lethargy, illusions, changes in visual perception, delirium, psychosis and anterograde amnesia - along with the afore-mentioned hallucinations and sensory distortions. These compounds also induce a profound mydriasis and suppress eye saccades, resulting in considerable degradation of visual acuity, often to the point of functional blindness. This may persist, to a reduced degree, for days. The combined effect may result in a panic state in the user, a particularly dangerous situation in someone temporarily deprived of useful vision; users are prone to serious accidental injury. Scopolamine induces respiratory depression at hallucinogenic doses. The combination of anesthesia (in the hospital) and Datura is usually fatal due to combined respiratory depression. Seizures as well as fevers as high as have been reported. In popular culture The American artist Georgia O'Keeffe (1887–1986) painted "jimson weed" several times. She was fond of the flowers, which grew wild around her New Mexico house. These paintings of the exotic white pinwheel blooms, hugely magnified, are among her most familiar works. In 2014 one such painting sold for $44 million, a record price for a female artist's work. Given the location of O'Keeffe's residence in the New Mexico desert, it is likely that she saw 'western' jimson weed. The plant is an element of Hunter S. Thompson's 1971 roman à clef novel, Fear and Loathing in Las Vegas: A Savage Journey to the Heart of the American Dream. In part 2, chapter 5 of the book, a jimsonweed experience is recounted by the character Dr. Gonzo as described here: "Last Christmas somebody gave me a whole Jimson weed – the root must have weighed two pounds; enough for a year – but I ate the whole goddamn thing in about twenty minutes... Luckily, I vomited most of it right back up. But even so, I went blind for three days. Christ I couldn't even walk! My whole body turned to wax. I was such a mess that they had to haul me back to the ranch house in a wheelbarrow... they said I was trying to talk, but I sounded like a raccoon." Due to the fact that Dr. Gonzo presumably lived in Los Angeles, California during this time, this encounter was likely also with the "western jimsonweed" species as well. It could have also been Datura Innoxia, but since the author has passed, we may never know which he intended. References External links International Brugmansia and Datura