Portola may refer to: Portola (album), a 1998 album by Rose Melberg Portola, California Portola, San Francisco, California People with the surname Gaspar de Portolá (ca. 1717-aft.1784), Spanish soldier, first governor of the Californias (Baja and Alta), explorer and founder of San Diego and Monterey See also Portola Hills, California Portola Valley, California Portola Pharmaceuticals