demonstrated in 1910 that poliomyelitis is due to a filterable virus Félix d'Herelle discovered in 1917 the bacteriophage, a virus that spread only inside bacteria Jules Bordet received the Nobel prize in 1919 for his discoveries on immunity, especially the implication of antibodies and the complement system′s mechanisms of action Charles Nicolle received the Nobel prize in 1928 for explaining how typhus is transmitted, especially the role of the louse Jean Laigret developed in 1932 the first vaccine for yellow fever André Lwoff established in 1951 the existence of proviruses, a work honored by the 1965 Nobel Prize Jacques Monod and Francois Jacob discovered the mechanism of genes' transcription regulation, a work honored by the 1965 Nobel Prize Pierre Lépine developed in 1955 one of the first anti-polio vaccines Jean-Pierre Changeux isolated in 1970 the first receptor to a neurotransmitter, the acetylcholine receptor. Luc Montagnier, Françoise Barré-Sinoussi and colleagues discovered the two HIV viruses that cause AIDS in 1983 and 1985; Montagnier and Barré-Sinoussi were honored by the 2008 Nobel Prize A new age of preventive medicine in France was made possible by the Institut Pasteur's (early 20th century) development of vaccines for tuberculosis, diphtheria, tetanus, yellow fever and poliomyelitis. The discovery and use of sulfonamides in treating infections were another of its earlier breakthroughs. Some researchers discovered antitoxins, while Daniel Bovet received the 1957 Nobel Prize for his discoveries on synthetic anti-histamines and curarizing compounds. Since World War II, Pasteur researchers have focused on molecular biology. Their achievements were recognized in 1965, when the Nobel Prize was shared by François Jacob, Jacques Monod and André Lwoff for their work on the regulation of viruses. In 1985, the first human vaccine obtained by genetic engineering from animal cells, the vaccine against hepatitis B, was developed by Pierre Tiollais and collaborators. Opening The center against rabies, directed by Jacques-Joseph Grancher and Émile Roux, had become so overcrowded that it became necessary to build a structure that Pasteur had been calling with the name "Institute Pasteur" long before it was even built. Pasteur delegated the task of the project and of creating the new building, situated on rue Dutot, to two of his colleagues, Grancher and Emile Duclaux. From the beginning, the Institute experienced economical difficulties for which it needed the help of the government, some foreign rulers, and Madame Boucicaut, but this aid did not affect its independence. The statutes drawn