bitter, due in part to their poncirin content. Most people consider them inedible fresh, but they can be made into marmalade. When dried and powdered, they can be used as a condiment. Medicine Traditional medicine The fruits of the trifoliate orange are widely used in medical traditions of East Asia as a treatment for allergic inflammation. Taxonomy The trifoliate orange was historically considered a member of the genus Citrus until Walter Swingle moved it to its own novel genus, Poncirus, based on its deciduous trifoliate leaves differing from other Citrus, as part of a larger reclassification that split the historical Citrus into seven genera. However, David Mabberley and Dianxiang Zhang reunited all of Swingle's novel genera back into Citrus. Early phylogenetic analysis of trifoliate orange plastids nested Poncirus within the citrus, consistent with a single genus, but the sequencing of the nuclear genome by Wu, et al. showed its genome to be most divergent, different enough to justify retention of Poncirus as a separate genus. To explain the conflict between the plastid and nuclear genomic analysis, it was speculated that the trifoliate orange is likely either the progeny of an ancient hybridization between a core citrus and an unidentified more distant relative, or at some time in its history it acquired an introgressed cpDNA genome from another species. Ollitrault, Curk and Krueger indicate that the majority of data are consistent with the enlarged Citrus that includes the trifoliate orange, though they recognize that many botanists still follow Swingle. A second species of trifoliate orange native to Yunnan (China) has been reported and named Poncirus polyandra. Were Poncirus to be subsumed into Citrus, where C. polyandra is unavailable, the name Citrus polytrifolia has been suggested. Zhang and Mabberley concluded this Yunnan cultivar is likely a hybrid between the trifoliate orange and another Citrus, but recent genomic analysis of P. polyandra showed low levels of heterozygosity, the opposite of what one would expect for a hybrid. This analysis dated its divergence from P. trifoliata about 2.82 million years ago. The trifoliate orange does not naturally interbreed with core Citrus taxa due to different flowering times, but hybrids have been produced artificially between the trifoliate orange and other citrus. In the Swingle system, where the trifoliate orange is placed in Poncirus, a hybrid genus name has been coined for these intra-generic crosses, "× Citroncirus". The most notable of these are the citrange, a