U.S. Route 65 (US 65) is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S. Route 425 in Clayton, Louisiana. The northern terminus is at Interstate 35 just south of Interstate 90 in Albert Lea, Minnesota. Parts of its modern route in Iowa and historic route in Minnesota follow the old Jefferson Highway. Route description Louisiana U.S. 65 begins in Clayton, Louisiana and proceeds northward to Waterproof, St. Joseph, and Newellton, all in Tensas Parish. At Newellton, it intersects with Louisiana State Highway 4 coming from the west. In Tallulah, it intersects Interstate 20, and approximately 30 miles north of this intersection it enters Arkansas. Arkansas US 65 enters the southeast corner of Arkansas just north of Gassoway, Louisiana. It is designated as part of Arkansas' Great River Road from this point north through Lake Village, McGehee, and Dumas. The Great River Road continues east onto US 165, while US 65 continues northwest to Pine Bluff. US 65 originally entered Pine Bluff traveling northwest along Harding Avenue, turning north along Ohio Street, then west through downtown along 5th and 6th Avenues, where northbound traffic used 5th and southbound traffic used 6th, before converging onto 6th Avenue west of downtown. The highway then turned north along Blake Street and followed Dollarway Road, now designated Arkansas Highway 365, northwest into White Hall. US 65 was later relocated to a bypass corridor on the north side of Pine Bluff, dubbed the Downtown Expressway. With the completion of the Interstate 530 bypass on the south side of Pine Bluff, US 65 was rerouted along Interstate 530, and the Downtown Expressway was resigned US 65 Business. The original US 65 between Pine Bluff and Conway is now signed Arkansas Highway 365. US 65 originally entered Little Rock via what was then Confederate Boulevard (now Springer Boulevard), turning west onto Roosevelt Road, then routing northbound traffic onto Scott Street (with southbound traffic using Main Street one block to the west), and crossing the Arkansas River concurrently with US 67, US 167, and US 70 along the Main Street Bridge to Main Street in North Little Rock. The highway in Little Rock was eventually relocated five blocks west of Main Street to Broadway, where it crossed the Arkansas River via the Broadway Bridge. It was finally relocated east along Interstate 30. US 65 originally entered