in which they were due to play the and the , however, the emergence of the omicron variant of COVID-19 led to travel restrictions being implemented by UK and EU authorities, meaning the fixtures had to be postponed. 34 players and staff arrived back in Ireland on 1 December 2021 and immediately entered 10 days of mandatory self-isolation. 14 players and staff who had tested positive for COVID-19 had to remain in South Africa. In the wake of this disruption for Munster and other clubs, and with Munster's opening Champions Cup fixture away to Wasps falling on 12 December, the EPCR extended the deadline for registering players for the tournament to 8 December, meaning Munster could look to supplement their squad with short-term signings, and 22 players were subsequently registered with the province's Champions Cup squad. A depleted Munster squad made up of internationals who'd been away with Ireland during the Autumn tests, academy players and members of the national and provincial talent squads travelled over to England to face Wasps on their opening Champions Cup fixture on 12 December 2021. The team, which featured 12 debutantes, pulled off one of the great Munster away victories, defeating their opponents 35–14 in a thrilling contest in front of a large contingent of Munster fans who had made the journey to Coventry. Munster made it back-to-back wins in the Champions Cup with a gritty 19–13 win at home against French club Castres on 18 December 2021, with a 58th minute try from number 8 Jack O'Donoghue and 14 points off the tee from fly-half Ben Healy being enough for the province to see off their opposition. In the reverse fixture against Castres in round 3 of the Champions Cup on 14 January 2022, Munster earned a 16–13 away win thanks to a 77th minute try from Gavin Coombes, converted by rookie fly-half Jack Crowley, who was faultless off the kicking tee in his first European start for the province. The win secured a place in the knockout stage of the tournament for Munster. Nine days later, Munster followed up their away win against Castres with a 45–7 home win against Wasps, with the tries coming from Jeremy Loughman, Conor Murray, Jack O'Donoghue, who was player of the match on the occasion of his 150th cap for Munster, Rory Scannell and Simon Zebo, who scored a brace to become Munster's all-time leading try-scorer