for hyperplastic candidiasis is "candidal leukoplakia". This term is a largely historical synonym for this subtype of candidiasis, rather than a true leukoplakia. Indeed, it can be clinically indistinguishable from true leukoplakia, but tissue biopsy shows candidal hyphae invading the epithelium. Some sources use this term to describe leukoplakia lesions that become colonized secondarily by Candida species, thereby distinguishing it from hyperplastic candidiasis. It is known that Candida resides more readily in mucosa that is altered, such as may occur with dysplasia and hyperkeratosis in an area of leukoplakia. Associated lesions Candida-associated lesions are primary oral candidiases (confined to the mouth), where the causes are thought to be multiple. For example, bacteria as well as Candida species may be involved in these lesions. Frequently, antifungal therapy alone does not permanently resolve these lesions, but rather the underlying predisposing factors must be addressed, in addition to treating the candidiasis. Angular cheilitis Angular cheilitis is inflammation at the corners (angles) of the mouth, very commonly involving Candida species, when sometimes the terms "Candida-associated angular cheilitis", or less commonly "monilial perlèche" are used. Candida organisms alone are responsible for about 20% of cases, and a mixed infection of C. albicans and Staphylococcus aureus for about 60% of cases. Signs and symptoms include soreness, erythema (redness), and fissuring of one, or more commonly both the angles of the mouth, with edema (swelling) seen intraorally on the commissures (inside the corners of the mouth). Angular cheilitis generally occurs in elderly people and is associated with denture related stomatitis. Denture-related stomatitis This term refers to a mild inflammation and erythema of the mucosa beneath a denture, usually an upper denture in elderly edentulous individuals (with no natural teeth remaining). Some report that up to 65% of denture wearers have this condition to some degree. About 90% of cases are associated with Candida species, where sometimes the terms "Candida-associated denture stomatitis", or "Candida-associated denture-induced stomatitis" (CADIS), are used. Some sources state that this is by far the most common form of oral candidiasis. Although this condition is also known as "denture sore mouth", there is rarely any pain. Candida is associated with about 90% of cases of denture related stomatitis. Median rhomboid glossitis This is an elliptical or rhomboid lesion in the center of the dorsal tongue, just anterior (in front) of the circumvallate papillae. The area is depapillated, reddened (or red and white) and rarely painful.