at the Queen's Club Championships where he defeated Benoît Paire in the first round but lost in the second to the 1st seed, Matteo Berrettini, in straight sets. At Wimbledon he received a wildcard. He lost in the third round to Denis Shapovalov, after defeating 24th seed Nikoloz Basilashvili and qualifier Oscar Otte. Murray entered into the men's singles and men's doubles at the 2020 Summer Olympics as the two-time defending champion. Murray was drawn against world no. 15 Canadian Félix Auger-Aliassime, but he withdrew before his first-round singles match due to a quadriceps strain, electing to remain in the doubles match. Murray was replaced by Australian Max Purcell, who went on to defeat Auger-Aliassime. Murray, along with partner Joe Salisbury, reached the quarter-finals of the men's doubles event before losing to the Croatian pair and eventual silver medallists Marin Čilić and Ivan Dodig, after defeating French pair Nicolas Mahut and Pierre-Hugues Herbert in the first round, and German pair Kevin Krawietz and Tim Pütz in the second. Murray played two events on the US circuit. At the 2021 Western & Southern Open, Murray won as a wildcard in straight sets against Richard Gasquet before losing to Hubert Hurkacz in the second round. At the 2021 Winston-Salem Open, Murray entered as a wildcard again and won in straight sets against Noah Rubin (a replacement for Nick Kyrgios who withdrew shortly before the start of the match), in the first round, before losing to Frances Tiafoe in the second. At the US Open, he lost to Stefanos Tsitsipas in five sets in the first round. The match was controversial, with Murray accusing Tsitsipas of cheating, in reference to an eight-minute bathroom break that was had by Tsitsipas during the match. Murray subsequently entered the 2021 Open de Rennes, an event on the ATP Challenger Tour after accepting a wildcard. He defeated Yannick Maden in the first round in straight sets, but lost in three sets to Roman Safiullin. Murray then reached the quarterfinal of the Moselle Open as a wildcard only losing out to the eventual champion and top seed, Poland's Hubert Hurkacz. Murray lost also as a wildcard in the round of 16 to the 2nd seed and eventual champion Casper Ruud at the 2021 San Diego Open. He received another wildcard for the Indian Wells Masters, where he reached the third round and was beaten by Alexander Zverev. He