following year. She initiated friendly relations with the Ottoman Empire by sending a mission to Suleiman the Magnificent requesting assistance, but the mission was lost on its way in Bosnia. In December 1525, a second mission was sent, led by John Frangipani, which managed to reach Constantinople, the Ottoman capital, with secret letters asking for the deliverance of King Francis I and an attack on the Habsburg. Frangipani returned with a positive answer from Suleiman, on 6 February 1526, initiating the first steps of a Franco-Ottoman alliance. She was the principal negotiator for the Treaty of Cambrai between France and the Holy Roman Empire, which concluded on 3 August 1529. That treaty, called "the Ladies' Peace", put an end to the second Italian war between the head of the Valois dynasty, Francis I of France, and the head of the Habsburg dynasty, Charles V, Holy Roman Emperor. The Treaty temporarily confirmed Habsburg hegemony in Italy. The treaty was signed by Louise of Savoy for France and her sister-in-law, Margaret of Austria, for the Holy Roman Empire. Death Louise of Savoy died on 22 September 1531, in Grez-sur-Loing of the plague. Her remains were entombed at Saint-Denis in Paris. After her death, her lands, including Auvergne, merged in the crown. Through her daughter Marguerite (Queen of Navarre) and her granddaughter Jeanne d'Albret, she is the ancestress of the Bourbon kings of France, as her great-grandson, Henry of Navarre, succeeded as Henry IV of France. Ancestors References Sources 1476 births 1531 deaths Burials at the Basilica of Saint-Denis Regents of France Duchesses of Anjou Duchesses of Nemours Dukes of Auvergne 2 Princesses of Savoy 15th-century French women 15th-century French people 16th-century French women 16th-century women rulers Auvergne, Duchess of, Louise of Savoy 16th-century peers of France 16th-century deaths from plague (disease)