Eve Robbins in the 2001 USA Cable movie Hitched. In 2001 she presented the I Love 1990 segment of the BBC's popular I Love 1990s series. There is speculation that she (and Phoebe Augustine, who played her friend Ronette in Twin Peaks) appeared in David Lynch's Mulholland Drive (2001). Many online databases even list them as appearing uncredited in the movie, but it's unknown if it's actually them or actresses who look similar to Laura and Ronette, and it has never been confirmed either way. She played the leading role of Elinore Murphy in Children on Their Birthdays (2002), based on the short story of the same title by Truman Capote. In the 2003 television series Kingpin, she played the role of Marlene Cadena opposite Yancey Arias and Bobby Cannavale. In 2004 Lee was the original choice for the role of Mary-Alice Young on Desperate Housewives. It would have been the second time she would have played a dead character on a series; however, the producers ultimately chose to replace her with Brenda Strong, as producers thought that Lee was not right for the part. Strong commented on the casting change for her character, explaining, "I think it was a conceptual shift ... There certainly wasn't something wrong with what [Lee] did. It was just that instead of vanilla they wanted chocolate, and I happened to be chocolate." 2005—present: Return to television and Independent films In 2005–06, she played the recurring role of Ellie Harp, the biological mother of Peyton Sawyer (played by Hilarie Burton), who battles breast cancer, on the third season of the WB Network series One Tree Hill. In 2007 and 2008 Lee appeared on the ABC dramedy Dirty Sexy Money as Andrea Smithson, the mother of Brian Darling's (Glenn Fitzgerald) illegitimate child. Lee, along with several other Twin Peaks cast members, guest starred in a special Twin Peaks-themed episode of Psych titled "Dual Spires." Other cast members reunited with Lee included Sherilyn Fenn (Audrey Horne), Dana Ashbrook (Bobby Briggs), Ray Wise (Leland Palmer), Lenny Von Dohlen (Harold Smith), Robyn Lively (Lana Budding Milford), and Catherine E. Coulson (The Log Lady). In 2010 she appeared in a supporting role as April in Debra Granik's Winter's Bone (which won best picture at the Sundance Film Festival in 2010). The film is about a seventeen-year-old girl (Jennifer Lawrence) in the rural Ozarks, caring for her mentally-ill mother and her