drugs such as painkillers or recreational drugs are used. The use of pesticides to self-poison is the most common method used in some countries. Poisoning through the means of toxic plants is usually slow and painful. Pesticide , worldwide, around 30% of suicides were from pesticide poisonings. The use of this method varies markedly in different areas of the world, from 0.9% in Europe to about 50% in the Pacific region. In the US, pesticide poisoning is used in about 12 suicides per year. Method restriction has been an effective way to reduce suicide by poisoning in many countries. In Finland, limiting access to parathion in the 1960s resulted in a rapid decline in both poisoning-related suicides and total suicide deaths for several years, and a slower decline in subsequent years. In Sri Lanka, both suicide by pesticide and total suicides declined after first toxicity class I and later class II endosulfan were banned. Overall suicide deaths were cut by 70%, with 93,000 lives saved over 20 years as a result of banning these pesticides. In Korea, banning a single pesticide, paraquat, halved the number of suicides by pesticide poisoning and reduced the total number of suicides in that country. Drug overdose A drug overdose involves taking a dose of a drug that exceeds safe levels. In the UK (England and Wales) until 2013, a drug overdose was the most common suicide method in females. In 2019 in males the percentage is 16%. Self-poisoning accounts for the highest number of non-fatal suicide attempts. Overdose attempts using painkillers are among the most common, due to their easy availability over-the-counter. Paracetamol is the most widely used analgesic worldwide and is commonly used in overdose attempts. Paracetamol poisoning is a common cause of acute liver failure. In the United States about 60% of suicide attempts and 14% of suicide deaths involve drug overdoses. The risk of death in suicide attempts involving overdose is about 2%. Carbon monoxide A particular type of poisoning involves the inhalation of high levels of carbon monoxide (CO). Death usually occurs through hypoxia. A nonfatal attempt can result in memory loss and other symptoms. Carbon monoxide is a colorless and odorless gas, so its presence cannot be detected by sight or smell. It acts by binding preferentially to the hemoglobin in the bloodstream, displacing oxygen molecules and progressively deoxygenating the blood, eventually resulting in the failure of cellular respiration