30-60% of all newborns with a congenital heart defect, or about 2-6 per 1000 births. During heart formation, when the heart begins life as a hollow tube, it begins to partition, forming septa. If this does not occur properly it can lead to an opening being left within the ventricular septum. It is debatable whether all those defects are true heart defects, or if some of them are normal phenomena, since most of the trabecular VSDs close spontaneously. Prospective studies give a prevalence of 2-5 per 100 births of trabecular VSDs that close shortly after birth in 80-90% of the cases. Famous people who had ventricular septal defect Madhubala (1933–69), Indian actress. Died at age 36. XXXTentacion (1998-2018), American rapper and singer-songwriter. Died at age 20. See also Atrial septal defect Atrioventricular septal defect Cardiac output Congenital heart disease Heart sounds Pulmonary hypertension References External links Congenital heart defects