advances in arts and sciences in Renaissance Italy. She made certain that her children were educated in the spirit of the Italian Renaissance, also helped by her Italian confessor, Cristoforo Numai from Forlì. She commissioned books specifically for them and she taught Francis Italian and Spanish. When Louis XII became ill in 1505, he determined that Francis should succeed him and that both Louise and his wife Anne of Brittany should be part of the regency council. He recovered and Francis became a favourite of the king, who eventually gave him his daughter Claude of France in marriage on 8 May 1514. Following the marriage, Louis XII designated Francis as his heir. Mother of the King With the death of Louis XII on 1 January 1515, Francis became king of France. On 4 February 1515, Louise was named Duchess of Angoulême, and on 15 April 1524, Duchess of Anjou. The Bourbon inheritance Her mother having been one of the sisters of the last dukes of the main branch of Bourbon, after the death of Suzanne, Duchess of Bourbon, in 1521, Louise, on basis of proximity of blood, advanced claims to the Duchy of Auvergne and other possessions of the Bourbons. This led her (supported by her son) in rivalry against Charles III, Duke of Bourbon, Suzanne's widower, whom she proposed to marry in order to settle the Bourbon inheritance issue. When her suit was insultingly rejected by Charles, Louise instigated efforts to undermine him. This led to Charles' exile and his attempt to regain his lost status by waging war against the King. He died in 1527 having failed to regain his lost lands and titles. Louise recovered Auvergne from confiscations and became duchess in the name of her son. Regent Louise of Savoy remained politically active on behalf of her son in the early years of his reign especially. During his absences, she acted as regent on his behalf. Louise served as the Regent of France in 1515, during the king's war in Italy, and again from 1525 to 1526, when the king was at war and during his time as a prisoner in Spain. In 1524, she sent one of her servants, Jean-Joachim de Passano, to London to open unofficial negotiations with Cardinal Wolsey for a peace treaty; the negotiations were not a success, although they may have prepared the ground for the Treaty of the More the