from 2004 to 2010, he co-anchored Para Sa'yo, Bayan, which aired weekly on DZMM. In July 12, 2010, Kabayan returned on air with de Castro as its anchor once again. In November 8, 2010, he returned as an anchor of TV Patrol alongside Korina Sanchez and Ted Failon, with his second stint lasting until October 7, 2021. On January 10, 2011, he started co-anchoring Radyo Patrol Balita: Alas Siyete (later renamed TeleBalita and TeleRadyo Balita in 2020) as it was combined with Kabayan. He had been a staunch critic of almost all programs of President Benigno Aquino III, who has criticized former President Arroyo, de Castro's running mate in the 2004 elections. He has been known to fire tirades against Aquino throughout Aquino's presidency (which ended in May 2016). During the administration of President Rodrigo Duterte, however, he became meek as former President Arroyo had close ties with Duterte. De Castro has been criticized for perceived misogyny, homophobia and transphobia in live television. In 2018, he was being eyed by the Duterte administration for a possible return in politics under the new administration. De Castro supports the Philippine Drug War. De Castro, along with Persida Acosta, amplified the possibility of Dengvaxia vaccination, which began during former President Aquino's term, as the cause of death of children in the Philippines. It was later proven by the World Health Organization and the Philippine Department of Health that Dengvaxia is safe and that the initial deaths of children were not connected with Dengvaxia. Various organizations have blamed de Castro and Acosta for their misinformation which led to the deaths of numerous Filipino youths due to a "vaccination scare campaign". On November 8, 2021, after backing out of another Senate run, De Castro returned to ABS-CBN and resumed anchoring both TeleRadyo Balita and Kabayan on TeleRadyo and Kapamilya Channel. He also became the host of the new public affairs program KBYN: Kaagapay ng Bayan on Kapamilya Channel, TeleRadyo and A2Z. On January 9, 2023, he returned to TV Patrol for his third stint, joining Bernadette Sembrano, Henry Omaga-Diaz and Karen Davila, coinciding with the celebration of the Feast of the Black Nazarene. Political career Senate career (2001–2004) In the 2001 Philippine Senate election, de Castro garnered the most votes and was the top-notcher for that year, garnering over 16.2 million votes running as an Independent under the Puwersa ng Masa coalition, the opposition coalition