the literature that exercising sore muscles appears to be the best way to reduce or eliminate the soreness, but this has not yet been systematically investigated. In 1990, Ibuprofen was found not an appropriate treatment for delayed onset muscle soreness and damage. In 2003, Ibuprofen had been shown to decrease soreness, but not counteract the reduction in muscular performance caused by delayed onset muscle soreness. In 2005, it was found that physical activity conducted before eccentric exercise, with or without ibuprofen, helps to prevent delayed-onset muscle soreness. References Exercise physiology