were conducted to assess and collect physical and functional measurements, as well as blood to replenish the WHI biospecimen repository and determine current CBC parameters for these participants. The LLS completed its in-person visits and blood collections in May 2013. A large subset of the LLS participants (n ≈ 7400) were further enrolled in the Objective Physical Activity and Cardiovascular Health in Women (OPACH) study, the purpose of which was to assess physical activity in women capable of ambulation. These women were asked to maintain a week-long sleep log, wear an accelerometer for a week, and keep track of falls on a month basis for one year. The goal was to establish a stronger correlation between physical activity and cardiovascular disease and total mortality. COcoa Supplement and Multivitamin Outcomes Study (COSMOS) The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) at Brigham and Women's Hospital and the Fred Hutchinson Cancer Research Center (Seattle, WA) was a four-year clinical trial with more than 21,000 women and men, recruited from across the U.S. The study was supported by Mars and Pfizer. The objective of the study was to investigate whether either cocoa flavanols (600 mg/day) or a common multivitamin affects the risk of developing heart disease, stroke, and cancer. First results showed no effect on the pre-registered primary endpoints (incidences of heart disease and cancer), but they did show an effect on secondary endpoints with a reduction in heart disease mortality for cocoa flavanols and a reduction of lung cancer risk for multivitamins. Women's Health Initiative Strong & Healthy (WHISH) The Women's Health Initiative Strong and Healthy Study (WHISH), started in 2015 and expected to last four years, seeks to examine the impact of physical activity in older women on certain outcomes such as heart disease and metrics including maintaining an independent lifestyle. The study has enrolled nearly 50,000 participants as of October 2016, whose assigned interventions will include varying physical activity routines, which are monitored by mail and via phone, using an interactive voice response (IVR) system. Other ancillary studies Public health investigators and biostatisticians can apply to use WHI study data in conjunction with their investigations. As of June 2013, nearly 450 Ancillary Studies have been proposed. Newly generated data from these Ancillary Studies must be submitted to the WHI, which in turn provides a richer data resource for subsequent studies. In addition to the study data, data from genome-wide association