unsuitability of the breed as a pet in urban situations, prices in China for the best dogs had fallen to about $2,000, and both lower quality and crossbreed dogs were being abandoned. In 2011, a DNA study concluded that there was a genetic relationship between the Tibetan mastiff and the Great Pyrenees, Bernese Mountain Dog, Rottweiler and Saint Bernard, and that these large breed dogs are probably partially descended from the Tibetan Mastiff. In 2014, a study added the Leonberger to the list of possible relatives. Admixture with an unknown wolf-like canid The Tibetan Mastiff was able to adapt to the extreme highland conditions of the Tibetan Plateau very quickly compared with other mammals such as the yak, Tibetan antelope, snow leopard, and the wild boar. The Tibetan mastiff's ability to avoid hypoxia in high altitudes, due to its higher hemoglobin levels compared with low-altitude dogs, was due to prehistoric interbreeding. In 2020, a genomic analysis indicates that a ghost population of an unknown wolf-like canid which is deeply-diverged from modern Holarctic wolves and dogs has contributed the EPAS1 allele found in both Himalayan wolves and dogs, and this allows them to live in high altitudes. Gallery Popular culture A Tibetan Mastiff named "Max" is the central antagonist in the 1993 horror film Man's Best Friend. At least five different dogs were used in filming. A Tibetan Mastiff is the subject of the 2011 animated film The Tibetan Dog. Mouse, a "Tibetan Temple dog" (a semi-divine creature that closely resembles a Mastiff), is the canine companion of the titular character of the Dresden Files book series. The animated film Rock Dog featured two Tibetan Mastiffs named "Bodi" and "Khampa" (voiced by Luke Wilson and J. K. Simmons, respectively). In the 2018 animated television series, Craig of the Creek, the character Wildernessa rides a Tibetan Mastiff, Cheesesticks. In the 2011 film Old Dog by director Pema Tseden, the Tibetan Mastiff of a herder family is coveted by several characters to be traded to rich Han Chinese in the eastern part of the country. The 2019 video game Indivisible features Lanshi, a Tibetan Mastiff, as a playable character. The 2019 manga Ginga Densetsu Noah features three Tibetan Mastiffs as the main antagonists. The 2020 video game Ghost of Tsushima, Tibetan Mastiff is also known Bankhar Dog, were introduced as guard dog of Mongol army. The Pokémon character Mabosstiff, first featured in Scarlet