Denise Darvall (27 February 19423 December 1967) was the donor in the world's first successful human heart transplant, performed at Groote Schuur Hospital, South Africa, by a team of surgeons led by Christiaan Barnard. Accident and death Injuries Denise Darvall was seriously injured in a car accident on Main Road in Observatory, Cape Town. She and her family were visiting friends for afternoon tea and went shopping for cake. She and her mother, Myrtle Ann Darvall, were run over by salesman and police reservist Frederick Prins, who failed to see them. This was due to a large truck that obscured his view of them, and their view of his car. Her mother died immediately. Denise Darvall sustained a skull fracture and severe head injuries after the car flung her across the road; her head hit the wheel cap of her car. She required life support to remain alive, and was essentially brain dead by the time she made it into the hospital. At 9 p.m. on the day of the accident, the resuscitation team stopped attempts to revive her. Father gives permission Edward Darvall arranged for his fourteen-year-old son, who had witnessed the accident, to be taken away from the hospital. The 66-year-old Edward was also given a sedative, and he waited while doctor's attempted to save his daughter. Two doctors, Coert Venter and Bertie Bosman, informed him that there was nothing further they could do for Denise. Bosman explained that there was a man in the hospital they might be able to help, and asked Edward if he would consider allowing them to transplant Denise's heart. Edward Darvall later said that, after thinking about his daughter for four minutes, he reached his decision and gave permission. Declaration of death Surgeons had a serious ethical problem because death then could only be declared by whole-body standards. The Harvard Criteria of brain death were not developed until 1968, nor were they adopted in South Africa or elsewhere for some years. The problem in this case was that, although Denise's brain was damaged, her heart was healthy. Various reports over the years attributed conflicting reasons for her heart stopping. For 40 years, Marius Barnard kept a secret: rather than wait for her heart to stop beating, his brother, Christiaan Barnard, who led the transplant team, had injected potassium into Denise's heart to paralyze it at Marius's urging. This rendered her technically dead