the event Spider-Man ever went rogue, the Spider-Slayers are deployed by Nick Fury to Peter Parker's residence when clones of Spider-Man begin running rampant, with the Slayers' objective being to arrest Peter Parker. The Slayers encounter the Fantastic Four and Carnage which reverts to Gwen Stacy after the Spider-Slayers take her down. The Spider-Slayers later kill a disfigured clone and imprison another unstable clone in S.H.I.E.L.D. MC2 While trying to apprehend a dimension-hopping supervillain in the MC2 reality, Spider-Girl is accidentally sent into Earth-616's past, where she encounters the first Spider-Slayer. Mistaking her for its quarry, the Spider-Slayer attacks Spider-Girl who manages to evade the machine due to being distracted by how different "Spider-Man" looks. Spider-Girl later returns to her own universe and time, while Spider-Man defeats the Spider-Slayer in the same way he did in the original story. House of M In the House of M reality, J. Jonah Jameson (fearing Peter Parker would take revenge due to outing as Spider-Man) has Alistair Smythe construct a Spider-Slayer as protection. When Peter's family breaks into Jonah's home looking for Peter's journal (given by the Green Goblin) Jonah, using the Spider-Slayer, attacks. Hitting Gwen Stacy just as Peter arrives, Jonah's Spider-Slayer is ripped to shreds by the hero. What If After May Parker and John Jameson are killed in a space shuttle crash caused by the Chameleon, J. Jonah Jameson adopts Peter Parker, and blames the deaths of their loved ones on Spider-Man. Obsessed with taking Spider-Man down, Jameson commissions the creation of the Spider-Slayer and the Scorpion formula, the latter of which is ingested by Flash Thompson. The serum warps Flash's mind and causes Flash to go on a rampage, which ends when subdued by Spider-Man (who reveals being Peter Parker to Jameson) and the Spider-Slayer, controlled by Jameson. Jameson realizes how irrational his hatred of Spider-Man is, and decides to help his adopted son fight crime using the Spider-Slayer. In other media Television The Mark I Spider-Slayer appears in the Spider-Man (1967) episode "Captured by J. Jonah Jameson". This version was built by Henry Smythe and is equipped with two metallic tentacle-like arms. The Spider-Slayers appear in Spider-Man: The Animated Series. In its self-titled episode, Spencer Smythe, with help from Norman Osborn, builds a Spider-Slayer called the "Black Widow" to hunt down Spider-Man. However, it is destroyed after a battle with the hero at Spencer's lab, resulting in its