Pope Ormisda and Pope Silverio (the only case of two popes father and son), today patrons of the city. Medieval age After the fall of the Western Roman Empire, Frosinone was destroyed several times by foreign invaders; in the early Middle Ages it was an agricultural center of the Duchy of Rome. In the 13th century it became the capital of a duchy assigned to the Gaetani, from that century it was occasionally the seat of the rector of Campagna and Marittima, together with other cities of the papal province such as Ferentino, Anagni and Priverno. In 1350, it was damaged by an earthquake. At the beginning of the 14th century the city was dominated by the nearby and powerful Alatri, in turn conquered by Francesco de Ceccano and his Ceccanesi troops for thirty years. Modern age In the 16th century it was devastated by the Landsknecht, who brought the plague there, immediately followed by French and Florentine troops, at the same time as the Sack of Rome. The fortress, destroyed, was rebuilt; whose main entrance portal would have been designed by Michelangelo. New destruction occurred with the occupation by the Spanish troops at war against Pope Paul IV in 1556: its fortress was strategically important for the control of the whole Sacco valley and for the defense of Rome. Following the treaty of Cave (1557) the residence of the pontifical governors of the province of Campagna and Marittima was definitively fixed in Frosinone; the Campagna e Marittima will then take the name of the Apostolic Delegation of Frosinone. Frosinone steadily expanded its population in modern times, passing from around 2,000 people in the mid-17th century to the over 10,000 it had at the Unification of Italy (late 19th century). At the same time a new architectural and urban development began, with the construction or renovation of monuments and places of worship, and in the nineteenth century the construction of new important roads, on all the Via Nova (current Corso della Repubblica) and Viale Roma, new access to the city. Worthy of note was the attitude of the Frosinone population during the French occupation and the Roman Republic, to which two Frosinone people, Giuseppe De Matthaeis and Luigi Angeloni, who became Tribunes of the Republic adhered: the population, around 1798, rebelled against the French troops and for this reason the city was put to fire and sword and sacked (the