletal muscle cells. In CNM the nuclei are located at a position in the center of the cell, instead of their normal location at the periphery. Charcot–Marie–Tooth disease (CMTX2-3); disorder of nerves (neuropathy) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs but also in the hands and arms in the advanced stages of disease. Coffin–Lowry syndrome; severe intellectual disability sometimes associated with abnormalities of growth, cardiac abnormalities, kyphoscoliosis as well as auditory and visual abnormalities. Fabry disease; A lysosomal storage disease causing anhidrosis, fatigue, angiokeratomas, burning extremity pain and ocular involvement. Hunter syndrome; potentially causing hearing loss, thickening of the heart valves leading to a decline in cardiac function, obstructive airway disease, sleep apnea, and enlargement of the liver and spleen. Hypohidrotic ectodermal dysplasia, presenting with hypohidrosis, hypotrichosis, hypodontia Kabuki syndrome (the KDM6A variant); multiple congenital anomalies and intellectual disability. Spinal and bulbar muscular atrophy; muscle cramps and progressive weakness Lesch–Nyhan syndrome; neurologic dysfunction, cognitive and behavioral disturbances including self-mutilation, and uric acid overproduction (hyperuricemia) Lowe syndrome; hydrophthalmia, cataracts, intellectual disabilities, aminoaciduria, reduced renal ammonia production and vitamin D-resistant rickets Menkes disease; sparse and coarse hair, growth failure, and deterioration of the nervous system Nasodigitoacoustic syndrome; misshaped nose, brachydactyly of the distal phalanges, sensorineural deafness Nonsyndromic deafness; hearing loss Norrie disease; cataracts, leukocoria along with other developmental issues in the eye Occipital horn syndrome; deformations in the skeleton Ocular albinism; lack of pigmentation in the eye Ornithine transcarbamylase deficiency; developmental delay and intellectual