In the three-part episode "The Spider-Slayers", Spider-Man encounters Kaine before he and Scarlet Spider stumble onto the other Spider-Slayers. As Doctor Octopus escapes, Zola reawakens and commands the Delta-Nine Synthezoids to attack the Web Warriors, but they eventually defeat them and free the Synthezoids from Zola's control. The Delta-Nine Synthezoids are taken to the Triskelion, but Kaine returns in a mutated, misshapen form to absorb the Delta-Nine Synthezoids and become the "Ultimate Spider-Slayer". Despite this, he is defeated by Agent Venom. The Spider-Slayers appear in Spider-Man (2017). These versions resemble spiders and come in human-sized, mecha-sized, and miniature variants. The original Spider-Slayers were created by Spencer Smythe, though Oscorp stole his schematics and created their own versions. Video games The Spider-Slayers appears in Spider-Man (1995). In the SNES version, the Mark X and XIV Spider-Slayers appear as bosses, the Mark XVI and Mark XVII models appear as regular enemies, and the Mark XV is featured only in Spectacular mode. Additionally, the Mark X, XIV, XVI, and XVII Spider-Slayers return as enemies in the final level. The Mark X model also appears in a secret room in the sewers in Spectacular mode. In the Sega Genesis version, the Mark XV Spider-Slayer appears in the "Deconstruction Zone" level while the Mark X model is the boss of the "Mean Streets of the City" level. The Mark X and IX Spider-Slayers appear in The Amazing Spider-Man: Lethal Foes. The Spider-Slayers appear in The Amazing Spider-Man 3: Invasion of the Spider-Slayers. The Spider-Slayers appear in Spider-Man (2002). These versions are human-sized mechanical spiders previously known as "Hnter-Killers" created by Oscorp to hunt down Spider-Man. The Ultimate Marvel incarnation of the Spider-Slayers appear in Spider-Man: Shattered Dimensions. These versions are large androids armed with flamethrowers that were created by S.H.I.E.L.D. as a counter-measure to symbiotes. The Spider-Slayers appear in The Amazing Spider-Man (2012). These versions are called S-Bots and were created by Oscorp under the supervision of CEO Alistair Smythe as a countermeasure for the company's cross-species experiments. They consist of Sentries (which come in Medical, Combat, and Advanced Combat variants), Seekers (used to track down cross-species), and Hunters (arachnid-like flying robots called in by the Seekers to eliminate cross-species once they are found). There are also three special robots created specifically for citywide threats: S-01, a larger version of the Hunter that cannot fly, but can shoot lasers and homing missiles; S-02, a giant