patients and in significant amount of irritable bowel syndrome patients compared to those with ulcerative colitis or otherwise healthy controls. One study concluded that MAP "may act as a causative agent, have a role in the context of secondary infection, which may exacerbate the disease, or represent non-pathogenic colonisation." The Crohns MAP Vaccine is an experimental vaccine based on this hypothesis. Genome The genome of MAP strain K-10 was sequenced in 2005 and found to consist of a single circular chromosome of 4,829,781 base pairs, and to encode 4,350 predicted ORFs, 45 tRNAs, and one rRNA operon. See also Zoonosis References External links Type strain of Mycobacterium avium subspecies paratuberculosis at BacDive - the Bacterial Diversity Metadatabase avium paratuberculosis Subspecies