Child by Michelangelo to Bruges in 1506, and the arrival of Raphael's tapestry cartoons to Brussels in 1517, which were widely seen while in the city. Although the influence of Italian art was soon widespread across the north, it in turn had drawn on the 15th-century northern painters, with Michelangelo's Madonna based on a type developed by Hans Memling. Netherlandish painting ends in the narrowest sense with the death of Gerard David in 1523. A number of mid- and late-16th-century artists maintained many of the conventions, and they are frequently but not always associated with the school. The style of these painters is often dramatically at odds with that of the first generation of artists. In the early 16th century, artists began to explore illusionistic depictions of three dimensions. The painting of the early 16th century can be seen as leading directly from the artistic innovations and iconography of the previous century, with some painters, following the traditional and established formats and symbolism of the previous century, continuing to produce copies of previously painted works. Others came under the influence of Renaissance humanism, turning towards secular narrative cycles, as biblical imagery was blended with mythological themes. A full break from the mid-15th-century style and subject matter was not seen until the development of Northern Mannerism around 1590. There was considerable overlap, and the early- to mid-16th-century innovations can be tied to the Mannerist style, including naturalistic secular portraiture, the depiction of ordinary (as opposed to courtly) life, and the development of elaborate landscapes and cityscapes that were more than background views. Chronology The origins of the Early Netherlandish school lie in the miniature paintings of the late Gothic period. This was first seen in manuscript illumination, which after 1380 conveyed new levels of realism, perspective and skill in rendering colour, peaking with the Limbourg brothers and the Netherlandish artist known as Hand G, to whom the most significant leaves of the Turin-Milan Hours are usually attributed. Although his identity has not been definitively established, Hand G, who contributed c. 1420, is thought to have been either Jan van Eyck or his brother Hubert. According to Georges Hulin de Loo, Hand G's contributions to the Turin-Milan Hours "constitute the most marvelous group of paintings that have ever decorated any book, and, for their period, the most astounding work known to the history of art". Jan van Eyck's use of oil as