Mantegna's Entombment. By the early 16th century, the reputation of the northern masters was such that there was an established north–south trade in their works, although many of the paintings or objects sent south were by lesser artists and of lower quality. Innovations introduced in the north and adopted in Italy included the setting of figures in domestic interiors and the viewing of interiors from multiple vantage points, through openings such as doors or windows. Hugo van der Goes' Portinari Altarpiece, in Florence's Uffizi, played an important role in introducing Florentine painters to trends from the north, and artists like Giovanni Bellini came under the influence of northern painters working in Italy. Memling successfully merged the two styles, exemplified in his Virgin and Child with Two Angels. By the mid-16th-century, however, Netherlandish art was seen as crude; Michelangelo claimed it was appealing only to "monks and friars". At this point northern art began to fall almost completely out of favour in Italy. By the 17th century, when Bruges had lost its prestige and position as the pre-eminent European trading city (the rivers silted and ports were forced to close), the Italians dominated European art. Destruction and dispersal Iconoclasm Religious images came under close scrutiny as actually or potentially idolatrous from the start of the Protestant Reformation in the 1520s. Martin Luther accepted some imagery, but few Early Netherlandish paintings met his criteria. Andreas Karlstadt, Huldrych Zwingli and John Calvin were wholly opposed to public religious images, above all in churches, and Calvinism soon became the dominant force in Netherlandish Protestantism. From 1520, outbursts of reformist iconoclasm broke out across much of Northern Europe. These might be official and peaceable, as in England under the Tudors and the English Commonwealth, or unofficial and often violent, as in the Beeldenstorm or "Iconoclastic Fury" in 1566 in the Netherlands. On 19 August 1566, this wave of mob destruction reached Ghent, where Marcus van Vaernewijck chronicled the events. He wrote of the Ghent Altarpiece being "taken to pieces and lifted, panel by panel, into the tower to preserve it from the rioters". Antwerp saw very thorough destruction in its churches in 1566, followed by more losses in the Spanish Sack of Antwerp in 1576, and a further period of official iconoclasm in 1581, which now included city and guild buildings, when Calvinists controlled the city council. Many thousands of religious objects and artefacts were