Chait and Roderick MacKinnon Science 280(5360), 69-77 (1998) © American Association for the Advancement of Science Online version Description: The structure of the potassium channel is determined by X-ray crystallography. Access to the structure provided answers to central questions in biology, regarding the movement of ions across the cell membrane. In particular, the structure revealed the mechanism with by which these channels move potassium ions both quickly and selectively, reliably preventing similarly sized sodium ions from passing through. Importance Breakthrough, Influence Analytical chemistry Statistics for Experimenters: An Introduction to Design, Data Analysis, and Model Building George E.P. Box, J. Stuart Hunter & William G. Hunter John Wiley and Sons, Inc., 1st Edition 1978, 2nd Edition 2005 () Importance: Although almost devoid of classical chemistry, this is the definitive text for any experimentalist. This is particularly true for any chemist measuring or studying the properties or effects of chemical compounds, mixtures or other substances. Description: Starting with examples comparing two sets of experimental data, this text explains variance and the calculation of standard deviations, degrees of freedom, the null hypothesis and the "Student's" t-Test by William J. Gosset. Further chapters discuss the importance of randomization and the analysis of variance (ANOVA) using F distributions before delving into the use of statistically designed experiments including block and factorial designs. The book finishes with least squares regression analysis along with response surface and mechanistic modeling. Though chemical examples were few, it should be mentioned that co-author William G. Hunter, George Box's protege, had a Bachelor's and a master's degree in Chemical Engineering with the book written in such a manner that its concepts would easily apply to chemical investigations. Polymer chemistry Principles of Polymer Chemistry Flory, Paul J.(1953) Cornell University Press. 1953, . Importance: First major text on polymer chemistry; presents both organic and physical chemistry aspects. Written by a chemist who made major contributions to the physical chemistry of polymers, for which he won the Nobel prize in 1974. Description: Discusses structure and stereochemistry of synthetic polymers, polymerization kinetics, behaviour of polymers in solution, chain dimensions. Environmental chemistry Aquatic Chemistry, Chemical Equilibria and Rates in Natural Waters Stumm, Werner and James J. Morgan. John Wiley and Sons, Inc., 1st Edition 1970, 3rd Edition 1996, . Description. This book covers the full spectrum of the discipline including acid/base equilibria, carbonate chemistry, mass transfer, complexation, sorption phenomenon, oxidation/reduction, colloid chemistry, and flocculation/coagulation. The authors